Search Results - "BROUWER, Margreet"

Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire by Dimova, Tanya, Brouwer, Margreet, Gosselin, Françoise, Tassignon, Joël, Leo, Oberdan, Donner, Catherine, Marchant, Arnaud, Vermijlen, David

“…Significance Despite their enormous potential for diversity (in excess of 10 ¹⁵ theoretical receptor specificities), the human γδ T-cell repertoire is…”
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IL-23R and TCR signaling drives the generation of neonatal Vγ9Vδ2 T cells expressing high levels of cytotoxic mediators and producing IFN-γ and IL-17 by Moens, Emmanuelle, Brouwer, Margreet, Dimova, Tanya, Goldman, Michel, Willems, Fabienne, Vermijlen, David

“…IL‐23, highly produced by neonatal DC, promotes the generation of neonatal Vγ9Vδ2 T cells expressing a range of cytotoxic mediators and producing IFN‐γ and…”
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Real-time PCR for detection and quantification of fungal and oomycete tomato pathogens in plant and soil samples by Lievens, Bart, Brouwer, Margreet, Vanachter, Alfons C.R.C., Cammue, Bruno P.A., Thomma, Bart P.H.J.

“…Although new, rapid detection and identification technologies are becoming available more and more for various plant pathogens, pathogen quantification remains…”
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Quantitative assessment of phytopathogenic fungi in various substrates using a DNA macroarray by Lievens, Bart, Brouwer, Margreet, Vanachter, Alfons C. R. C., Lévesque, C. André, Cammue, Bruno P. A., Thomma, Bart P. H. J.

“…Summary Detection, identification and quantification of plant pathogens are the cornerstones of preventive plant disease  management.  To  detect  multiple …”
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Study of the Role of Antimicrobial Glucosinolate-Derived Isothiocyanates in Resistance of Arabidopsis to Microbial Pathogens by Koenraad F. M.-J. Tierens, Bart P. H. J. Thomma, Brouwer, Margreet, Schmidt, Jürgen, Katherine Kistner, Andrea Porzel, Mauch-Mani, Brigitte, Bruno P. A. Cammue, Broekaert, Willem F.

“…Crude aqueous extracts from Arabidopsis leaves were subjected to chromatographic separations, after which the different fractions were monitored for…”
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In vivo HIV-1 Infection of CD45RA+CD4+T Cells Is Established Primarily by Syncytium-Inducing Variants and Correlates with the Rate of CD4+T Cell Decline by Blaak, Hetty, Angelique B. van't Wout, Brouwer, Margreet, Hooibrink, Berend, Hovenkamp, Egbert, Schuitemaker, Hanneke

“…Switch from non-syncytium-inducing (NSI) to syncytium-inducing (SI) HIV type 1 (HIV-1) is associated with accelerated CD4+T cell depletion, which might…”
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Design and development of a DNA array for rapid detection and identification of multiple tomato vascular wilt pathogens by Lievens, Bart, Brouwer, Margreet, Vanachter, Alfons C.R.C., Lévesque, C.André, Cammue, Bruno P.A., Thomma, Bart P.H.J.

“…Fusarium wilt, caused by Fusarium oxysporum f. sp. lycopersici, and Verticillium wilt, caused by either Verticillium albo-atrum or Verticillium dahliae, are…”
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Phenotypic and Genotypic Comparisons of CCR5- and CXCR4-Tropic Human Immunodeficiency Virus Type 1 Biological Clones Isolated from Subtype C-Infected Individuals by POLLAKIS, Georgios, ABEBE, Almaz, KLIPHUIS, Aletta, CHALABY, Moustapha I. M, BAKKER, Margreet, MENGISTU, Yohannes, BROUWER, Margreet, GOUDSMIT, Jaap, SCHUITEMAKER, Hanneke, PAXTON, William A

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Effector V gamma 9V delta 2 T cells dominate the human fetal gamma delta T-cell repertoire by Dimova, Tanya, Brouwer, Margreet, Gosselin, Francoise, Tassignon, Joeel, Leo, Oberdan, Donner, Catherine, Marchant, Arnaud, Vermijlen, David

“…gamma delta T cells are unconventional T cells recognizing antigens via their gamma delta T-cell receptor (TCR) in a way that is fundamentally different from…”
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Evolution of Syncytium-Inducing and Non-Syncytium-Inducing Biological Virus Clones in Relation to Replication Kinetics during the Course of Human Immunodeficiency Virus Type 1 Infection by van 't Wout, A B, Blaak, H, Ran, L J, Brouwer, M, Kuiken, C, Schuitemaker, H

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In Vitro Replication Kinetics of Human Immunodeficiency Virus Type 1 (HIV-1) Variants in Relation to Virus Load in Long-Term Survivors of HIV-1 Infection by Blaak, Hetty, Brouwer, Margreet, Ran, Leonie J., de Wolf, Frank, Schuitemaker, Hanneke

“…In 7 long-term survivors (LTS) and 8 progressors, all carrying solely non-syncytium-inducing variants, a possible correlation between in vitro virus…”
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Human cytomegalovirus elicits fetal γδ T cell responses in utero by Vermijlen, David, Brouwer, Margreet, Donner, Catherine, Liesnard, Corinne, Tackoen, Marie, Van Rysselberge, Michel, Twité, Nicolas, Goldman, Michel, Marchant, Arnaud, Willems, Fabienne

“…The fetus and infant are highly susceptible to viral infections. Several viruses, including human cytomegalovirus (CMV), cause more severe disease in early…”
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Abstract 4154: EOS100850 inhibits A2A receptor signaling in human whole blood: Two pharmacodynamic assays to monitor EOS100850 activity in clinical studies by Martinoli, Chiara, Brouwer, Margreet, Houthuys, Erica, Mercier, Marjorie, Wald, Noemie, Gomes, Bruno, Crosignani, Stefano, Bodo, Veronique

“…Abstract High levels of extracellular adenosine in the tumor microenvironment promote tumor immune evasion. We and others have shown that adenosine,…”
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Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies by Preillon, Julie, Cuende, Julia, Rabolli, Virginie, Garnero, Lucile, Mercier, Marjorie, Wald, Noémie, Pappalardo, Angela, Denies, Sofie, Jamart, Diane, Michaux, Anne-Catherine, Pirson, Romain, Pitard, Vincent, Bagot, Martine, Prasad, Shruthi, Houthuys, Erica, Brouwer, Margreet, Marillier, Reece, Lambolez, Florence, Marchante, Joäo R, Nyawouame, Florence, Carter, Mathew J, Baron-Bodo, Véronique, Marie-Cardine, Anne, Cragg, Mark, Déchanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

“…TIGIT is an immune checkpoint inhibitor expressed by effector CD4 and CD8 T cells, NK cells, and regulatory T cells (Tregs). Inhibition of TIGIT-ligand binding…”
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Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humans by Burny, Wivine, Marchant, Arnaud, Hervé, Caroline, Callegaro, Andrea, Caubet, Magalie, Fissette, Laurence, Gheyle, Lien, Legrand, Catherine, Ndour, Cheikh, Tavares Da Silva, Fernanda, van der Most, Robbert, Willems, Fabienne, Didierlaurent, Arnaud M, Yarzabal, Juan

“…Highlights•Reactogenicity and inflammatory markers evaluated after HBsAg-adjuvanted vaccines. •Significant associations between systemic symptoms and IL-6 and…”
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Abstract 3261: EOS100850, a non-brain penetrant highly selective A2Areceptor antagonist, uniquely maintains high potency within the adenosine rich tumor microenvironment by Houthuys, Erica, Basilico, Paola, Brouwer, Margreet, Deregnaucourt, Theo, Detheux, Michel, Driessens, Gregory, Gomes, Bruno, Leroy, Xavier, Marchante, Joao, Marillier, Reece, Swiercz, Jakub, Crosignani, Stefano

“…Abstract High levels of extracellular adenosine in the tumor microenvironment promote tumor immune evasion. We and others have shown that adenosine,…”
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Abstract 4969: TIGIT pathway phenotyping sheds light on promising strategies to restore anti-tumor immunity by Wald, Noémie, Mercier, Marjorie, Cuende, Julia, Nyawouame, Florence, Prasad, Shruthi, Brouwer, Margreet, Houthuys, Erica, Marie-Cardine, Anne, Bagot, Martine, Driessens, Grégory, Bodo, Véronique, Hoofd, Catherine

“…Abstract TIGIT is a T cell co-inhibitory receptor recently described as a key checkpoint driving tumor cell immunosuppression. It is predominantly expressed on…”
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Infectious Cellular Load in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals and Susceptibility of Peripheral Blood Mononuclear Cells from Their Exposed Partners to Non-Syncytium-Inducing HIV-1 as Major Determinants for HIV-1 Transmission in Homosexual Couples by Blaak, H, van't Wout, A B, Brouwer, M, Cornelissen, M, Kootstra, N A, Albrecht-van Lent, N, Keet, R P, Goudsmit, J, Coutinho, R A, Schuitemaker, H

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Abstract 3278: EOS100850 potently restores adenosine A2Areceptor-dependent suppression of T cell function in the adenosine rich tumor microenvironment by Houthuys, Erica, Basilico, Paola, Bodo, Veronique, Brouwer, Margreet, Detheux, Michel, Driessens, Gregory, Gomes, Bruno, Hermant, Annelise, Hoofd, Catherine, Lambolez, Florence, Leroy, Xavier, Marillier, Reece, Martinoli, Chiara, Mercier, Marjorie, Nyawouame, Florence, Prasad, Shruthi, Scoumanne, Ariane, Crosignani, Stefano

“…Abstract Adenosine is a potent immunosuppressive metabolite that is often found elevated in the extracellular tumor microenvironment (TME). We determined…”
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Effector V[gamma]9V[delta]2 T cells dominate the human fetal [gamma][delta] T-cell repertoire by Dimova, Tanya, Brouwer, Margreet, Gosselin, Françoise, Tassignon, Joël, Leo, Oberdan, Donner, Catherine, Marchant, Arnaud, Vermijlen, David

“…γδ T cells are unconventional T cells recognizing antigens via their γδ T-cell receptor (TCR) in a way that is fundamentally different from conventional αβ T…”
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