Search Results - "BUARD, Jérome"

Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21 by Grunau, Christoph, Buard, Jérome, Brun, Marie-Elisabeth, De Sario, Albertina

“…Euchromatin and heterochromatin are functional compartments of the genome. However, little is known about the structure and the precise location of the…”
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Distinct histone modifications define initiation and repair of meiotic recombination in the mouse by Buard, Jérôme, Barthès, Pauline, Grey, Corinne, de Massy, Bernard

“…Little is known about the factors determining the location and activity of the rapidly evolving meiotic crossover hotspots that shape genome diversity. Here,…”
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Diversity of Prdm9 zinc finger array in wild mice unravels new facets of the evolutionary turnover of this coding minisatellite by Buard, Jérôme, Rivals, Eric, Dunoyer de Segonzac, Denis, Garres, Charlotte, Caminade, Pierre, de Massy, Bernard, Boursot, Pierre

“…In humans and mice, meiotic recombination events cluster into narrow hotspots whose genomic positions are defined by the PRDM9 protein via its DNA binding…”
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In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites by Grey, Corinne, Clément, Julie A J, Buard, Jérôme, Leblanc, Benjamin, Gut, Ivo, Gut, Marta, Duret, Laurent, de Massy, Bernard

“…In mouse and human meiosis, DNA double-strand breaks (DSBs) initiate homologous recombination and occur at specific sites called hotspots. The localization of…”
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Playing hide and seek with mammalian meiotic crossover hotspots by Buard, Jérôme, de Massy, Bernard

“…Crossovers (COs) are essential for meiosis and contribute to genome diversity by promoting the reassociation of alleles, and thus improve the efficiency of…”
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Private selective sweeps identified from next-generation pool-sequencing reveal convergent pathways under selection in two inbred Schistosoma mansoni strains by Clément, Julie A J, Toulza, Eve, Gautier, Mathieu, Parrinello, Hugues, Roquis, David, Boissier, Jérôme, Rognon, Anne, Moné, Hélène, Mouahid, Gabriel, Buard, Jérôme, Mitta, Guillaume, Grunau, Christoph

“…The trematode flatworms of the genus Schistosoma, the causative agents of schistosomiasis, are among the most prevalent parasites in humans, affecting more…”
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Epigenetic origin of adaptive phenotypic variants in the human blood fluke Schistosoma mansoni by Fneich, Sara, Théron, André, Cosseau, Céline, Rognon, Anne, Aliaga, Benoit, Buard, Jérôme, Duval, David, Arancibia, Nathalie, Boissier, Jérôme, Roquis, David, Mitta, Guillaume, Grunau, Christoph

“…Adaptive evolution is not possible without the generation of phenotypic variants. The origin of these variations has been a central topic in evolutionary…”
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Male cell microchimerism in normal and diseased female livers from fetal life to adulthood by GUETTIER, Catherine, SEBAGH, Mylène, BUARD, Jérome, FENEUX, Danielle, ORTIN-SERRANO, Monique, GIGOU, Michele, TRICOTTET, Viviane, REYNES, Michel, SAMUEL, Didier, FERAY, Cyrille

“…Male microchimerism is frequent in the adult female liver and is attributed to fetal cells originating from previous male offspring. It has never been studied…”
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Recombination across the centromere of disjoined and non-disjoined chromosome 21 by Laurent, Anne-Marie, Li, Meizhang, Sherman, Stephanie, Roizès, Gérard, Buard, Jérôme

“…Meiotic recombination is generally suppressed across the centromere of eukaryotic chromosomes. In human, megabase-long satellite sequences and contiguous…”
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Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes by STEAD, John D. H, BUARD, Jérome, TODD, John A, JEFFREYS, Alec J

“…The insulin minisatellite or variable number of tandem repeats locus (INS VNTR) is the best candidate for the type 1 diabetes mellitus (T1DM) susceptibility…”
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A Fast and Specific Alignment Method for Minisatellite Maps by Bérard, Sèverine, Nicolas, François, Buard, Jérôme, Gascuel, Olivier, Rivals, Eric

“…Background Variable minisatellites count among the most polymorphic markers of eukaryotic and prokaryotic genomes. This variability can affect gene coding…”
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What determines the localisation of spots of meiotic recombination? by Baudat, Frédéric, Buard, Jérôme, Grey, Corinne, de Massy, Bernard

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Somatic versus Germline Mutation Processes at Minisatellite CEB1 (D2S90) in Humans and Transgenic Mice by Buard, Jérôme, Collick, Andrew, Brown, Jane, Jeffreys, Alec J.

“…The most variable human minisatellites show extreme germline instability dominated by complex intra-allelic rearrangements plus a lower frequency of…”
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Prdm9, a key control of mammalian recombination hotspots by Baudat, Frédéric, Buard, Jérôme, Grey, Corinne, de Massy, Bernard

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Evolutionary Fate of an Unstable Human Minisatellite Deduced from Sperm-Mutation Spectra of Individual Alleles by Buard, Jérôme, Brenner, Charles, Jeffreys, Alec J.

“…Although mutation processes at some human minisatellites have been extensively characterized, the evolutionary fate of these unstable loci is unknown…”
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Further evidence for elevated human minisatellite mutation rate in Belarus eight years after the Chernobyl accident by Dubrova, Y E, Nesterov, V N, Krouchinsky, N G, Ostapenko, V A, Vergnaud, G, Giraudeau, F, Buard, J, Jeffreys, A J

“…Analysis of germline mutation rate at human minisatellites among children born in areas of the Mogilev district of Belarus heavily polluted after the Chernobyl…”
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Spontaneous and induced minisatellite instability by Jeffreys, A J, Bois, P, Buard, J, Collick, A, Dubrova, Y, Hollies, C R, May, C A, Murray, J, Neil, D L, Neumann, R, Stead, J D, Tamaki, K, Yardley, J

“…Minisatellites provide not only the basis for DNA fingerprinting and DNA profiling but also extremely informative systems for analysing processes of tandem…”
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Private Selective Sweeps Identified from Next-Generation Pool-Sequencing Reveal Convergent Pathways under Selection in Two Inbred Schistosoma mansoni Strains: e2591 by Clément, Julie AJ, Toulza, Eve, Gautier, Mathieu, Parrinello, Hugues, Roquis, David, Boissier, Jérôme, Rognon, Anne, Moné, Hélène, Mouahid, Gabriel, Buard, Jérôme, Mitta, Guillaume, Grunau, Christoph

“…Background The trematode flatworms of the genus Schistosoma, the causative agents of schistosomiasis, are among the most prevalent parasites in humans,…”
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Instability of the human minisatellite CEB1 in rad27Δ and dna2-1 replication-deficient yeast cells by Lopes, Judith, Debrauwère, Hélène, Buard, Jérôme, Nicolas, Alain

“…Convergent studies in human and yeast model systems have shown that some minisatellite loci are relatively stable in somatic cells but not in the germline, and…”
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Complex recombination events at the hypermutable minisatellite CEB1 (D2S90) by Buard, J., Vergnaud, G.

“…Some minisatellite structures are the site of high rates of DNA recombination in non‐pathological situations, with an excess of motif insertion events and a…”
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