Search Results - "BROWN, Christopher T"

Measurement of bacterial replication rates in microbial communities by Brown, Christopher T, Olm, Matthew R, Thomas, Brian C, Banfield, Jillian F

“…Replication rates of bacteria in both human and environmental microbiomes are measured without reference genome sequences. Culture-independent microbiome…”
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Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations by Castelle, Cindy J., Brown, Christopher T., Anantharaman, Karthik, Probst, Alexander J., Huang, Raven H., Banfield, Jillian F.

“…Candidate phyla radiation (CPR) bacteria and DPANN (an acronym of the names of the first included phyla) archaea are massive radiations of organisms that are…”
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Unusual biology across a group comprising more than 15% of domain Bacteria by Brown, Christopher T., Hug, Laura A., Thomas, Brian C., Sharon, Itai, Castelle, Cindy J., Singh, Andrea, Wilkins, Michael J., Wrighton, Kelly C., Williams, Kenneth H., Banfield, Jillian F.

“…More than 15% of the bacterial domain consists of a radiation of phyla about which very little is known; here, metagenomics is used to reconstruct 8 complete…”
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Genomic expansion of domain archaea highlights roles for organisms from new phyla in anaerobic carbon cycling by Castelle, Cindy J, Wrighton, Kelly C, Thomas, Brian C, Hug, Laura A, Brown, Christopher T, Wilkins, Michael J, Frischkorn, Kyle R, Tringe, Susannah G, Singh, Andrea, Markillie, Lye Meng, Taylor, Ronald C, Williams, Kenneth H, Banfield, Jillian F

“…Archaea represent a significant fraction of Earth's biodiversity, yet they remain much less well understood than Bacteria. Gene surveys, a few metagenomic…”
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Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system by Anantharaman, Karthik, Brown, Christopher T., Hug, Laura A., Sharon, Itai, Castelle, Cindy J., Probst, Alexander J., Thomas, Brian C., Singh, Andrea, Wilkins, Michael J., Karaoz, Ulas, Brodie, Eoin L., Williams, Kenneth H., Hubbard, Susan S., Banfield, Jillian F.

“…The subterranean world hosts up to one-fifth of all biomass, including microbial communities that drive transformations central to Earth’s biogeochemical…”
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Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes by Brown, Christopher T, Davis-Richardson, Austin G, Giongo, Adriana, Gano, Kelsey A, Crabb, David B, Mukherjee, Nabanita, Casella, George, Drew, Jennifer C, Ilonen, Jorma, Knip, Mikael, Hyöty, Heikki, Veijola, Riitta, Simell, Tuula, Simell, Olli, Neu, Josef, Wasserfall, Clive H, Schatz, Desmond, Atkinson, Mark A, Triplett, Eric W

“…Recent studies have suggested a bacterial role in the development of autoimmune disorders including type 1 diabetes (T1D). Over 30 billion nucleotide bases of…”
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Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems by Burstein, David, Sun, Christine L., Brown, Christopher T., Sharon, Itai, Anantharaman, Karthik, Probst, Alexander J., Thomas, Brian C., Banfield, Jillian F.

“…Current understanding of microorganism–virus interactions, which shape the evolution and functioning of Earth’s ecosystems, is based primarily on cultivated…”
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Genomic resolution of a cold subsurface aquifer community provides metabolic insights for novel microbes adapted to high CO2 concentrations by Probst, Alexander J., Castelle, Cindy J., Singh, Andrea, Brown, Christopher T., Anantharaman, Karthik, Sharon, Itai, Hug, Laura A., Burstein, David, Emerson, Joanne B., Thomas, Brian C., Banfield, Jillian F.

“…Summary As in many deep underground environments, the microbial communities in subsurface high‐CO2 ecosystems remain relatively unexplored. Recent…”
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Identical bacterial populations colonize premature infant gut, skin, and oral microbiomes and exhibit different in situ growth rates by Olm, Matthew R, Brown, Christopher T, Brooks, Brandon, Firek, Brian, Baker, Robyn, Burstein, David, Soenjoyo, Karina, Thomas, Brian C, Morowitz, Michael, Banfield, Jillian F

“…The initial microbiome impacts the health and future development of premature infants. Methodological limitations have led to gaps in our understanding of the…”
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A new view of the tree of life by Hug, Laura A., Baker, Brett J., Anantharaman, Karthik, Brown, Christopher T., Probst, Alexander J., Castelle, Cindy J., Butterfield, Cristina N., Hernsdorf, Alex W., Amano, Yuki, Ise, Kotaro, Suzuki, Yohey, Dudek, Natasha, Relman, David A., Finstad, Kari M., Amundson, Ronald, Thomas, Brian C., Banfield, Jillian F.

“…The tree of life is one of the most important organizing principles in biology 1 . Gene surveys suggest the existence of an enormous number of branches 2 , but…”
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Structure of bone morphogenetic protein 9 procomplex by Mi, Li-Zhi, Brown, Christopher T., Gao, Yijie, Tian, Yuan, Le, Viet Q., Walz, Thomas, Springer, Timothy A.

“…Bone morphogenetic proteins (BMPs) belong to the TGF-β family, whose 33 members regulate multiple aspects of morphogenesis. TGF-β family members are secreted…”
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Unusual respiratory capacity and nitrogen metabolism in a Parcubacterium (OD1) of the Candidate Phyla Radiation by Castelle, Cindy J., Brown, Christopher T., Thomas, Brian C., Williams, Kenneth H., Banfield, Jillian F.

“…The Candidate Phyla Radiation (CPR) is a large group of bacteria, the scale of which approaches that of all other bacteria. CPR organisms are inferred to…”
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Aquifer environment selects for microbial species cohorts in sediment and groundwater by Hug, Laura A, Thomas, Brian C, Brown, Christopher T, Frischkorn, Kyle R, Williams, Kenneth H, Tringe, Susannah G, Banfield, Jillian F

“…Little is known about the biogeography or stability of sediment-associated microbial community membership because these environments are biologically complex…”
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RubisCO of a nucleoside pathway known from Archaea is found in diverse uncultivated phyla in bacteria by Wrighton, Kelly C, Castelle, Cindy J, Varaljay, Vanessa A, Satagopan, Sriram, Brown, Christopher T, Wilkins, Michael J, Thomas, Brian C, Sharon, Itai, Williams, Kenneth H, Tabita, F Robert, Banfield, Jillian F

“…Metagenomic studies recently uncovered form II/III RubisCO genes, originally thought to only occur in archaea, from uncultivated bacteria of the candidate…”
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A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix by Seeherman, Howard J, Berasi, Stephen P, Brown, Christopher T, Martinez, Robert X, Juo, Z Sean, Jelinsky, Scott, Cain, Michael J, Grode, Jaclyn, Tumelty, Kathleen E, Bohner, Marc, Grinberg, Orly, Orr, Nadav, Shoseyov, Oded, Eyckmans, Jeroen, Chen, Christopher, Morales, Pablo R, Wilson, Christopher G, Vanderploeg, Eric J, Wozney, John M

“…Bone morphogenetic protein (BMP)/carriers approved for orthopedic procedures achieve efficacy superior or equivalent to autograft bone. However, required…”
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Genome-Resolved Meta-Omics Ties Microbial Dynamics to Process Performance in Biotechnology for Thiocyanate Degradation by Kantor, Rose S, Huddy, Robert J, Iyer, Ramsunder, Thomas, Brian C, Brown, Christopher T, Anantharaman, Karthik, Tringe, Susannah, Hettich, Robert L, Harrison, Susan T. L, Banfield, Jillian F

“…Remediation of industrial wastewater is important for preventing environmental contamination and enabling water reuse. Biological treatment for one industrial…”
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Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes by Aliaga Goltsman, Daniela S., Alexander, Lisa M., Lin, Jyun-Liang, Fregoso Ocampo, Rodrigo, Freeman, Benjamin, Lamothe, Rebecca C., Perez Rivas, Andres, Temoche-Diaz, Morayma M., Chadha, Shailaja, Nordenfelt, Natalie, Janson, Owen P., Barr, Ian, Devoto, Audra E., Cost, Gregory J., Butterfield, Cristina N., Thomas, Brian C., Brown, Christopher T.

“…Programmable, RNA-guided nucleases are diverse enzymes that have been repurposed for biotechnological applications. However, to further expand the therapeutic…”
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Combined analysis of microbial metagenomic and metatranscriptomic sequencing data to assess in situ physiological conditions in the premature infant gut by Sher, Yonatan, Olm, Matthew R, Raveh-Sadka, Tali, Brown, Christopher T, Sher, Ruth, Firek, Brian, Baker, Robyn, Morowitz, Michael J, Banfield, Jillian F

“…Microbes alter their transcriptomic profiles in response to the environment. The physiological conditions experienced by a microbial community can thus be…”
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Interactions between specific phytoplankton and bacteria affect lake bacterial community succession by Paver, Sara F., Hayek, Kevin R., Gano, Kelsey A., Fagen, Jennie R., Brown, Christopher T., Davis-Richardson, Austin G., Crabb, David B., Rosario-Passapera, Richard, Giongo, Adriana, Triplett, Eric W., Kent, Angela D.

“…Summary Time‐series observations and a phytoplankton manipulation experiment were combined to test the hypothesis that phytoplankton succession effects changes…”
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Hospitalized Premature Infants Are Colonized by Related Bacterial Strains with Distinct Proteomic Profiles by Brown, Christopher T, Xiong, Weili, Olm, Matthew R, Thomas, Brian C, Baker, Robyn, Firek, Brian, Morowitz, Michael J, Hettich, Robert L, Banfield, Jillian F

“…During the first weeks of life, microbial colonization of the gut impacts human immune system maturation and other developmental processes. In premature…”
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