Search Results - "BROWN, M. K"

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer by Kreso, Antonija, O'Brien, Catherine A., van Galen, Peter, Gan, Olga I., Notta, Faiyaz, Brown, Andrew M. K., Ng, Karen, Ma, Jing, Wienholds, Erno, Dunant, Cyrille, Pollett, Aaron, Gallinger, Steven, McPherson, John, Mullighan, Charles G., Shibata, Darryl, Dick, John E.

“…Intratumoral heterogeneity arises through the evolution of genetically diverse subclones during tumor progression. However, it remains unknown whether cells…”
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Improving plant transient expression through the rational design of synthetic 5' and 3' untranslated regions by Peyret, Hadrien, Brown, James K M, Lomonossoff, George P

“…The growing field of plant molecular farming relies on expression vectors that allow high yields of recombinant proteins to be produced through transient gene…”
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Basal root whorl number: a modulator of phosphorus acquisition in common bean (Phaseolus vulgaris) by Miguel, M. A, Widrig, A, Vieira, R. F, Brown, K. M, Lynch, J. P

“…Background and AimsRoot architectural phenes enhancing topsoil foraging are important for phosphorus acquisition. In this study, the utility of a novel phene…”
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The genotype of barley cultivars influences multiple aspects of their associated microbiota via differential root exudate secretion by Pacheco-Moreno, Alba, Bollmann-Giolai, Anita, Chandra, Govind, Brett, Paul, Davies, Jack, Thornton, Owen, Poole, Philip, Ramachandran, Vinoy, Brown, James K M, Nicholson, Paul, Ridout, Chris, DeVos, Sarah, Malone, Jacob G

“…Plant-associated microbes play vital roles in promoting plant growth and health, with plants secreting root exudates into the rhizosphere to attract beneficial…”
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trade off between mlo resistance to powdery mildew and increased susceptibility of barley to a newly important disease, Ramularia leaf spot by McGrann, Graham R. D, Stavrinides, Anna, Russell, Joanne, Corbitt, Margaret M, Booth, Allan, Chartrain, Laetitia, Thomas, William T. B, Brown, James K. M

“…Ramularia leaf spot (RLS), caused by the fungus Ramularia collo-cygni, is a serious, recently emerged disease of barley in Europe and other temperate regions…”
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Selenium, selenoproteins and human health: a review by Brown, KM, Arthur, JR

“…Selenium is of fundamental importance to human health. It is an essential component of several major metabolic pathways, including thyroid hormone metabolism,…”
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An optimised CRISPR Cas9 and Cas12a mutagenesis toolkit for Barley and Wheat by Lawrenson, Tom, Clarke, Martha, Kirby, Rachel, Forner, Macarena, Steuernagel, Burkhard, Brown, James K M, Harwood, Wendy

“…CRISPR Cas9 and Cas12a are the two most frequently used programmable nucleases reported in plant systems. There is now a wide range of component parts for both…”
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Searching for rigour in the reporting of mixed methods population health research: a methodological review by Brown, K. M., Elliott, S. J., Leatherdale, S. T., Robertson-Wilson, J.

“…The environments in which population health interventions occur shape both their implementation and outcomes. Hence, when evaluating these interventions, we…”
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Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children by VISSCHER, Henk, ROSS, Colin J. D, DER PAL, Helena J. Van, BROWN, Andrew M. K, ROGERS, Paul C, PHILLIPS, Michael S, RIEDER, Michael J, CARLETON, Bruce C, HAYDEN, Michael R, ROD RASSEKH, S, BARHDADI, Amina, DUBE, Marie-Pierre, AL-SALOOS, Hesham, SANDOR, George S, CARON, Huib N, DALEN, Elvira C. Van, KREMER, Leontien C

“…Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting anthracycline use and causing substantial morbidity and mortality. Our…”
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Aerial Dispersal of Pathogens on the Global and Continental Scales and Its Impact on Plant Disease by Brown, James K.M, Hovmoller, Mogens S

“…Some of the most striking and extreme consequences of rapid, long-distance aerial dispersal involve pathogens of crop plants. Long-distance dispersal of fungal…”
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Supportive care needs and preferences of lung cancer patients: a semi-structured qualitative interview study by Brown, Natasha M. K., Lui, Chi-Wai, Robinson, Peter C., Boyle, Frances M.

“…Purpose Lung cancer patients report both high levels of unmet supportive care need and underutilisation of support services, but the existing literature offers…”
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Regulation of root hair density by phosphorus availability in Arabidopsis thaliana by Ma, Z., Bielenberg, D. G., Brown, K. M., Lynch, J. P.

“…ABSTRACT We characterized the response of root hair density to phosphorus (P) availability in Arabidopsis thaliana. Arabidopsis plants were grown aseptically…”
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A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns by Notta, Faiyaz, Chan-Seng-Yue, Michelle, Lemire, Mathieu, Li, Yilong, Wilson, Gavin W., Connor, Ashton A., Denroche, Robert E., Liang, Sheng-Ben, Brown, Andrew M. K., Kim, Jaeseung C., Wang, Tao, Simpson, Jared T., Beck, Timothy, Borgida, Ayelet, Buchner, Nicholas, Chadwick, Dianne, Hafezi-Bakhtiari, Sara, Dick, John E., Heisler, Lawrence, Hollingsworth, Michael A., Ibrahimov, Emin, Jang, Gun Ho, Johns, Jeremy, Jorgensen, Lars G. T., Law, Calvin, Ludkovski, Olga, Lungu, Ilinca, Ng, Karen, Pasternack, Danielle, Petersen, Gloria M., Shlush, Liran I., Timms, Lee, Tsao, Ming-Sound, Wilson, Julie M., Yung, Christina K., Zogopoulos, George, Bartlett, John M. S., Alexandrov, Ludmil B., Real, Francisco X., Cleary, Sean P., Roehrl, Michael H., McPherson, John D., Stein, Lincoln D., Hudson, Thomas J., Campbell, Peter J., Gallinger, Steven

“…Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in…”
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Coevolution between a family of parasite virulence effectors and a class of LINE-1 retrotransposons by Sacristán, Soledad, Vigouroux, Marielle, Pedersen, Carsten, Skamnioti, Pari, Thordal-Christensen, Hans, Micali, Cristina, Brown, James K M, Ridout, Christopher J

“…Parasites are able to evolve rapidly and overcome host defense mechanisms, but the molecular basis of this adaptation is poorly understood. Powdery mildew…”
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The Influence of Perenniality and Seed Banks on Polymorphism in Plant‐Parasite Interactions by Tellier, Aurélien, Brown, James K. M.

“…Antagonistic interactions, such as diseases, play an important role in natural populations. Understanding the mechanisms that promote long‐term polymorphism at…”
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Evolution of the EKA family of powdery mildew avirulence-effector genes from the ORF 1 of a LINE retrotransposon by Amselem, Joelle, Vigouroux, Marielle, Oberhaensli, Simone, Brown, James K M, Bindschedler, Laurence V, Skamnioti, Pari, Wicker, Thomas, Spanu, Pietro D, Quesneville, Hadi, Sacristán, Soledad

“…The Avrk1 and Avra10 avirulence (AVR) genes encode effectors that increase the pathogenicity of the fungus Blumeria graminis f.sp. hordei (Bgh), the powdery…”
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Feasibility of real time next generation sequencing of cancer genes linked to drug response: Results from a clinical trial by Tran, Ben, Brown, Andrew M.K., Bedard, Philippe L., Winquist, Eric, Goss, Glenwood D., Hotte, Sebastien J., Welch, Stephen A., Hirte, Hal W., Zhang, Tong, Stein, Lincoln D., Ferretti, Vincent, Watt, Stuart, Jiao, Wei, Ng, Karen, Ghai, Sangeet, Shaw, Patricia, Petrocelli, Teresa, Hudson, Thomas J., Neel, Benjamin G., Onetto, Nicole, Siu, Lillian L., McPherson, John D., Kamel‐Reid, Suzanne, Dancey, Janet E.

“…The successes of targeted drugs with companion predictive biomarkers and the technological advances in gene sequencing have generated enthusiasm for evaluating…”
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Plant-Parasite Coevolution: Bridging the Gap between Genetics and Ecology by Brown, James K.M, Tellier, Aurélien

“…We review current ideas about coevolution of plants and parasites, particularly processes that generate genetic diversity. Frequencies of host resistance and…”
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Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa by Woodcock, Stuart D, Syson, Karl, Little, Richard H, Ward, Danny, Sifouna, Despoina, Brown, James K M, Bornemann, Stephen, Malone, Jacob G

“…An important prelude to bacterial infection is the ability of a pathogen to survive independently of the host and to withstand environmental stress. The…”
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A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma by Wadt, K.A.W., Aoude, L.G., Johansson, P., Solinas, A., Pritchard, A., Crainic, O., Andersen, M.T., Kiilgaard, J.F., Heegaard, S., Sunde, L., Federspiel, B., Madore, J., Thompson, J.F., McCarthy, S.W., Goodwin, A., Tsao, H., Jönsson, G., Busam, K., Gupta, R., Trent, J.M., Gerdes, A.-M., Brown, K.M., Scolyer, R.A., Hayward, N.K.

“…We report four previously undescribed families with germline BRCA1‐associated protein‐1 gene (BAP1) mutations and expand the clinical phenotype of this tumor…”
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