Search Results - "BRTKO, Július"

Thyroid hormone and thyroid hormone nuclear receptors: History and present state of art by Brtko, Julius

“…The present review traces the road leading to discovery of L-thyroxine, thyroid hormone (3,5,3´-triiodo-L-thyronine, T ) and its cognate nuclear receptors…”
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Development and Characterization of a Human Reporter Cell Line for the Assessment of Thyroid Receptor Transcriptional Activity: A Case of Organotin Endocrine Disruptors by Illés, Peter, Brtko, Július, Dvořák, Zdeněk

“…We developed and characterized the human luciferase reporter cell line PZ-TR for the assessment of thyroid receptor (TR) transcriptional activity…”
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Role of retinoids, rexinoids and thyroid hormone in the expression of cytochrome p450 enzymes by Brtko, Julius, Dvorak, Zdenek

“…Retinoic acid receptors (RARs), retinoid X receptors (RXRs) and thyroid hormone receptors (TRs) are nuclear receptors that are crucial transcriptional…”
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Genotoxic Effects of Tributyltin and Triphenyltin Isothiocyanates, Cognate RXR Ligands: Comparison in Human Breast Carcinoma MCF 7 and MDA-MB-231 Cells by Hunakova, Luba, Horvathova, Eva, Majerova, Karolina, Bobal, Pavel, Otevrel, Jan, Brtko, Julius

“…The cytotoxicity of two recently synthesized triorganotin isothiocyanate derivatives, nuclear retinoid X receptor ligands, was tested and compared in…”
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In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231 by Hunakova, Luba, Horvathova, Eva, Matuskova, Miroslava, Bobal, Pavel, Otevrel, Jan, Brtko, Julius

“…Intensive investigation for novel antiproliferative and cytotoxic effective chemical compounds is currently concentrated on structurally modified agents of…”
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Triorganotin Derivatives Induce Cell Death Effects on L1210 Leukemia Cells at Submicromolar Concentrations Independently of P-glycoprotein Expression by Bohacova, Viera, Seres, Mario, Pavlikova, Lucia, Kontar, Szilvia, Cagala, Martin, Bobal, Pavel, Otevrel, Jan, Brtko, Julius, Sulova, Zdena, Breier, Albert

“…The acceleration of drug efflux activity realized by plasma membrane transporters in neoplastic cells, particularly by P-glycoprotein (P-gp, ABCB1 member of…”
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Relationship between histology, development and tumorigenesis of mammary gland in female rat by LÍŠKA, Ján, BRTKO, Július, DUBOVICKÝ, Michal, MACEJOVÁ, Dana, KISSOVÁ, Viktória, POLÁK, Štefan, UJHÁZY, Eduard

“…The mammary gland is a dynamic organ that undergoes structural and functional changes associated with growth, reproduction, and post-menopausal regression. The…”
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A comparative study of protein patterns of human estrogen receptor positive (MCF-7) and negative (MDA-MB-231) breast cancer cell lines by Flodrova, Dana, Toporova, Lucia, Macejova, Dana, Lastovickova, Marketa, Brtko, Julius, Bobalova, Janette

“…In the present study, we analyzed the cell lysates of human tumour cell lines representing two major clinically different types of breast cancer. Our main goal…”
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Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention by BRTKO, Julius

“…Retinoids are natural and synthetic compounds related to retinoic acid that act through interaction with two basic types of nuclear receptors: retinoic acid…”
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Biological functions of kojic acid and its derivatives in medicine, cosmetics, and food industry: Insights into health aspects by Brtko, Julius

“…This review traces the road leading to the demonstration of a variety of kojic acid chemical and biological properties. It illustrates the biological effects…”
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Comparison of clavicular joints in human and laboratory rat by Líška, Ján, Zamborský, Radoslav, Maženský, Dávid, Ujházy, Eduard, Malovec, Peter, Brtko, Július, Polák, Štefan

“…The human clavicle provides the bony connection between the upper extremity and the axial skeleton and it is reported to be among the first bones ossified and…”
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Nuclear receptors - target molecules for isoflavones in cancer chemoprevention by Bialešová, Lucia, Brtko, Július, Lenko, Vladimír, Macejová, Dana

“…Breast cancer is the most occurring type of cancer among women. In Slovakia, there are yearly diagnosed about 1900 new cases of this disease. Breast cancer…”
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mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma by MACEJOVÁ, DANA, GALBAVÝ, ŠTEFAN, PODOBA, JÁN, BIALEŠOVÁ, LUCIA, BRTKO, JÚLIUS

“…Retinoids have shown potential for the inhibition of tumour growth and progression. The objective of this study was to investigate retinoic acid nuclear…”
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Natural and synthetic retinoid X receptor ligands and their role in selected nuclear receptor action by Brtko, Julius, Dvorak, Zdenek

“…Important key players in the regulatory machinery within the cells are nuclear retinoid X receptors (RXRs), which compose heterodimers in company with several…”
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MNU-induced mammary gland carcinogenesis: Chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways by Macejová, Dana, Ondková, Slavomíra, Jakubíková, Lucia, Mlynarčíková, Alžbeta, Scsuková, Soňa, Liška, Ján, Brtko, Július

“…► Vitamin D 3 and Seocalcitol as tools in prevention and therapy of mammary gland cancer. ► Seocalcitol markedly prolongs tumor latency. ► MicroPET analysis…”
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Effects of biologically active tributyl-/triphenyl-organometal ligands of retinoid X receptors in human breast cancer cell line by Macejová, Dana, Bialešová, Lucia, Toporová, Lucia, Brtko, Július

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Combined treatment of P-gp-positive L1210/VCR cells by verapamil and all- trans retinoic acid induces down-regulation of P-glycoprotein expression and transport activity by Sulová, Zdena, Macejová, Dana, Šereš, Mário, Sedlák, Ján, Brtko, Július, Breier, Albert

“…The development of the most common multidrug resistance (MDR) phenotype associated with a massive overexpression of P-glycoprotein (P-gp) in neoplastic cells…”
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Different mRNA expression profiling of nuclear retinoid, thyroid, estrogen and PPARgamma receptors, their coregulators and selected genes in rat liver and spleen in response to short-term in vivo administration of 13- cis retinoic acid by Macejová, Dana, Križanová, Oľga, Brtko, Július

“…Retinoic acids (RAs) and also their analogs (synthetic retinoids and rexinoids) have been regarded as major therapeutic and/or chemopreventive agents and can…”
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Chronic ethanol drinking and food deprivation affect rat hypothalamic-pituitary-thyroid axis and TRH in septum by Nikodémová, M, Benický, J, Brtko, J, Strbák, V

“…Because chronic ethanol ingestion may perturb thyroid function, we evaluated the effect of 4-wk of oral 10% ethanol ingestion on the…”
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Changes in retinoic acid receptor status, 5′-deiodinase activity and neuroendocrine response to voluntary wheel running by Ondkova, Slavomira, Bakos, Jan, Macejova, Dana, Jezova, Daniela, Brtko, Julius

“…Abstract Little information is available on the involvement of retinoic acid in processes related to physical activity. The aim of this study was to test the…”
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