Search Results - "BRULARD, Céline"

Chromosome Instability Accounts for Reverse Metastatic Outcomes of Pediatric and Adult Synovial Sarcomas by LAGARDE, Pauline, PRZYBYL, Joanna, NEUVILLE, Agnès, COINDRE, Jean-Michel, ITALIANO, Antoine, ORBACH, Daniel, DEBIEC-RYCHTER, Maria, CHIBON, Frédéric, BRULARD, Céline, PEROT, Gaelle, PIERRON, Gaelle, DELATTRE, Olivier, SCIOT, Raf, WOZNIAK, Agnieszka, SCHÖFFSKI, Patrick, TERRIER, Philippe

“…Synovial sarcoma (SS) occurs in both children and adults, although metastatic events are much more common in adults. Whereas the importance of the t(X;18)…”
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Post-Translational Variants of Major Proteins in Amyotrophic Lateral Sclerosis Provide New Insights into the Pathophysiology of the Disease by Bedja-Iacona, Léa, Richard, Elodie, Marouillat, Sylviane, Brulard, Céline, Alouane, Tarek, Beltran, Stéphane, Andres, Christian R, Blasco, Hélène, Corcia, Philippe, Veyrat-Durebex, Charlotte, Vourc'h, Patrick

“…Post-translational modifications (PTMs) affecting proteins during or after their synthesis play a crucial role in their localization and function. The…”
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Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors by LAGARDE, Pauline, PEROT, Gaëlle, AURIAS, Alain, COINDRE, Jean-Michel, DEBIEC-RYCHTER, Maria, CHIBON, Frédéric, KAUFFMANN, Audrey, BRULARD, Céline, DAPREMONT, Valérie, HOSTEIN, Isabelle, NEUVILLE, Agnes, WOZNIAK, Agnieszka, SCIOT, Raf, SCHÖFFSKI, Patrick

“…The importance of KIT and PDGFRA mutations in the oncogenesis of gastrointestinal stromal tumors (GIST) is well established, but the genetic basis of GIST…”
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Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1 by Haouari, Shanez, Andres, Christian Robert, Lanznaster, Debora, Marouillat, Sylviane, Brulard, Céline, Dangoumau, Audrey, Ung, Devina, Veyrat-Durebex, Charlotte, Laumonnier, Frédéric, Blasco, Hélène, Couratier, Philippe, Corcia, Philippe, Vourc'h, Patrick

“…The ubiquitin pathway, one of the main actors regulating cell signaling processes and cellular protein homeostasis, is directly involved in the pathophysiology…”
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Dysregulations of Expression of Genes of the Ubiquitin/SUMO Pathways in an In Vitro Model of Amyotrophic Lateral Sclerosis Combining Oxidative Stress and SOD1 Gene Mutation by Dangoumau, Audrey, Marouillat, Sylviane, Coelho, Roxane, Wurmser, François, Brulard, Céline, Haouari, Shanez, Laumonnier, Frédéric, Corcia, Philippe, Andres, Christian R, Blasco, Hélène, Vourc'h, Patrick

“…Protein aggregates in affected motor neurons are a hallmark of amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to their formation…”
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Recurrent TRIO Fusion in Nontranslocation-Related Sarcomas by Delespaul, Lucile, Lesluyes, Tom, Pérot, Gaëlle, Brulard, Céline, Lartigue, Lydia, Baud, Jessica, Lagarde, Pauline, Le Guellec, Sophie, Neuville, Agnès, Terrier, Philippe, Vince-Ranchère, Dominique, Schmidt, Susanne, Debant, Anne, Coindre, Jean-Michel, Chibon, Frédéric

“…Despite various differences, nontranslocation-related sarcomas (e.g., comprising undifferentiated pleomorphic sarcoma, leiomyosarcoma, myxofibrosarcoma) are…”
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A novel mutation in the transmembrane 6 domain of GABBR2 leads to a Rett‐like phenotype by Vuillaume, Marie‐Laure, Jeanne, Médéric, Xue, Li, Blesson, Sophie, Denommé‐Pichon, Anne‐Sophie, Alirol, Servane, Brulard, Céline, Colin, Estelle, Isidor, Bertrand, Gilbert‐Dussardier, Brigitte, Odent, Sylvie, Parent, Philippe, Donnart, Audrey, Redon, Richard, Bézieau, Stéphane, Rondard, Philippe, Laumonnier, Frédéric, Toutain, Annick

“…We read with great interest the recent article published by Yooet al1reporting 4 additional Rett-like (RTT) patients with therecurring…”
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A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression by Liu, Jing, Ottaviani, Daniela, Sefta, Meriem, Desbrousses, Céline, Chapeaublanc, Elodie, Aschero, Rosario, Sirab, Nanor, Lubieniecki, Fabiana, Lamas, Gabriela, Tonon, Laurie, Dehainault, Catherine, Hua, Clément, Fréneaux, Paul, Reichman, Sacha, Karboul, Narjesse, Biton, Anne, Mirabal-Ortega, Liliana, Larcher, Magalie, Brulard, Céline, Arrufat, Sandrine, Nicolas, André, Elarouci, Nabila, Popova, Tatiana, Némati, Fariba, Decaudin, Didier, Gentien, David, Baulande, Sylvain, Mariani, Odette, Dufour, Florent, Guibert, Sylvain, Vallot, Céline, Rouic, Livia Lumbroso-Le, Matet, Alexandre, Desjardins, Laurence, Pascual-Pasto, Guillem, Suñol, Mariona, Catala-Mora, Jaume, Llano, Genoveva Correa, Couturier, Jérôme, Barillot, Emmanuel, Schaiquevich, Paula, Gauthier-Villars, Marion, Stoppa-Lyonnet, Dominique, Golmard, Lisa, Houdayer, Claude, Brisse, Hervé, Bernard-Pierrot, Isabelle, Letouzé, Eric, Viari, Alain, Saule, Simon, Sastre-Garau, Xavier, Doz, François, Carcaboso, Angel M., Cassoux, Nathalie, Pouponnot, Celio, Goureau, Olivier, Chantada, Guillermo, de Reyniès, Aurélien, Aerts, Isabelle, Radvanyi, François

“…Retinoblastoma is the most frequent intraocular malignancy in children, originating from a maturing cone precursor in the developing retina. Little is known on…”
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Genes containing hexanucleotide repeats resembling C9ORF72 and expressed in the central nervous system are frequent in the human genome by Vourc’h, Patrick, Wurmser, François, Brulard, Céline, Mouzat, Kevin, Kassem, Sandra, Dangoumau, Audrey, Laumonnier, Frédéric, Blasco, Hélène, Corcia, Philippe, Andres, Christian R.

“…More than 40 human diseases, mainly diseases affecting the central nervous system, are caused by the expansion of unstable nucleotide repeats. Repeats of…”
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RNA sequencing validation of the Complexity INdex in SARComas prognostic signature by Lesluyes, Tom, Pérot, Gaëlle, Largeau, Marine Roxane, Brulard, Céline, Lagarde, Pauline, Dapremont, Valérie, Lucchesi, Carlo, Neuville, Agnès, Terrier, Philippe, Vince-Ranchère, Dominique, Mendez-Lago, Maria, Gut, Marta, Gut, Ivo, Coindre, Jean-Michel, Chibon, Frédéric

“…Abstract Background Prognosis of metastatic outcome in soft tissue sarcomas is an important clinical challenge since these tumours can be very aggressive (up…”
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Robust gene expression signature is not merely a significant P value by Brulard, Céline, Chibon, Frédéric

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Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions by Croce, Sabrina, Ribeiro, Agnes, Brulard, Celine, Noel, Jean-Christophe, Amant, Frederic, Stoeckle, Eberhard, Devouassoux-Shisheborah, Mojgan, Floquet, Anne, Arnould, Laurent, Guyon, Frederic, Mishellany, Florence, Garbay, Delphine, Cuppens, Tine, Zikan, Michal, Leroux, Agnès, Frouin, Eric, Duvillard, Pierre, Terrier, Philippe, Farre, Isabelle, Valo, Isabelle, MacGrogan, Gaetan M, Chibon, Frederic

“…The diagnosis and management of uterine smooth muscle tumors with uncertain malignant potential (STUMP) is often challenging, and genomic data on these lesions…”
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Genomic index predicts clinical outcome of intermediate-risk gastrointestinal stromal tumours, providing a new inclusion criterion for imatinib adjuvant therapy by Lartigue, Lydia, Neuville, Agnès, Lagarde, Pauline, Brulard, Céline, Rutkowski, Piotr, Tos, Paolo Dei, Wardelmann, Eva, Debiec-Rychter, Maria, Italiano, Antoine, Coindre, Jean-Michel, Chibon, Frédéric

“…Abstract Purpose Imatinib mesylate is the front-line targeted therapy for gastrointestinal stromal tumours (GISTs). Patient’s eligibility to adjuvant imatinib…”
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Mutation in the RRM2 domain of TDP-43 in Amyotrophic Lateral Sclerosis with rapid progression associated with ubiquitin positive aggregates in cultured motor neurons by Maurel, Cindy, Madji-Hounoum, Blandine, Thepault, Rose-Anne, Marouillat, Sylviane, Brulard, Céline, Danel-Brunaud, Véronique, Camdessanche, Jean-Philippe, Blasco, Helene, Corcia, Philippe, Andres, Christian R, Vourc'h, Patrick

“…Mutations in the TAR-DNA Binding Protein-43 (TDP-43) encoding the TARDBP gene are present in amyotrophic lateral sclerosis (ALS). TDP-43 is the major component…”
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Genetic Profiling Identifies Two Classes of Soft-Tissue Leiomyosarcomas with Distinct Clinical Characteristics by ITALIANO, Antoine, LAGARDE, Pauline, PIPERNONEUMANN, Sophie, CHEVREAU, Christine, BLAY, Jean-Yves, DELCAMBRE, Corinne, ISAMBERT, Nicolas, PENEL, Nicolas, BAY, Jacques-Olivier, BONVALOT, Sylvie, LE CESNE, Axel, COINDRE, Jean-Michel, BRULARD, Céline, CHIBON, Frédéric, TERRIER, Philippe, LAË, Marick, MARQUES, Bernard, RANCHERE-VINCE, Dominique, MICHELS, Jean-Jacques, TRASSARD, Martine, CIOFFI, Angela

“…Data about the prognostic factors of soft-tissue leiomyosarcomas and their correlation with molecular profile are limited. From 1990 to 2010, 586 adult…”
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Deep sequencing is an appropriate tool for the selection of unique Hepatitis C virus (HCV) variants after single genomic amplification by Guinoiseau, Thibault, Moreau, Alain, Hohnadel, Guillaume, Ngo-Giang-Huong, Nicole, Brulard, Celine, Vourc'h, Patrick, Goudeau, Alain, Gaudy-Graffin, Catherine

“…Hepatitis C virus (HCV) evolves rapidly in a single host and circulates as a quasispecies wich is a complex mixture of genetically distinct virus's but closely…”
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RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas by Mauduit, Olivier, Brulard, Céline, Lesluyes, Tom, Delcroix, Vanessa, Pérot, Gaëlle, Choublier, Nina, Michaud, Mickael, Baud, Jessica, Lagarde, Pauline, Aurias, Alain, Coindre, Jean-Michel, Lartigue, Lydia, Blay, Jean-Yves, Chibon, Frédéric

“…Half of soft-tissue sarcomas are tumors with complex genomics, which display no specific genetic alterations and respond poorly to treatment. It is therefore…”
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Recurrent \textitTRIO Fusion in Nontranslocation\textendashRelated Sarcomas by Delespaul, Lucile, Lesluyes, Tom, Pérot, Gaëlle, Brulard, Céline, Lartigue, Lydia, Baud, Jessica, Lagarde, Pauline, Le Guellec, Sophie, Neuville, Agnès, Terrier, Philippe, Vince-Ranchère, Dominique, Schmidt, Susanne, Debant, Anne, Coindre, Jean-Michel, Chibon, Frédéric

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Abstract 3829: Genomic index is a strong predictor of metastatic outcome in intermediate gastrointestinal stromal tumors and an inclusion criteria for imatinib adjuvant therapy by Lartigue, Lydia, Lagarde, Pauline, Brulard, Céline, Neuville, Agnès, Rutkowski, Piotr, Tos, Paolo Dei, Waldermann, Eva, Debiec-Rychter, Maria, Italiano, Antoine, Coindre, Jean-Michel, Chibon, Frédéric

“…Gastrointestinal stroma tumors (GISTs) harboring a cKIT / PDGFRA activating mutation in 90% of cases benefit from the Imatinib mesylate (Glivec®) targeted…”
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Effect of familial clustering in the genetic screening of 235 French ALS families by Corcia, Philippe, Camu, William, Brulard, Celine, Marouillat, Sylviane, Couratier, Philippe, Camdessanché, Jean-Philippe, Cintas, Pascal, Verschueren, Annie, Soriani, Marie-Helene, Desnuelle, Claude, Fleury, Marie-Céline, Guy, Nathalie, Cassereau, Julien, Viader, Fausto, Pittion-Vouyovitch, Sophie, Danel, Veronique, Kolev, Ivan, Le Masson, Gwendal, Beltran, Stephane, Salachas, Francois, Bernard, Emilien, Pradat, Pierre-François, Blasco, Hélène, Lanznaster, Débora, Hergesheimer, Rudolph, Laumonnier, Frederic, Andres, Christian R, Meininger, Vincent, Vourc'h, Patrick

“…ObjectivesTo determine whether the familial clustering of amyotrophic lateral sclerosis (ALS) cases and the phenotype of the disease may help identify the…”
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