Search Results - "BROWNING, L."

Genotype Imputation with Millions of Reference Samples by Browning, Brian L., Browning, Sharon R.

“…We present a genotype imputation method that scales to millions of reference samples. The imputation method, based on the Li and Stephens model and implemented…”
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Consideration of Cosegregation in the Pathogenicity Classification of Genomic Variants by Jarvik, Gail P., Browning, Brian L.

“…The American College of Medical Genetics and Genomics (ACMG) and Association of Molecular Pathology (AMP) recently published important new guidelines aiming to…”
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Accurate Non-parametric Estimation of Recent Effective Population Size from Segments of Identity by Descent by Browning, Sharon R., Browning, Brian L.

“…Existing methods for estimating historical effective population size from genetic data have been unable to accurately estimate effective population size during…”
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Improving the accuracy and efficiency of identity-by-descent detection in population data by Browning, Brian L, Browning, Sharon R

“…Segments of indentity-by-descent (IBD) detected from high-density genetic data are useful for many applications, including long-range phase determination,…”
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Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering by Browning, Sharon R., Browning, Brian L.

“…Whole-genome association studies present many new statistical and computational challenges due to the large quantity of data obtained. One of these challenges…”
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A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals by Browning, Brian L., Browning, Sharon R.

“…We present methods for imputing data for ungenotyped markers and for inferring haplotype phase in large data sets of unrelated individuals and parent-offspring…”
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Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture by Browning, Sharon R., Browning, Brian L., Zhou, Ying, Tucci, Serena, Akey, Joshua M.

“…Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one…”
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Genotype Imputation from Large Reference Panels by Das, Sayantan, Abecasis, Gonçalo R, Browning, Brian L

“…Genotype imputation has become a standard tool in genome-wide association studies because it enables researchers to inexpensively approximate whole-genome…”
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Detecting Identity by Descent and Estimating Genotype Error Rates in Sequence Data by Browning, Brian L., Browning, Sharon R.

“…Existing methods for identity by descent (IBD) segment detection were designed for SNP array data, not sequence data. Sequence data have a much higher density…”
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A Fast, Powerful Method for Detecting Identity by Descent by Browning, Brian L., Browning, Sharon R.

“…We present a method, fastIBD, for finding tracts of identity by descent (IBD) between pairs of individuals. FastIBD can be applied to thousands of samples…”
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Taming interfacial electronic properties of platinum nanoparticles on vacancy-abundant boron nitride nanosheets for enhanced catalysis by Zhu, Wenshuai, Wu, Zili, Foo, Guo Shiou, Gao, Xiang, Zhou, Mingxia, Liu, Bin, Veith, Gabriel M., Wu, Peiwen, Browning, Katie L., Lee, Ho Nyung, Li, Huaming, Dai, Sheng, Zhu, Huiyuan

“…Taming interfacial electronic effects on Pt nanoparticles modulated by their concomitants has emerged as an intriguing approach to optimize Pt catalytic…”
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High-Resolution Detection of Identity by Descent in Unrelated Individuals by Browning, Sharon R., Browning, Brian L.

“…Detection of recent identity by descent (IBD) in population samples is important for population-based linkage mapping and for highly accurate genotype…”
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Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma by Finkin, Shlomi, Yuan, Detian, Stein, Ilan, Taniguchi, Koji, Weber, Achim, Unger, Kristian, Browning, Jeffrey L, Goossens, Nicolas, Nakagawa, Shigeki, Gunasekaran, Ganesh, Schwartz, Myron E, Kobayashi, Masahiro, Kumada, Hiromitsu, Berger, Michael, Pappo, Orit, Rajewsky, Klaus, Hoshida, Yujin, Karin, Michael, Heikenwalder, Mathias, Ben-Neriah, Yinon, Pikarsky, Eli

“…Ectopic lymphoid structures develop at sites of chronic inflammation and are generally thought to be beneficial in the control of cancer. Pikarsky and…”
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Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors by Krautler, Nike Julia, Kana, Veronika, Kranich, Jan, Tian, Yinghua, Perera, Dushan, Lemm, Doreen, Schwarz, Petra, Armulik, Annika, Browning, Jeffrey L., Tallquist, Michelle, Buch, Thorsten, Oliveira-Martins, José B., Zhu, Caihong, Hermann, Mario, Wagner, Ulrich, Brink, Robert, Heikenwalder, Mathias, Aguzzi, Adriano

“…The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Here we show that FDC…”
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Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA by Lucifora, Julie, Xia, Yuchen, Reisinger, Florian, Zhang, Ke, Stadler, Daniela, Cheng, Xiaoming, Sprinzl, Martin F., Koppensteiner, Herwig, Makowska, Zuzanna, Volz, Tassilo, Remouchamps, Caroline, Chou, Wen-Min, Thasler, Wolfgang E., Hüser, Norbert, Durantel, David, Liang, T. Jake, Münk, Carsten, Heim, Markus H., Browning, Jeffrey L., Dejardin, Emmanuel, Dandri, Maura, Schindler, Michael, Heikenwalder, Mathias, Protzer, Ulrike

“…Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV establishes a stable nuclear covalently closed circular DNA…”
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Identity by Descent Between Distant Relatives: Detection and Applications by Browning, Sharon R, Browning, Brian L

“…Short segments of identity by descent (IBD) between individuals with no known relationship can be detected using genome-wide single nucleotide polymorphism…”
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Ancestry-specific recent effective population size in the Americas by Browning, Sharon R, Browning, Brian L, Daviglus, Martha L, Durazo-Arvizu, Ramon A, Schneiderman, Neil, Kaplan, Robert C, Laurie, Cathy C

“…Populations change in size over time due to factors such as population growth, migration, bottleneck events, natural disasters, and disease. The historical…”
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Evolutionary algorithms simulating molecular evolution: a new field proposal by Browning Jr, James S L, Tauritz, Daniel R, Beckmann, John

“…Abstract The genetic blueprint for the essential functions of life is encoded in DNA, which is translated into proteins—the engines driving most of our…”
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Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease by Browning, Jeffrey L

“…The lymphotoxin (LT) system is part of the tumor necrosis factor family and is required for lymph node development. It has provided a wonderful tool for the…”
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Population Structure Can Inflate SNP-Based Heritability Estimates by Browning, Sharon R., Browning, Brian L.

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