Search Results - "BROWNRIDGE, Philip"

Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation by Hardman, Gemma, Perkins, Simon, Brownridge, Philip J, Clarke, Christopher J, Byrne, Dominic P, Campbell, Amy E, Kalyuzhnyy, Anton, Myall, Ashleigh, Eyers, Patrick A, Jones, Andrew R, Eyers, Claire E

“…Phosphorylation is a key regulator of protein function under (patho)physiological conditions, and defining site‐specific phosphorylation is essential to…”
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The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis by Nunes, Quentin M, Su, Dunhao, Brownridge, Philip J, Simpson, Deborah M, Sun, Changye, Li, Yong, Bui, Thao P, Zhang, Xiaoying, Huang, Wei, Rigden, Daniel J, Beynon, Robert J, Sutton, Robert, Fernig, David G

“…Acute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells…”
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The importance of the digest: Proteolysis and absolute quantification in proteomics by Brownridge, Philip, Beynon, Robert J.

“…► Assessment of completeness of digestion for quantitative proteomics. ► Causes and impact of incomplete digestion. ► Strategies to minimise incomplete…”
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Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α by Daly, Leonard A, Brownridge, Philip J, Batie, Michael, Rocha, Sonia, Sée, Violaine, Eyers, Claire E

“…Cellular adaptation to low-oxygen environments is mediated in part by the hypoxia-inducible factors (HIFs). Like other transcription factors, the stability and…”
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Decoding the Absolute Stoichiometric Composition and Structural Plasticity of α-Carboxysomes by Sun, Yaqi, Harman, Victoria M, Johnson, James R, Brownridge, Philip J, Chen, Taiyu, Dykes, Gregory F, Lin, Yongjun, Beynon, Robert J, Liu, Lu-Ning

“…Carboxysomes are anabolic bacterial microcompartments that play an essential role in carbon fixation in cyanobacteria and some chemoautotrophs. This…”
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Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential by Meyer, Bjoern, Chiaravalli, Jeanne, Gellenoncourt, Stacy, Brownridge, Philip, Bryne, Dominic P., Daly, Leonard A., Grauslys, Arturas, Walter, Marius, Agou, Fabrice, Chakrabarti, Lisa A., Craik, Charles S., Eyers, Claire E., Eyers, Patrick A., Gambin, Yann, Jones, Andrew R., Sierecki, Emma, Verdin, Eric, Vignuzzi, Marco, Emmott, Edward

“…SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, responsible for over 170 million infections, and over 3.7 million deaths worldwide. Efforts to…”
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Evaluation of Parameters for Confident Phosphorylation Site Localization Using an Orbitrap Fusion Tribrid Mass Spectrometer by Ferries, Samantha, Perkins, Simon, Brownridge, Philip J, Campbell, Amy, Eyers, Patrick A, Jones, Andrew R, Eyers, Claire E

“…Confident identification of sites of protein phosphorylation by mass spectrometry (MS) is essential to advance understanding of phosphorylation-mediated…”
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Custom Workflow for the Confident Identification of Sulfotyrosine-Containing Peptides and Their Discrimination from Phosphopeptides by Daly, Leonard A, Byrne, Dominic P, Perkins, Simon, Brownridge, Philip J, McDonnell, Euan, Jones, Andrew R, Eyers, Patrick A, Eyers, Claire E

“…Protein tyrosine sulfation (sY) is a post-translational modification (PTM) catalyzed by Golgi-resident tyrosyl protein sulfo transferases (TPSTs). Information…”
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cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry by Byrne, Dominic P, Vonderach, Matthias, Ferries, Samantha, Brownridge, Philip J, Eyers, Claire E, Eyers, Patrick A

“…cAMP-dependent protein kinase (PKA) is an archetypal biological signaling module and a model for understanding the regulation of protein kinases. In the…”
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Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension by Campion, Richard, Bloxam, Leanne, Burrow, Kimberley, Brownridge, Philip J, Pentland, Daniel R, Thomas, Patricia, Gourlay, Campbell W, Eyers, Claire E, Barclay, Jeff W, Morgan, Alan

“…Dietary restriction (DR) has been shown to increase lifespan in organisms ranging from yeast to mammals. This suggests that the underlying mechanisms may be…”
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Decoding the stoichiometric composition and organisation of bacterial metabolosomes by Yang, Mengru, Simpson, Deborah M., Wenner, Nicolas, Brownridge, Philip, Harman, Victoria M., Hinton, Jay C. D., Beynon, Robert J., Liu, Lu-Ning

“…Some enteric bacteria including Salmonella have evolved the propanediol-utilising microcompartment (Pdu MCP), a specialised proteinaceous organelle that is…”
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Probing the biogenesis pathway and dynamics of thylakoid membranes by Huokko, Tuomas, Ni, Tao, Dykes, Gregory F., Simpson, Deborah M., Brownridge, Philip, Conradi, Fabian D., Beynon, Robert J., Nixon, Peter J., Mullineaux, Conrad W., Zhang, Peijun, Liu, Lu-Ning

“…How thylakoid membranes are generated to form a metabolically active membrane network and how thylakoid membranes orchestrate the insertion and localization of…”
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PEPPI-MS: Polyacrylamide-Gel-Based Prefractionation for Analysis of Intact Proteoforms and Protein Complexes by Mass Spectrometry by Takemori, Ayako, Butcher, David S, Harman, Victoria M, Brownridge, Philip, Shima, Keisuke, Higo, Daisuke, Ishizaki, Jun, Hasegawa, Hitoshi, Suzuki, Junpei, Yamashita, Masakatsu, Loo, Joseph A, Loo, Rachel R. Ogorzalek, Beynon, Robert J, Anderson, Lissa C, Takemori, Nobuaki

“…Prefractionation of complex mixtures of proteins derived from biological samples is indispensable for proteome analysis via top-down mass spectrometry (MS)…”
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Attaching protein-adsorbing silica particles to the surface of cotton substrates for bioaerosol capture including SARS-CoV-2 by Collings, Kieran, Boisdon, Cedric, Sham, Tung-Ting, Skinley, Kevin, Oh, Hyun-Kyung, Prince, Tessa, Ahmed, Adham, Pennington, Shaun H., Brownridge, Philip J., Edwards, Thomas, Biagini, Giancarlo A., Eyers, Claire E., Lamb, Amanda, Myers, Peter, Maher, Simon

“…The novel coronavirus pandemic (COVID-19) has necessitated a global increase in the use of face masks to limit the airborne spread of the virus. The global…”
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Revealing mechanisms of mating plug function under sexual selection by Stockley, Paula, Franco, Catarina, Claydon, Amy J., Davidson, Amanda, Hammond, Dean E., Brownridge, Philip J., Hurst, Jane L., Beynon, Robert J.

“…Mating plugs are produced by many sexually reproducing animals and are hypothesized to promote male fertilization success under promiscuous mating. However,…”
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Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics by Byrne, Dominic P, Clarke, Christopher J, Brownridge, Philip J, Kalyuzhnyy, Anton, Perkins, Simon, Campbell, Amy, Mason, David, Jones, Andrew R, Eyers, Patrick A, Eyers, Claire E

“…Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein turnover of PLK4 are tightly…”
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Exploring the Conformational Landscape and Stability of Aurora A Using Ion-Mobility Mass Spectrometry and Molecular Modeling by Tomlinson, Lauren J, Batchelor, Matthew, Sarsby, Joscelyn, Byrne, Dominic P, Brownridge, Philip J, Bayliss, Richard, Eyers, Patrick A, Eyers, Claire E

“…Protein kinase inhibitors are highly effective in treating diseases driven by aberrant kinase signaling and as chemical tools to help dissect the cellular…”
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Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells by Hunter, Jill E, Campbell, Amy E, Kerridge, Scott, Fraser, Callum, Hannaway, Nicola L, Luli, Saimir, Ivanova, Iglika, Brownridge, Philip J, Coxhead, Jonathan, Taylor, Leigh, Leary, Peter, Hasoon, Megan S R, Eyers, Claire E, Perkins, Neil D

“…The development of resistance and the activation of bypass pathway signalling represents a major problem for the clinical application of protein kinase…”
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Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance by Hunter, Jill E, Campbell, Amy E, Butterworth, Jacqueline A, Sellier, Helene, Hannaway, Nicola L, Luli, Saimir, Floudas, Achilleas, Kenneth, Niall S, Moore, Adam J, Brownridge, Philip J, Thomas, Huw D, Coxhead, Jonathan, Taylor, Leigh, Leary, Peter, Hasoon, Megan S R, Knight, Andrew M, Garrett, Michelle D, Collins, Ian, Eyers, Claire E, Perkins, Neil D

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Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway by Hunter, Jill E, Campbell, Amy E, Hannaway, Nicola L, Kerridge, Scott, Luli, Saimir, Butterworth, Jacqueline A, Sellier, Helene, Mukherjee, Reshmi, Dhillon, Nikita, Sudhindar, Praveen D, Shukla, Ruchi, Brownridge, Philip J, Bell, Hayden L, Coxhead, Jonathan, Taylor, Leigh, Leary, Peter, Hasoon, Megan S R, Collins, Ian, Garrett, Michelle D, Eyers, Claire E, Perkins, Neil D

“…Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the…”
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