Search Results - "BUCHANAN, Paul J"

CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics by Buchanan, Paul J., McCloskey, Karen D.

“…The importance of ion channels in the hallmarks of many cancers is increasingly recognised. This article reviews current knowledge of the expression of members…”
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Acute radiation impacts contractility of guinea-pig bladder strips affecting mucosal-detrusor interactions by McDonnell, Bronagh M, Buchanan, Paul J, Prise, Kevin M, McCloskey, Karen D

“…Radiation-induced bladder toxicity is associated with radiation therapy for pelvic malignancies, arising from unavoidable irradiation of neighbouring normal…”
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Influenza infection directly alters innate IL-23 and IL-12p70 and subsequent IL-17A and IFN-γ responses to pneumococcus in vitro in human monocytes by Loughran, Sinead T, Power, Patrick A, Maguire, Paula T, McQuaid, Samantha L, Buchanan, Paul J, Jonsdottir, Ingileif, Newman, Robert W, Harvey, Ruth, Johnson, Patricia A

“…Influenza virus is highly contagious and poses substantial public health problems due to its strong association with morbidity and mortality. Approximately…”
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Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo by Scott, Aaron, Weldon, Sinéad, Buchanan, Paul J, Schock, Bettina, Ernst, Robert K, McAuley, Danny F, Tunney, Michael M, Irwin, Chris R, Elborn, J Stuart, Taggart, Clifford C

“…Human cathelicidin LL-37 is a cationic antimicrobial peptide (AMP) which possesses a variety of activities including the ability to neutralise endotoxin. In…”
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Hypoxia induced cancer stem cell enrichment promotes resistance to androgen deprivation therapy in prostate cancer by O'Reilly, Debbie, Johnson, Patricia, Buchanan, Paul J.

“…•Androgen deprivation therapy is directly linked to increased stem cell populations.•Prostate cancer stem cells correlate with poorer patient outcomes.•Hypoxic…”
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Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation by Buchanan, Paul J, Ernst, Robert K, Elborn, J Stuart, Schock, Bettina

“…CF (cystic fibrosis) is a severe autosomal recessive disease most common in Northwest European populations. Underlying mutations in the CFTR (CF transmembrane…”
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Ca V channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics by Buchanan, Paul J, McCloskey, Karen D

“…The importance of ion channels in the hallmarks of many cancers is increasingly recognised. This article reviews current knowledge of the expression of members…”
Get full text

CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer by O'Reilly, Debbie, Downing, Tim, Kouba, Sana, Potier-Cartereau, Marie, McKenna, Declan J., Vandier, Christophe, Buchanan, Paul J.

“…•CaV1.3 is upregulated in prostate cancer during androgen deprivation therapy•Expression of short 170kDa isoform determines CaV1.3 function in PCa•Store…”
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Hypoxic Signaling Is Modulated by Calcium Channel, CaV1.3, in Androgen-Resistant Prostate Cancer by O'Reilly, Debbie, Buchanan, Paul J

“…Androgen deprivation therapy (ADT) remains a key treatment for advance prostate cancer (PCa), but resistance leads to terminal castrate-resistant prostate…”
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Bioelectricity of the Tumor Microenvironment by Buchanan, Paul J, Vandier, Christophe

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Lipoxin A₄-mediated KATP potassium channel activation results in cystic fibrosis airway epithelial repair by Buchanan, Paul J, McNally, Paul, Harvey, Brian J, Urbach, Valerie

“…The main cause of morbidity and mortality in cystic fibrosis (CF) is progressive lung destruction as a result of persistent bacterial infection and…”
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Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis by RINGHOLZ, Fiona C, BUCHANAN, Paul J, CLARKE, Donna T, MILLAR, Roisin G, MCDERMOTT, Michael, LINNANE, Barry, HARVEY, Brian J, MCNALLY, Paul, URBACH, Valerie

“…Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance, persistent bacterial infection and neutrophilic inflammation…”
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Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer by Eustace, Alex J., Lee, Min Jie, Colley, Grace, Roban, Jack, Downing, Tim, Buchanan, Paul J.

“…Triple-negative breast cancer (TNBC) is characterized as an aggressive form of breast cancer (BC) associated with poor patient outcomes. For the majority of…”
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Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells by Kelly, Catriona, Canning, Paul, Buchanan, Paul J, Williams, Mark T, Brown, Vanessa, Gruenert, Dieter C, Elborn, J Stuart, Ennis, Madeleine, Schock, Bettina C

“…The innate immune response to bacterial infection is mediated through Toll-like receptors (TLRs), which trigger tightly regulated signaling cascades through…”
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Ca sub(V) channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics by Buchanan, Paul J, McCloskey, Karen D

“…The importance of ion channels in the hallmarks of many cancers is increasingly recognised. This article reviews current knowledge of the expression of members…”
Get full text

Influenza infection directly alters innate IL-23 and IL-12p70 and subsequent IL-17A and IFN-[gamma] responses to pneumococcus in vitro in human monocytes by Loughran, Sinead T, Power, Patrick A, Maguire, Paula T, McQuaid, Samantha L, Buchanan, Paul J, Jonsdottir, Ingileif, Newman, Robert W, Harvey, Ruth, Johnson, Patricia A

“…It is well accepted that influenza A virus predisposes individuals to often more severe superinfections with Streptococcus pneumonia. However, the mechanisms…”
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Reduced 15-lipoxygenase 2 and lipoxin A 4 /leukotriene B 4 ratio in children with cystic fibrosis by Ringholz, Fiona C., Buchanan, Paul J., Clarke, Donna T., Millar, Roisin G., McDermott, Michael, Linnane, Barry, Harvey, Brian J., McNally, Paul, Urbach, Valerie

“…Airway disease in cystic fibrosis (CF) is characterised by impaired mucociliary clearance, persistent bacterial infection and neutrophilic inflammation…”
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Information structures in notated music: Statistical explorations of composers' performance marks in solo piano scores by Buchanan, J Paul

“…Written notation has a long history in many musical traditions and has been particularly important in the composition and performance of Western art music…”
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Ca^sub V^ channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics by Buchanan, Paul J, Mccloskey, Karen D

“…The importance of ion channels in the hallmarks of many cancers is increasingly recognised. This article reviews current knowledge of the expression of members…”
Get full text