Search Results - "BUCKHAULTS, Phillip"

Early-onset colorectal cancer: initial clues and current views by Hofseth, Lorne J., Hebert, James R., Chanda, Anindya, Chen, Hexin, Love, Bryan L., Pena, Maria M., Murphy, E. Angela, Sajish, Mathew, Sheth, Amit, Buckhaults, Phillip J., Berger, Franklin G.

“…Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in patients <50 years old) has increased at an alarming rate. Although…”
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Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer by Saatci, Ozge, Kaymak, Aysegul, Raza, Umar, Ersan, Pelin G., Akbulut, Ozge, Banister, Carolyn E., Sikirzhytski, Vitali, Tokat, Unal Metin, Aykut, Gamze, Ansari, Suhail A., Dogan, Hayriye Tatli, Dogan, Mehmet, Jandaghi, Pouria, Isik, Aynur, Gundogdu, Fatma, Kosemehmetoglu, Kemal, Dizdar, Omer, Aksoy, Sercan, Akyol, Aytekin, Uner, Aysegul, Buckhaults, Phillip J., Riazalhosseini, Yasser, Sahin, Ozgur

“…Chemoresistance is a major obstacle in triple negative breast cancer (TNBC), the most aggressive breast cancer subtype. Here we identify hypoxia-induced ECM…”
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Novel somatic mutations to PI3K pathway genes in metastatic melanoma by Shull, Austin Y, Latham-Schwark, Alicia, Ramasamy, Poornema, Leskoske, Kristin, Oroian, Dora, Birtwistle, Marc R, Buckhaults, Phillip J

“…BRAF(V600) inhibitors have offered a new gateway for better treatment of metastatic melanoma. However, the overall efficacy of BRAF(V600) inhibitors has been…”
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Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy by Liu, Changlong, Banister, Carolyn E, Buckhaults, Phillip J

“…TP53 mutations are common in most human cancers, but few therapeutic options for TP53-mutant tumors exist. To identify potential therapeutic options for cancer…”
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Identification and characterization of HPV-independent cervical cancers by Banister, Carolyn E, Liu, Changlong, Pirisi, Lucia, Creek, Kim E, Buckhaults, Phillip J

“…Human papillomavirus (HPV) initiates cervical cancer, and continuous expression of HPV oncogenes E6 and E7 is thought to be necessary to maintain malignant…”
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Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis by Ibrahim, Mohammed L., Klement, John D., Lu, Chunwan, Redd, Priscilla S., Xiao, Wei, Yang, Dafeng, Browning, Darren D., Savage, Natasha M., Buckhaults, Phillip J., Morse, Herbert C., Liu, Kebin

“…IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism…”
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PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids by Liu, Changlong, Banister, Carolyn E., Weige, Charles C., Altomare, Diego, Richardson, Joseph H., Contreras, Carlo M., Buckhaults, Phillip J.

“…PRDM1 is a tumor suppressor that plays an important role in B and T cell lymphomas. Our previous studies demonstrated that PRDM1β is a p53-response gene in…”
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Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer by Shelar, Sandeep, Shim, Eun-Hee, Brinkley, Garrett J, Kundu, Anirban, Carobbio, Francesca, Poston, Tyler, Tan, Jubilee, Parekh, Vishwas, Benson, Daniel, Crossman, David K, Buckhaults, Phillip J, Rakheja, Dinesh, Kirkman, Richard, Sato, Yusuke, Ogawa, Seishi, Dutta, Shilpa, Velu, Sadanandan E, Emberley, Ethan, Pan, Alison, Chen, Jason, Huang, Tony, Absher, Devin, Becker, Anja, Kunick, Conrad, Sudarshan, Sunil

“…Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the…”
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Genomic Landscapes of Human Breast and Colorectal Cancers by Wood, Laura D, Parsons, D. Williams, Jones, Siân, Lin, Jimmy, Sjöblom, Tobias, Leary, Rebecca J, Shen, Dong, Boca, Simina M, Barber, Thomas, Ptak, Janine, Silliman, Natalie, Szabo, Steve, Dezso, Zoltan, Ustyanksky, Vadim, Nikolskaya, Tatiana, Nikolsky, Yuri, Karchin, Rachel, Wilson, Paul A, Kaminker, Joshua S, Zhang, Zemin, Croshaw, Randal, Willis, Joseph, Dawson, Dawn, Shipitsin, Michail, Willson, James K.V, Sukumar, Saraswati, Polyak, Kornelia, Park, Ben Ho, Pethiyagoda, Charit L, Pant, P.V. Krishna, Ballinger, Dennis G, Sparks, Andrew B, Hartigan, James, Smith, Douglas R, Suh, Erick, Papadopoulos, Nickolas, Buckhaults, Phillip, Markowitz, Sanford D, Parmigiani, Giovanni, Kinzler, Kenneth W, Velculescu, Victor E, Vogelstein, Bert

“…Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during…”
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Consensus Coding Sequences of Human Breast and Colorectal Cancers by Sjöblom, Tobias, Jones, Siân, Wood, Laura D, Parsons, D. Williams, Lin, Jimmy, Barber, Thomas D, Mandelker, Diana, Leary, Rebecca J, Ptak, Janine, Silliman, Natalie, Szabo, Steve, Buckhaults, Phillip, Farrell, Christopher, Meeh, Paul, Markowitz, Sanford D, Willis, Joseph, Dawson, Dawn, Willson, James K.V, Gazdar, Adi F, Hartigan, James, Wu, Leo, Liu, Changsheng, Parmigiani, Giovanni, Park, Ben Ho, Bachman, Kurtis E, Papadopoulos, Nickolas, Vogelstein, Bert, Kinzler, Kenneth W, Velculescu, Victor E

“…The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic…”
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Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients by Shull, Austin Y, Clendenning, Megan L, Ghoshal-Gupta, Sampa, Farrell, Christopher L, Vangapandu, Hima V, Dudas, Larry, Wilkerson, Brent J, Buckhaults, Phillip J

“…The Cub and Sushi Multiple Domains 1 (CSMD1) gene, located on the short arm of chromosome 8, codes for a type I transmembrane protein whose function is…”
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The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice by Zhang, Qi, Chumanevich, Alexander A., Nguyen, Ivy, Chumanevich, Anastasiya A., Sartawi, Nora, Hogan, Jake, Khazan, Minou, Harris, Quinn, Massey, Bryson, Chatzistamou, Ioulia, Buckhaults, Phillip J., Banister, Carolyn E., Wirth, Michael, Hebert, James R., Murphy, E. Angela, Hofseth, Lorne J.

“…The incidence of colorectal cancer (CRC) among young people has been on the rise for the past four decades and its underlying causes are only just starting to…”
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Association of the Actin-Binding Protein Transgelin with Lymph Node Metastasis in Human Colorectal Cancer by Lin, Ying, Buckhaults, Phillip J., Lee, Jeffrey R., Xiong, Hairong, Farrell, Christopher, Podolsky, Robert H., Schade, Robert R., Dynan, William S.

“…Metastatic dissemination of primary tumors is responsible for 90% of colorectal cancer (CRC) deaths. The presence of positive lymph nodes, which separates…”
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Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry by Makena, Monish Ram, Ko, Myungjun, Mekile, Allatah X., Senoo, Nanami, Dang, Donna K., Warrington, John, Buckhaults, Phillip, Talbot, C. Conover, Claypool, Steven M., Rao, Rajini

“…A complex interplay between the extracellular space, cytoplasm and individual organelles modulates Ca2+ signaling to impact all aspects of cell fate and…”
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Publisher Correction: Early-onset colorectal cancer: initial clues and current views by Hofseth, Lorne J., Hebert, James R., Chanda, Anindya, Chen, Hexin, Love, Bryan L., Pena, Maria M., Murphy, E. Angela, Sajish, Mathew, Sheth, Amit, Buckhaults, Phillip J., Berger, Franklin G.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Frequent mutations in the MITF pathway in melanoma by Cronin, Julia C., Wunderlich, John, Loftus, Stacie K., Prickett, Todd D., Wei, Xiaomu, Ridd, Katie, Vemula, Swapna, Burrell, Allison S., Agrawal, Neena S., Lin, Jimmy C., Banister, Carolyn E., Buckhaults, Phillip, Rosenberg, Steven A., Bastian, Boris C., Pavan, William J., Samuels, Yardena

“…Summary Microphthalmia‐associated transcription factor (MITF) is involved in melanocyte cell development, pigmentation and neoplasia. To determine whether MITF…”
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Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers by KOOPMANN, Jens, BUCKHAULTS, Phillip, BREIT, Samuel N, KINZLER, Kenneth W, VOGELSTEIN, Bert, GOGGINS, Michael, BROWN, David A, ZAHURAK, Marianna L, SATO, Norihiro, FUKUSHIMA, Noriyoshi, SOKOLL, Lori J, CHAN, Daniel W, YEO, Charles J, HRUBAN, Ralph H

“…Purpose: Patients with pancreatic ductal adenocarcinoma usually present with advanced-stage disease and a dismal prognosis. One effective strategy likely to…”
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Association of FGD1 polymorphisms with early-onset breast cancer by Beasley, Sarah, Buckhaults, Phillip J, Pedigo, Nancy G, Farrell, Christopher L

“…Recent cancer studies have suggested that the faciogenital dysplasia 1 (FGD1) gene may play a role in the development of tumor cells. Somatic alterations in…”
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Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators by Zawel, Leigh, Le Dai, Jia, Buckhaults, Phillip, Zhou, Shibin, Kinzler, Kenneth W, Vogelstein, Bert, Kern, Scott E

“…Mounting evidence indicates that Smad proteins are required for TGFβ signaling, but the way(s) in which Smad proteins propagate this signal is unclear. We…”
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Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans by Weige, Charles C, Birtwistle, Marc R, Mallick, Himel, Yi, Nengjun, Berrong, Zuzana, Cloessner, Emily, Duff, Keely, Tidwell, Josephine, Clendenning, Megan, Wilkerson, Brent, Farrell, Christopher, Bunz, Fred, Ji, Hao, Shtutman, Michael, Creek, Kim E, Banister, Carolyn E, Buckhaults, Phillip J

“…African Americans are disproportionately affected by early-onset, high-grade malignancies. A fraction of this cancer health disparity can be explained by…”
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