Search Results - "BROWN, Roger C"

From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis by SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G

“…Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described…”
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Clock-Line-Mediated Sisyphus Cooling by Chen, Chun-Chia, Siegel, Jacob L, Hunt, Benjamin D, Grogan, Tanner, Hassan, Youssef S, Beloy, Kyle, Gibble, Kurt, Brown, Roger C, Ludlow, Andrew D

“…We demonstrate subrecoil Sisyphus cooling using the long-lived ^{3}P_{0} clock state in alkaline-earth-like ytterbium. A 1388-nm optical standing wave nearly…”
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Ramsey-Bordé Matter-Wave Interferometry for Laser Frequency Stabilization at 10 − 16 Frequency Instability and Below by Olson, Judith, Fox, Richard W., Fortier, Tara M., Sheerin, Todd F., Brown, Roger C., Leopardi, Holly, Stoner, Richard E., Oates, Chris W., Ludlow, Andrew D.

“…We demonstrate Ramsey-Bordé (RB) atom interferometry for high performance laser stabilization with fractional frequency instability < 2 × 10−16 for timescales…”
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Pulsed Sisyphus scheme for laser cooling of atomic (anti)hydrogen by Wu, Saijun, Brown, Roger C, Phillips, William D, Porto, J V

“…We propose a laser cooling technique in which atoms are selectively excited to a dressed metastable state whose light shift and decay rate are spatially…”
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Multiphoton magnetooptical trap by Wu, Saijun, Plisson, Thomas, Brown, Roger C, Phillips, William D, Porto, J V

“…We demonstrate a magnetooptical trap (MOT) configuration which employs optical forces due to light scattering between electronically excited states of the…”
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QSAR and the Rational Design of Long-Acting Dual D2-Receptor/β2-Adrenoceptor Agonists by Austin, Rupert P, Barton, Patrick, Bonnert, Roger V, Brown, Roger C, Cage, Peter A, Cheshire, David R, Davis, Andrew M, Dougall, Iain G, Ince, Francis, Pairaudeau, Garry, Young, Alan

“…This paper describes the development of a QSAR model for the rational control of functional duration of topical long-acting dual D2-receptor/β2-adrenoceptor…”
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Dual D2-Receptor and β2-Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4-hydroxybenzothiazol-2(3H)-one Analogues by Bonnert, Roger V, Brown, Roger C, Chapman, David, Cheshire, David R, Dixon, John, Ince, Francis, Kinchin, Elizabeth C, Lyons, Amanda J, Davis, Andrew M, Hallam, Catherine, Harper, Stephen T, Unitt, John F, Dougall, Iain G, Jackson, Dale M, McKechnie, Kenneth, Young, Alan, Simpson, Wilfred T

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Ramsey-Bordé Matter-Wave Interferometry for Laser Frequency Stabilization at 10^{-16} Frequency Instability and Below by Olson, Judith, Fox, Richard W, Fortier, Tara M, Sheerin, Todd F, Brown, Roger C, Leopardi, Holly, Stoner, Richard E, Oates, Chris W, Ludlow, Andrew D

“…We demonstrate Ramsey-Bordé (RB) atom interferometry for high performance laser stabilization with fractional frequency instability <2×10^{-16} for timescales…”
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Erratum: Absolute Transition Frequencies and Quantum Interference in a Frequency Comb Based Measurement of the Li 6 , 7 D Lines [Phys. Rev. Lett. 107 , 023001 (2011)] by Sansonetti, Craig J., Simien, C. E., Gillaspy, J. D., Tan, Joseph N., Brewer, Samuel M., Brown, Roger C., Wu, Saijun, Porto, J. V.

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Absolute Transition Frequencies and Quantum Interference in a Frequency Comb Based Measurement of the Li 6 , 7 D Lines by Sansonetti, Craig J., Simien, C. E., Gillaspy, J. D., Tan, Joseph N., Brewer, Samuel M., Brown, Roger C., Wu, Saijun, Porto, J. V.

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Design, synthesis, and physicochemical properties of a novel, conformationally restricted 2,3-dihydro-1,3,4-thiadiazole-containing angiotensin converting enzyme inhibitor which is preferentially eliminated by the biliary route in rats by Bennion, Colin, Brown, Roger C, Cook, Anthony R, Manners, Carol N, Payling, David W, Robinson, David H

“…Two novel series of dihydrothiadiazole ring containing inhibitors of angiotensin converting enzyme have been designed and synthesized. The compounds are highly…”
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Some Developments in the High Temperature Gas Phase Chemistry of Alkynes, Arynes and Aryl Radicals by C. Brown, Roger F.

“…The discovery of the equilibration of alkynes with ylidenecarbenes at high temperatures has been followed by increasing use of the reactivity of such carbenes…”
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Clock-line-mediated Sisyphus Cooling by Chen, Chun-Chia, Siegel, Jacob L, Hunt, Benjamin D, Grogan, Tanner, Hassan, Youssef S, Beloy, Kyle, Gibble, Kurt, Brown, Roger C, Ludlow, Andrew D

“…Phys. Rev. Lett. 133, 053401 (2024) We demonstrate sub-recoil Sisyphus cooling using the long-lived $^{3}\mathrm{P}_{0}$ clock state in alkaline-earth-like…”
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Very-high- and ultrahigh- frequency electric field detection using high angular momentum Rydberg states by Brown, Roger C, Kayim, Baran, Viray, Michael A, Perry, Abigail R, Sawyer, Brian C, Wyllie, Robert

“…Phys. Rev. A 107, 052605 (2023) We demonstrate resonant detection of rf electric fields from 240 MHz to 900 MHz (very-high-frequency (VHF) to…”
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Lattice Light Shift Evaluations In a Dual-Ensemble Yb Optical Lattice Clock by Bothwell, Tobias, Hunt, Benjamin D, Siegel, Jacob L, Hassan, Youssef S, Grogan, Tanner, Kobayashi, Takumi, Gibble, Kurt, Porsev, Sergey G, Safronova, Marianna S, Brown, Roger C, Beloy, Kyle, Ludlow, Andrew D

“…In state-of-the-art optical lattice clocks, beyond-electric-dipole polarizability terms lead to a break-down of magic wavelength trapping. In this Letter, we…”
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Absolute transition frequencies and quantum interference in a frequency comb based measurement of the (6,7)Li D lines by Sansonetti, Craig J, Simien, C E, Gillaspy, J D, Tan, Joseph N, Brewer, Samuel M, Brown, Roger C, Wu, Saijun, Porto, J V

“…Optical frequencies of the D lines of (6,7)Li were measured with a relative accuracy of 5 × 10⁻¹¹ using an optical comb synthesizer. Quantum interference in…”
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From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis by Springthorpe, Brian, Bailey, Andrew, Barton, Patrick, Birkinshaw, Timothy N., Bonnert, Roger V., Brown, Roger C., Chapman, David, Dixon, John, Guile, Simon D., Humphries, Robert G., Hunt, Simon F., Ince, Francis, Ingall, Anthony H., Kirk, Ian P., Leeson, Paul D., Leff, Paul, Lewis, Richard J., Martin, Barrie P., McGinnity, Dermot F., Mortimore, Michael P., Paine, Stuart W., Pairaudeau, Garry, Patel, Anil, Rigby, Aaron J., Riley, Robert J., Teobald, Barry J., Tomlinson, Wendy, Webborn, Peter J.H., Willis, Paul A.

“…Starting with ATP, the identification of novel P2Y 12 receptor antagonists are described. The leading compound, 17 (AZD6140), is currently in a phase III…”
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Erratum: Quantum interference and light polarization effects in unresolvable atomic lines: Application to a precise measurement of the 6 , 7 Li D 2 lines [Phys. Rev. A 87 , 032504 (2013)] by Brown, Roger C., Wu, Saijun, Porto, J. V., Sansonetti, Craig J., Simien, C. E., Brewer, Samuel M., Tan, Joseph N., Gillaspy, J. D.

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Ramsey-Bord\'e matter-wave interferometry for laser frequency stabilization at $10^{-16}$ frequency instability and below by Olson, Judith, Fox, Richard W, Fortier, Tara M, Sheerin, Todd F, Brown, Roger C, Leopardi, Holly, Stoner, Richard E, Oates, Chris W, Ludlow, Andrew D

“…We demonstrate Ramsey-Bord\'e (RB) atom interferometry for high performance laser stabilization with fractional frequency instability $<2 \times 10^{-16}$ for…”
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Quantum interference and light polarization effects in unresolvable atomic lines: Application to a precise measurement of the 6 , 7 Li D 2 lines by Brown, Roger C., Wu, Saijun, Porto, J. V., Sansonetti, Craig J., Simien, C. E., Brewer, Samuel M., Tan, Joseph N., Gillaspy, J. D.

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