Search Results - "BROWNELL, H. L"

A functional assay for intercellular, junctional communication in cultured human lung carcinoma cells by Tomai, E, Brownell, H L, Tufescu, T V, Raptis, S, Reid, K, Campling, B G, Raptis, L

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Gap junctional communication in cultured human lung carcinoma cells by Tomai, Evangelia, Brownell, Heather L., Tufescu, Ted V., Reid, Kenneth, Campling, Barbara G., Raptis, Leda

“…Animal tumor models have demonstrated a close correlation between gap junctional, intercellular communication (GJIC) and tumor metastasis. To examine GJIC…”
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Cellular Ras partly mediates gap junction closure by the polyoma virus middle tumor antigen by Brownell, Heather L., Whitfield, James F., Raptis, Leda

“…Endogenous, cellular Ras proteins (c-Ras) mediate the transforming action of the polyoma virus middle Tumor antigen (mT), which is accompanied by elimination…”
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Improved procedure for electroporation of peptides into adherent cells in situ by Firth, K L, Brownell, H L, Raptis, L

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Elimination of intercellular junctional communication requires lower Ras(leu61) levels than stimulation of anchorage-independent proliferation by Brownell, H L, Whitfield, J F, Raptis, L

“…One of the effects of transformation by a variety of factors is a decrease in gap junctional, intercellular communication (GJIC). To investigate the role of…”
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Applications of electroporation of adherent cells in situ, on a partly conductive slide by RAPTIS, L. H, BROWNELL, H. L, LIU, S. K.-W, FIRTH, K. L, MACKENZIE, L. W, STILES, C. D, ALBERTA, J. A

“…Nontraumatic, simple, and reproducible procedures for the introduction of nonpermeant molecules into adherent mammalian cells by in situ electroporation are…”
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Cellular ras gene activity is required for full neoplastic transformation by the large tumor antigen of SV40 by RAPTIS, L, BROWNELL, H. L, CORBLEY, M. J, WOOD, K. W, WANG, D, HALIOTIS, T

“…To investigate the role of the cellular ras gene product in neoplastic transformation by the SV40 large tumor antigen (SVLT), murine C3H10T1/2 cells were…”
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Simian Virus 40 Large Tumor Antigen Modulates the Raf Signaling Pathway by Grammatikakis, N, Jaronczyk, K, Siganou, A, Vultur, A, Brownell, H L, Benzaquen, M, Rausch, C, Lapointe, R, Gjoerup, O, Roberts, T M, Raptis, L

“…The large tumor antigen of simian virus 40 (SVLT) is a potent oncogene. Although inactivation of the p53 and pRb tumor suppressors has been causally linked to…”
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In situ electroporation of radioactive compounds into adherent cells by Tomai, Evangelia, Vultur, Adina, Balboa, Valerie, Hsu, Tina, Brownell, Heather L, Firth, Kevin L, Raptis, Leda

“…We previously developed a technique, termed in situ electroporation, where nonpermeant molecules are introduced through an electrical pulse into adherent…”
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v-Ras and v-Raf Block Differentiation of Transformable C3H10T1/2-Derived Preadipocytes at Lower Levels Than Required for Neoplastic Transformation by Raptis, Leda, Brownell, Heather L., Lu, Ying, Preston, Thomas, Narsimhan, Radha P., Anderson, Stephen, Schaefer, Erik, Haliotis, Tina

“…To investigate the functional relationship between the transforming ability of Ras and its role as an integral component of the differentiative insulin…”
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Inhibition of epidermal growth factor-mediated ERK1/2 activation by in situ electroporation of nonpermeant [(alkylamino)methyl]acrylophenone derivatives by Brownell, H L, Lydon, N B, Schaefer, E, Roberts, T M, Raptis, L

“…The interruption of signaling cascades in intact cells through the introduction of nonpermeant compounds inferred by in vitro studies to specifically inhibit…”
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Electroporation of adherent cells in situ for the introduction of nonpermeant molecules by Raptis, L H, Firth, K L, Brownell, H L, Todd, A, Simon, W C, Bennett, B M, MacKenzie, L W, Zannis-Hadjopoulos, M

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A novel technique for the study of intercellular, junctional communication: electroporation of adherent cells on a partly conductive slide by Raptis, L H, Brownell, H L, Firth, K L, Mackenzie, L W

“…One of the effects of neoplastic transformation by a variety of factors is a decrease in gap junctional, intercellular communication (GJIC). The investigation…”
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A novel technique for the study of Ras activity: electroporation of [alpha-32P]GTP by Brownell, H L, Firth, K L, Kawauchi, K, Delovitch, T, Raptis, L

“…An efficient, simple, and reproducible procedure for the assessment of Ras activity present in adherent mammalian cells is described. [alpha-32P]GTP was…”
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Ras is involved in gap junction closure in proliferating fibroblasts or preadipocytes but not in differentiated adipocytes by Brownell, H L, Narsimhan, R P, Corbley, M J, Mann, V M, Whitfield, J F, Raptis, L

“…A decrease in gap junctional, intercellular communication (GJIC) has been associated with cells neoplastically transformed by a variety of factors. To…”
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In situ electroporation for the measurement of c-Ras activation by SVLT by Brownell, H L, Raptis, L

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Specific inhibition of growth factor-stimulated extracellular signal-regulated kinase 1 and 2 activation in intact cells by electroporation of a growth factor receptor-binding protein 2-Src homology 2 binding peptide by Raptis, L, Brownell, H L, Vultur, A M, Ross, G M, Tremblay, E, Elliott, B E

“…Activation of the Ras pathway is central to mitogenesis by a variety of growth factors such as the epidermal growth factor, platelet-derived growth factor, or…”
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Specific inhibition of growth factor-stimulated extracellular signal-regulated kinase 1 and 2 activation in intact cells by electroporation of a growth factor receptor-binding protein 2-src homology 2 binding peptide1 by RAPTIS, L, BROWNELL, H. L, VULTUR, A. M, ROSS, G. M, TREMBLAY, E, ELLIOTT, B. E

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