Search Results - "BROWN, Alan R"

Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa by Francis, Vanessa I., Waters, Elaine M., Finton-James, Sutharsan E., Gori, Andrea, Kadioglu, Aras, Brown, Alan R., Porter, Steven L.

“…Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-component systems (TCSs) comprising sensor kinases (SKs) and response…”
Get full text

Human FSH Glycoform α-Subunit Asparagine52 Glycans: Major Glycan Structural Consistency, Minor Glycan Variation in Abundance by Butnev, Viktor Y., May, Jeffrey V., Brown, Alan R., Sharma, Tarak, Butnev, Vladimir Y., White, William K., Harvey, David J., Bousfield, George R.

“…Follicle-stimulating hormone (FSH), an α/β heterodimeric glycoprotein hormone, consists of functionally significant variants resulting from the presence or…”
Get full text

Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei by McLean, Christopher J., Marles-Wright, Jon, Custodio, Rafael, Lowther, Jonathan, Kennedy, Amanda J., Pollock, Jacob, Clarke, David J., Brown, Alan R., Campopiano, Dominic J.

“…Sphingolipids (SLs) are ubiquitous elements in eukaryotic membranes and are also found in some bacterial and viral species. As well as playing an integral…”
Get full text

A Putative Gene Cluster for Aminoarabinose Biosynthesis Is Essential for Burkholderia cenocepacia Viability by ORTEGA, Ximena P, CARDONA, Silvia T, BROWN, Alan R, LOUTET, Slade A, FLANNAGAN, Ronald S, CAMPOPIANO, Dominic J, GOVAN, John R. W, VALVANO, Miguel A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Subdivision of the Bacterioferritin Comigratory Protein Family of Bacterial Peroxiredoxins Based on Catalytic Activity by Clarke, David J, Ortega, Ximena P, Mackay, C. Logan, Valvano, Miguel A, Govan, John R. W, Campopiano, Dominic J, Langridge-Smith, Pat, Brown, Alan R

“…Peroxiredoxins are ubiquitous proteins that catalyze the reduction of hydroperoxides, thus conferring resistance to oxidative stress. Using high-resolution…”
Get full text

Gene expression profiling of the preclinical scrapie-infected hippocampus by Brown, Alan R., Rebus, Selma, McKimmie, Clive S., Robertson, Kevin, Williams, Alun, Fazakerley, John K.

“…The molecular events that underlie prion disease neuropathology remain poorly defined. Within the hippocampus of the ME7/CV mouse scrapie model, profound CA1…”
Get full text

Culture-independent Multilocus sequence typing screening for Haemophilus influenzae cross-infection in non-cystic fibrosis bronchiectasis by Wilson, Catherine R, Mitchelmore, Philip J, Withers, Nicholas, Brown, Alan R

“…•H. influenzae strains can be identified from sputum using culture-independent MLST.•Culture-independent MLST can be used to screen for H. influenzae…”
Get full text

Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys by Hoivik, Debie J., Qualls, Charles W., Mirabile, Rosanna C., Cariello, Neal F., Kimbrough, Carie L., Colton, Heidi M., Anderson, Steven P., Santostefano, Michael J., Morgan, Ronda J. Ott, Dahl, Ray R., Brown, Alan R., Zhao, Zhiyang, Mudd, Paul N., Oliver, William B., Brown, H. Roger, Miller, Richard T.

“…There is little primate risk factor data in the literature evaluating the relationship between proposed mechanisms of PPAR agonist-induced hepatocarcinogenesis…”
Get full text

Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: enhanced transcription and PI3K and MAPK signaling by Hua, Guohua, George, Jitu W, Clark, Kendra L, Jonas, Kim C, Johnson, Gillian P, Southekal, Siddesh, Guda, Chittibabu, Hou, Xiaoying, Blum, Haley R, Eudy, James, Butnev, Viktor Y, Brown, Alan R, Katta, Sahithi, May, Jeffrey V, Bousfield, George R, Davis, John S

“…Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to…”
Get full text

Culture-independent multilocus sequence typing of Pseudomonas aeruginosa for cross-infection screening by Mitchelmore, Philip J., Withers, Nicholas J., Sheldon, Christopher D., Scotton, Chris J., Brown, Alan R.

“…•Preventing cross-infection with Pseudomonas aeruginosa is crucial within cystic fibrosis units.•We report a culture-independent approach to detecting shared…”
Get full text

Inducible cytokine gene expression in the brain in the ME7/CV mouse model of scrapie is highly restricted, is at a strikingly low level relative to the degree of gliosis and occurs only late in disease by Brown, Alan R, Webb, Jeanette, Rebus, Selma, Walker, Robert, Williams, Alun, Fazakerley, John K

“…1 Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK 2 Institute of Comparative Medicine, Department of Veterinary…”
Get full text

Characterization of secreted sphingosine‐1‐phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei by Custódio, Rafael, McLean, Christopher J., Scott, Andrew E., Lowther, Jonathan, Kennedy, Amanda, Clarke, David J., Campopiano, Dominic J., Sarkar‐Tyson, Mitali, Brown, Alan R.

“…Summary Sphingosine‐1‐phosphate (S1P), a bioactive sphingolipid metabolite, plays a critical role in the orchestration of immune responses. S1P levels within…”
Get full text

Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection by Govan, John R W, Brown, Alan R, Jones, Andrew M

“…The morbidity and mortality of patients with cystic fibrosis (CF) is primarily determined by chronic and debilitating lung infections caused by a surprisingly…”
Get more information

Mannitol promotes adherence of an outbreak strain of Burkholderia multivorans via an exopolysaccharide-independent mechanism that is associated with upregulation of newly identified fimbrial and afimbrial adhesins by Denman, Carmen C, Brown, Alan R

“…Burkholderia multivorans, a member of the Burkholderia cepacia complex (Bcc), is an important pathogen of the cystic fibrosis (CF) lung. Mannitol, approved as…”
Get full text

Growth on mannitol-rich media elicits a genome-wide transcriptional response in Burkholderia multivorans that impacts on multiple virulence traits in an exopolysaccharide-independent manner by Denman, Carmen C, Robinson, Matthew T, Sass, Andrea M, Mahenthiralingam, Eshwar, Brown, Alan R

“…In common with other members of the Burkholderia cepacia complex (BCC), Burkholderia multivorans is capable of producing exopolysaccharide (EPS) when grown on…”
Get full text

Paired Electrosynthesis at the Femtoliter Scale:  Formation of 9,10-Anthracenedione from the Oxidation of Anthracene and Reduction of Dioxygen by Amatore, Christian, Brown, Alan R

“…A system is described in which the unique properties of a pair of microband electrodes are exploited both to initiate and to probe the products of a paired…”
Get full text

Interrogating the Molecular Details of the Peroxiredoxin Activity of the Escherichia coli Bacterioferritin Comigratory Protein Using High-Resolution Mass Spectrometry by Clarke, David J, Mackay, C. Logan, Campopiano, Dominic J, Langridge-Smith, Pat, Brown, Alan R

“…Bacterioferritin comigratory protein (BCP) is a bacterial thioredoxin-dependent thiol peroxidase that reduces a variety of peroxide substrates. Using…”
Get full text

Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex by Bartholdson, S. Josefin, Brown, Alan R, Mewburn, Ben R, Clarke, David J, Fry, Stephen C, Campopiano, Dominic J, Govan, John R. W

“…1 School of Chemistry, University of Edinburgh, Edinburgh EH9 3JJ, UK 2 Centre for Infectious Diseases, University of Edinburgh, Edinburgh EH16 4SB, UK 3…”
Get full text

Structural and Voltammetric Studies on the Reduction of the Bis(2,2‘-bipyridyl)platinum(II) Cation in Aprotic Media by Brown, Alan R, Guo, Zijian, Mosselmans, Fred W. J, Parsons, Simon, Schröder, Martin, Yellowlees, Lesley J

“…The reduction of the bis(2,2‘-bipyridyl)platinum(II) cation, [Pt(bpy)2]2+, in aprotic media has been studied electrochemically. Voltammetry at scan rates above…”
Get full text

Geometry's Giant Leap by Brown, Alan R.

“…Introduces a project in which students use dynamic geometry software with a TI-92 graphing calculator to study geometric constructions. Concludes that…”
Get full text