Search Results - "BROWN, B. M."
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Multiple effects of physical activity on molecular and cognitive signs of brain aging: can exercise slow neurodegeneration and delay Alzheimer’s disease?
Published in Molecular psychiatry (01-08-2013)“…Western countries are experiencing aging populations and increased longevity; thus, the incidence of dementia and Alzheimer’s disease (AD) in these countries…”
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Heat Enhanced Follicular Delivery of Isotretinoin to the Skin
Published in Pharmaceutical research (01-08-2019)“…Purpose The aim of this work was to evaluate the use of short durations of externally applied heat with chemical penetration enhancers to improve delivery of…”
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3
Evaluating the effects of giraffe skin disease and wire snare wounds on the gaits of free-ranging Nubian giraffe
Published in Scientific reports (03-02-2023)“…Giraffe skin disease (GSD), a condition that results in superficial lesions in certain giraffe ( Giraffa spp.) populations, has emerged as a potential…”
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Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
Published in Molecular psychiatry (01-08-2013)“…Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to…”
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Multi-Domain Interventions for Dementia Prevention–A Systematic Review
Published in The Journal of nutrition, health & aging (01-12-2023)“…There is a growing incidence of cognitive decline and dementia associated with the ageing population. Lifestyle factors such as diet, physical activity, and…”
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Effects of triple antioxidant therapy on measures of cardiovascular autonomic neuropathy and on myocardial blood flow in type 1 diabetes: a randomised controlled trial
Published in Diabetologia (01-08-2013)“…Aims/hypothesis We evaluated the effects of a combination triple antioxidant therapy on measures of cardiovascular autonomic neuropathy (CAN) and myocardial…”
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Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin
Published in Journal of the European Academy of Dermatology and Venereology (01-05-2005)“…ABSTRACT Hyaluronic acid (HA) is a naturally occurring polyanionic, polysaccharide that consists of N‐acetyl‐d‐glucosamine and β‐glucoronic acid. It is present…”
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8
Standard errors and covariance matrices for smoothed rank estimators
Published in Biometrika (01-03-2005)“…A ‘pseudo-Bayesian’ interpretation of standard errors yields a natural induced smoothing of statistical estimating functions. When applied to rank estimation,…”
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Design, synthesis and characterization of linear unnatural amino acids for skin moisturization
Published in International journal of cosmetic science (01-02-2017)“…Objectives This work aimed to design, synthesize and characterize replacement natural moisturizing factor (NMF) composed of modified hygroscopic linear amino…”
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10
Localized Epidermal Drug Delivery Induced by Supramolecular Solvent Structuring
Published in Molecular pharmaceutics (04-01-2016)“…The preferential localization of drug molecules in the epidermis of human skin is considered advantageous for a number of agents, but achieving such a delivery…”
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11
Nail Swelling as a Pre-formulation Screen for the Selection and Optimisation of Ungual Penetration Enhancers
Published in Pharmaceutical research (01-12-2007)“…Targeting drug treatment to fungal infections that reside within or below the nail plate is problematic due to the highly restrictive barrier of the human…”
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Overcoming the nail barrier: A systematic investigation of ungual chemical penetration enhancement
Published in International journal of pharmaceutics (31-03-2009)“…This study investigated the in vitro nail permeability of penetrants of varying lipophilicity—caffeine (CF, log P −0.07), methylparaben (MP, log P 1.96) and…”
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13
Predation risk: a potential mechanism for effects of a wind energy facility on Greater Prairie‐Chicken survival
Published in Ecosphere (Washington, D.C) (01-06-2017)“…Recent expansion of the wind energy industry has raised concerns about the potential effects of wind energy facilities on prairie grouse. For example, efforts…”
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Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan
Published in Journal of controlled release (15-05-2000)“…Rapid mucociliary clearance of intranasally administered drugs is often a key factor in determining the bioavailability of such therapeutic agents. The use of…”
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A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy
Published in Diabetes care (01-11-1994)“…A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. E L Feldman , M J Stevens…”
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16
Fluctuating viability selection on morphology of cliff swallows is driven by climate
Published in Journal of evolutionary biology (01-05-2013)“…The extent to which fluctuating selection can maintain evolutionary stasis in most populations remains an unresolved question in evolutionary biology. Climate…”
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Triggered In Situ Drug Supersaturation and Hydrophilic Matrix Self-Assembly
Published in Pharmaceutical research (01-12-2012)“…ABSTRACT Purpose To understand in situ drug thermodynamic activity when embedded in a supramolecular structured hydrophilic matrix that simultaneously…”
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An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer
Published in International journal of colorectal disease (01-02-2012)“…Purpose There is growing enthusiasm for robotic-assisted laparoscopic operations across many surgical specialities, including colorectal surgery, often not…”
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Mechanistic insight into heat enhanced permeation of diclofenac and piroxicam in combination with chemical penetration enhancers across skin
Published in European journal of pharmaceutical sciences (01-12-2024)“…The topical application of heat offers considerable potential for enhancing the delivery of non-steroidal anti-inflammatory drugs across the skin barrier. A…”
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Discriminating the Molecular Identity and Function of Discrete Supramolecular Structures in Topical Pharmaceutical Formulations
Published in Molecular pharmaceutics (04-09-2012)“…There is a need to understand how solvent structuring influences drug presentation in pharmaceutical preparations, and the aim of this study was to…”
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