Search Results - "BROWN, H. Alex"

Targeting phospholipase D in cancer, infection and neurodegenerative disorders by Brown, H. Alex, Thomas, Paul G., Lindsley, Craig W.

“…Key Points Phospholipase D (PLD) enzymes are one source of receptor-generated phosphatidic acid (PtdOH),which may subsequently be metabolized to diacylglycerol…”
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Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer by Bruntz, Ronald C, Lindsley, Craig W, Brown, H Alex

“…Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an intracellular signaling species. The phospholipase D superfamily plays…”
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Phospholipase D: Enzymology, Functionality, and Chemical Modulation by Selvy, Paige E, Lavieri, Robert R, Lindsley, Craig W, Brown, H. Alex

“…Selvy et al examine the chemical modulation, functionality and enzymology of phospholipase D…”
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Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase by Kumari, Manju, Schoiswohl, Gabriele, Chitraju, Chandramohan, Paar, Margret, Cornaciu, Irina, Rangrez, Ashraf Y., Wongsiriroj, Nuttaporn, Nagy, Harald M., Ivanova, Pavlina T., Scott, Sarah A., Knittelfelder, Oskar, Rechberger, Gerald N., Birner-Gruenberger, Ruth, Eder, Sandra, Brown, H. Alex, Haemmerle, Guenter, Oberer, Monika, Lass, Achim, Kershaw, Erin E., Zimmermann, Robert, Zechner, Rudolf

“…Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis…”
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Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions by Sohn, Mira, Ivanova, Pavlina, Brown, H. Alex, Toth, Daniel J., Varnai, Peter, Kim, Yeun Ju, Balla, Tamas

“…Lenz-Majewski syndrome (LMS) is a rare disease characterized by complex craniofacial, dental, cutaneous, and limb abnormalities combined with intellectual…”
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Working towards an exegesis for lipids in biology by Brown, H Alex, Murphy, Robert C

“…As a field, lipidomics is in its infancy, yet it has already begun to influence lipid biochemistry in myriad ways. As with other omic technologies, the field…”
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Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells[S] by Leamy, Alexandra K., Egnatchik, Robert A., Shiota, Masakazu, Ivanova, Pavlina T., Myers, David S., Brown, H. Alex, Young, Jamey D.

“…High levels of saturated FAs (SFAs) are acutely toxic to a variety of cell types, including hepatocytes, and have been associated with diseases such as type 2…”
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Introduction to Lipid Biochemistry, Metabolism, and Signaling by Brown, H Alex, Marnett, Lawrence J

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Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model by Gorden, D Lee, Ivanova, Pavlina T, Myers, David S, McIntyre, J Oliver, VanSaun, Michael N, Wright, J Kelly, Matrisian, Lynn M, Brown, H Alex

“…The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and progression to cirrhosis. While…”
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Phospholipase D2 Mediates Survival Signaling through Direct Regulation of Akt in Glioblastoma Cells by Bruntz, Ronald C., Taylor, Harry E., Lindsley, Craig W., Brown, H. Alex

“…The lack of innovative drug targets for glioblastoma multiforme (GBM) limits patient survival to approximately 1 year following diagnosis. The pro-survival…”
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Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches by Shakya, Sajina, Gromovsky, Anthony D, Hale, James S, Knudsen, Arnon M, Prager, Briana, Wallace, Lisa C, Penalva, Luiz O F, Brown, H Alex, Kristensen, Bjarne W, Rich, Jeremy N, Lathia, Justin D, Brown, J Mark, Hubert, Christopher G

“…Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has…”
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Lipidomics: when apocrypha becomes canonical by Alex Brown, H

“…[Display omitted] ► Lipidomics has developed well established methodologies and updated nomenclature. ► Several major challenges lie ahead for the field of…”
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Lipidomics: An analysis of cellular lipids by ESI-MS by Milne, Stephen, Ivanova, Pavlina, Forrester, Jeffrey, Alex Brown, H.

“…Recognition of the importance of lipid signaling in cellular function has led to rapid progress in the technology of lipid analysis. Measurements of lipid…”
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Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target by Beavers, William N, Rose, Kristie L, Galligan, James J, Mitchener, Michelle M, Rouzer, Carol A, Tallman, Keri A, Lamberson, Connor R, Wang, Xiaojing, Hill, Salisha, Ivanova, Pavlina T, Brown, H. Alex, Zhang, Bing, Porter, Ned A, Marnett, Lawrence J

“…Determining the impact of lipid electrophile-mediated protein damage that occurs during oxidative stress requires a comprehensive analysis of electrophile…”
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FAM83B mediates EGFR- and RAS-driven oncogenic transformation by Cipriano, Rocky, Graham, James, Miskimen, Kristy L S, Bryson, Benjamin L, Bruntz, Ronald C, Scott, Sarah A, Brown, H Alex, Stark, George R, Jackson, Mark W

“…Aberrant regulation of growth signaling is a hallmark of cancer development that often occurs through the constitutive activation of growth factor receptors or…”
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Quantitative analysis of glycerophospholipids by LC–MS: Acquisition, data handling, and interpretation by Myers, David S., Ivanova, Pavlina T., Milne, Stephen B., Brown, H. Alex

“…As technology expands what it is possible to accurately measure, so too the challenges faced by modern mass spectrometry applications expand. A high level of…”
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Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation[S] by Burnum, Kristin E., Cornett, Dale S., Puolitaival, Satu M., Milne, Stephen B., Myers, David S., Tranguch, Susanne, Brown, H. Alex, Dey, Sudhansu K., Caprioli, Richard M.

“…Molecular events involved in successful embryo implantation are not well understood. In this study, we used MALDI imaging mass spectrometry (IMS) technologies…”
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Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster by Faust, Joseph E, Manisundaram, Arvind, Ivanova, Pavlina T, Milne, Stephen B, Summerville, James B, Brown, H Alex, Wangler, Michael, Stern, Michael, McNew, James A

“…Peroxisomes are ubiquitous organelles that perform lipid and reactive oxygen species metabolism. Defects in peroxisome biogenesis cause peroxisome biogenesis…”
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Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency by Kim, Seok-Hyung, Scott, Sarah A, Bennett, Michael J, Carson, Robert P, Fessel, Joshua, Brown, H Alex, Ess, Kevin C

“…Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) is a severe mitochondrial disorder featuring multi-organ dysfunction. Mutations in either the ETFA, ETFB, and…”
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Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress by Liu, Sean T.H, Sharon-Friling, Ronit, Ivanova, Pavlina, Milne, Stephen B, Myers, David S, Rabinowitz, Joshua D, Brown, H. Alex, Shenk, Thomas

“…Human cytomegalovirus induces and requires fatty acid synthesis. This suggests an essential role for lipidome remodeling in viral replication. We used mass…”
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