Search Results - "BROWN, Nadine M"

The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones by Setchell, Kenneth D R, Brown, Nadine M, Lydeking-Olsen, Eva

“…Equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman] is a nonsteroidal estrogen of the isoflavone class. It is exclusively a product of intestinal bacterial…”
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Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk by DR SETCHELL, Kenneth, BROWN, Nadine M, XUEHENG ZHAO, LINDLEY, Stephanie L, HEUBI, James E, KING, Eileen C, MESSINA, Mark J

“…Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences…”
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Dietary factors influence production of the soy isoflavone metabolite s-(-)equol in healthy adults by Setchell, Kenneth D R, Brown, Nadine M, Summer, Suzanne, King, Eileen C, Heubi, James E, Cole, Sidney, Guy, Trish, Hokin, Bevan

“…S-(-)equol, an intestinally derived metabolite of the soy isoflavone daidzein, is proposed to enhance the efficacy of soy diets. Adults differ in their ability…”
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Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability by Setchell, Kenneth D.R, Brown, Nadine M, Zimmer-Nechemias, Linda, Brashear, Wayne T, Wolfe, Brian E, Kirschner, Abby S, Heubi, James E

“…Background: The isoflavones daidzein and genistein occur naturally in most soyfoods, conjugated almost exclusively to sugars. Controversy exists regarding the…”
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Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans by Setchell, Kenneth D R, Brown, Nadine M, Zimmer-Nechemias, Linda, Wolfe, Brian, Jha, Pinky, Heubi, James E

“…Secoisolariciresinol-diglycoside (SDG), a natural dietary lignan of flaxseeds now available in dietary supplements, is converted by intestinal bacteria to the…”
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Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements by Setchell, K D, Brown, N M, Desai, P, Zimmer-Nechemias, L, Wolfe, B E, Brashear, W T, Kirschner, A S, Cassidy, A, Heubi, J E

“…The pharmacokinetic behavior of naturally occurring isoflavones has been determined for the first time in healthy adults. We compared plasma kinetics of pure…”
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S-Equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora by Setchell, K.D.R, Clerici, C, Lephart, E.D, Cole, S.J, Heenan, C, Castellani, D, Wolfe, B.E, Nechemias-Zimmer, L, Brown, N.M, Lund, T.D

“…Background: The discovery of equol in human urine more than 2 decades ago and the finding that it is bacterially derived from daidzin, an isoflavone abundant…”
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pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers by Setchell, Kenneth DR, Zhao, Xueheng, Jha, Pinky, Heubi, James E, Brown, Nadine M

“…BACKGROUND: The nonsteroidal estrogen equol occurs as diastereoisomers, S-(-)equol and R-(+)equol, both of which have significant biological actions…”
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Animal Models Impacted by Phytoestrogens in Commercial Chow: Implications for Pathways Influenced by Hormones by Brown, Nadine M, Setchell, Kenneth D R

“…It is generally not known that most commercial rodent diets are formulated with soy protein and deliver large daily doses of isoflavones to animals throughout…”
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The Estrogenic Content of Rodent Diets, Bedding, Cages, and Water Bottles and Its Effect on Bisphenol A Studies by Thigpen, Julius E, Setchell, Kenneth DR, Kissling, Grace E, Locklear, Jacqueline, Caviness, Gordon F, Whiteside, Tanya, Belcher, Scott M, Brown, Nadine M, Collins, Bradley J, Lih, Fred B, Tomer, Kenneth B, Padilla-Banks, Elizabeth, Camacho, Luísa, Adsit, Floyd G, Grant, Mary

“…The lowest observed adverse effect level for bisphenol A (BPA) in mice and rats is currently poorly defined due to inconsistent study designs and results in…”
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S -(−)equol production is developmentally regulated and related to early diet composition by Brown, Nadine M, Galandi, Stephanie L, Summer, Suzanne S, Zhao, Xueheng, Heubi, James E, King, Eileen C, Setchell, Kenneth D.R

“…Abstract S -(−)7-hydroxy-3-(4′-hydroxyphenyl)-chroman, or S -(−)equol, a biologically active intestinally derived bacterial metabolite of the soy isoflavones…”
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The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer by Brown, Nadine M., Belles, Carrie A., Lindley, Stephanie L., Zimmer-Nechemias, Linda D., Zhao, Xueheng, Witte, David P., Kim, Mi-Ok, Setchell, Kenneth D.R.

“…We describe for the first time the chemopreventive effects of S-(−)equol and R-(+)equol, diastereoisomers with contrasting affinities for estrogen receptors…”
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Impact of perinatal exposure to equol enantiomers on reproductive development in rodents by Brown, Nadine M., Lindley, Stephanie L., Witte, David P., Setchell, Kenneth D.R.

“…There is now considerable interest in the intestinally derived soy isoflavone metabolite, equol, which occurs in the enantiomeric forms, S-(−)equol and…”
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Prenatal TCDD and predisposition to mammary cancer in the rat by BROWN, N. M, MANZOLILLO, P. A, ZHANG, J.-X, JUN WANG, LAMARTINIERE, C. A

“…Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated for its potential to predispose to breast cancer. Analysis of mammary gland…”
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Pharmacokinetics of a Slow-Release Formulation of Soybean Isoflavones in Healthy Postmenopausal Women by Setchell, Kenneth D. R, Brzezinski, Amnon, Brown, Nadine M, Desai, Pankaj B, Melhem, Murad, Meredith, Trevor, Zimmer-Nechimias, Linda, Wolfe, Brian, Cohen, Yoram, Blatt, Yoav

“…Pharmacokinetic studies of soybean isoflavones have shown that following oral ingestion, the two major isoflavones, daidzin and genistin, are hydrolyzed in the…”
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Xenoestrogens Alter Mammary Gland Differentiation and Cell Proliferation in the Rat by Brown, Nadine M., Lamartiniere, Coral A.

“…We investigated mammary gland differentiation and cell proliferation in rats after acute exposure to xenoestrogens. Pubertal female Sprague-Dawley rats…”
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MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION: Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats by Murrill, W.Britton, Brown, Nadine M., Zhang, Jun-Xuan, Manzolillo, Patricia A., Barnes, Stephen, Lamartiniere, Coral A.

“…Genistein, a component of soy, was administered to pre-pubertal female Sprague-Dawley CD rats and investigated for chemoprevention against mammary cancer…”
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Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk1234 by Setchell, Kenneth DR, Brown, Nadine M, Zhao, Xueheng, Lindley, Stephanie L, Heubi, James E, King, Eileen C, Messina, Mark J

“…Background: Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to…”
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The pharmacokinetic behavior of the soy isoflavone metabolite S-(-)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers23 by Setchell, Kenneth DR, Zhao, Xueheng, Jha, Pinky, Heubi, James E, Brown, Nadine M

“…Background:The nonsteroidal estrogen equol occurs as diastereoisomers, S-()equol and R-(+)equol, both of which have significant biological actions. S-()equol,…”
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The pharmacokinetic behavior of the soy isoflavone metabolite S-(−)equol and its diastereoisomer R-(+)equol in healthy adults determined by using stable-isotope-labeled tracers1234 by Setchell, Kenneth DR, Zhao, Xueheng, Jha, Pinky, Heubi, James E, Brown, Nadine M

“…Background: The nonsteroidal estrogen equol occurs as diastereoisomers, S -(−)equol and R -(+)equol, both of which have significant biological actions. S…”
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