Search Results - "BROWNING, Sharon R"

Genotype Imputation with Millions of Reference Samples by Browning, Brian L., Browning, Sharon R.

“…We present a genotype imputation method that scales to millions of reference samples. The imputation method, based on the Li and Stephens model and implemented…”
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Accurate Non-parametric Estimation of Recent Effective Population Size from Segments of Identity by Descent by Browning, Sharon R., Browning, Brian L.

“…Existing methods for estimating historical effective population size from genetic data have been unable to accurately estimate effective population size during…”
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Improving the accuracy and efficiency of identity-by-descent detection in population data by Browning, Brian L, Browning, Sharon R

“…Segments of indentity-by-descent (IBD) detected from high-density genetic data are useful for many applications, including long-range phase determination,…”
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A groupwise association test for rare mutations using a weighted sum statistic by Madsen, Bo Eskerod, Browning, Sharon R

“…Resequencing is an emerging tool for identification of rare disease-associated mutations. Rare mutations are difficult to tag with SNP genotyping, as…”
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A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals by Browning, Brian L., Browning, Sharon R.

“…We present methods for imputing data for ungenotyped markers and for inferring haplotype phase in large data sets of unrelated individuals and parent-offspring…”
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Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture by Browning, Sharon R., Browning, Brian L., Zhou, Ying, Tucci, Serena, Akey, Joshua M.

“…Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one…”
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Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering by Browning, Sharon R., Browning, Brian L.

“…Whole-genome association studies present many new statistical and computational challenges due to the large quantity of data obtained. One of these challenges…”
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Detecting Identity by Descent and Estimating Genotype Error Rates in Sequence Data by Browning, Brian L., Browning, Sharon R.

“…Existing methods for identity by descent (IBD) segment detection were designed for SNP array data, not sequence data. Sequence data have a much higher density…”
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A Fast, Powerful Method for Detecting Identity by Descent by Browning, Brian L., Browning, Sharon R.

“…We present a method, fastIBD, for finding tracts of identity by descent (IBD) between pairs of individuals. FastIBD can be applied to thousands of samples…”
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High-Resolution Detection of Identity by Descent in Unrelated Individuals by Browning, Sharon R., Browning, Brian L.

“…Detection of recent identity by descent (IBD) in population samples is important for population-based linkage mapping and for highly accurate genotype…”
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Identity by Descent Between Distant Relatives: Detection and Applications by Browning, Sharon R, Browning, Brian L

“…Short segments of identity by descent (IBD) between individuals with no known relationship can be detected using genome-wide single nucleotide polymorphism…”
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Ancestry-specific recent effective population size in the Americas by Browning, Sharon R, Browning, Brian L, Daviglus, Martha L, Durazo-Arvizu, Ramon A, Schneiderman, Neil, Kaplan, Robert C, Laurie, Cathy C

“…Populations change in size over time due to factors such as population growth, migration, bottleneck events, natural disasters, and disease. The historical…”
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Population Structure Can Inflate SNP-Based Heritability Estimates by Browning, Sharon R., Browning, Brian L.

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Multilocus Association Mapping Using Variable-Length Markov Chains by Browning, Sharon R.

“…I propose a new method for association-based gene mapping that makes powerful use of multilocus data, is computationally efficient, and is straightforward to…”
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A One-Penny Imputed Genome from Next-Generation Reference Panels by Browning, Brian L., Zhou, Ying, Browning, Sharon R.

“…Genotype imputation is commonly performed in genome-wide association studies because it greatly increases the number of markers that can be tested for…”
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Fast two-stage phasing of large-scale sequence data by Browning, Brian L., Tian, Xiaowen, Zhou, Ying, Browning, Sharon R.

“…Haplotype phasing is the estimation of haplotypes from genotype data. We present a fast, accurate, and memory-efficient haplotype phasing method that scales to…”
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Protocol for detecting introgressed archaic variants with SPrime by Zhou, Ying, Browning, Sharon R.

“…The SPrime program detects the variants in current-day populations that were introgressed from an archaic source in the past. It is optimized for detecting…”
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Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans by Schick, Ursula M., Jain, Deepti, Hodonsky, Chani J., Morrison, Jean V., Davis, James P., Brown, Lisa, Sofer, Tamar, Conomos, Matthew P., Schurmann, Claudia, McHugh, Caitlin P., Nelson, Sarah C., Vadlamudi, Swarooparani, Stilp, Adrienne, Plantinga, Anna, Baier, Leslie, Bien, Stephanie A., Gogarten, Stephanie M., Laurie, Cecelia A., Taylor, Kent D., Liu, Yongmei, Auer, Paul L., Franceschini, Nora, Szpiro, Adam, Rice, Ken, Kerr, Kathleen F., Rotter, Jerome I., Hanson, Robert L., Papanicolaou, George, Rich, Stephen S., Loos, Ruth J.F., Browning, Brian L., Browning, Sharon R., Weir, Bruce S., Laurie, Cathy C., Mohlke, Karen L., North, Kari E., Thornton, Timothy A., Reiner, Alex P.

“…Platelets play an essential role in hemostasis and thrombosis. We performed a genome-wide association study of platelet count in 12,491 participants of the…”
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Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits by Sofer, Tamar, Baier, Leslie J, Browning, Sharon R, Thornton, Timothy A, Talavera, Gregory A, Wassertheil-Smoller, Sylvia, Daviglus, Martha L, Hanson, Robert, Kobes, Sayuko, Cooper, Richard S, Cai, Jianwen, Levy, Daniel, Reiner, Alex P, Franceschini, Nora

“…Admixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local…”
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A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects by Acosta-Uribe, Juliana, Aguillón, David, Cochran, J Nicholas, Giraldo, Margarita, Madrigal, Lucía, Killingsworth, Bradley W, Singhal, Rijul, Labib, Sarah, Alzate, Diana, Velilla, Lina, Moreno, Sonia, García, Gloria P, Saldarriaga, Amanda, Piedrahita, Francisco, Hincapié, Liliana, López, Hugo E, Perumal, Nithesh, Morelo, Leonilde, Vallejo, Dionis, Solano, Juan Marcos, Reiman, Eric M, Surace, Ezequiel I, Itzcovich, Tatiana, Allegri, Ricardo, Sánchez-Valle, Raquel, Villegas-Lanau, Andrés, White, 3rd, Charles L, Matallana, Diana, Myers, Richard M, Browning, Sharon R, Lopera, Francisco, Kosik, Kenneth S

“…The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish…”
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