Search Results - "BROUCKAERT, Peter"

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors by Alexander, Stephen PH, Fabbro, Doriano, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Beuve, Annie, Brouckaert, Peter, Bryant, Clare, Burnett, John C., Farndale, Richard W., Friebe, Andreas, Garthwaite, John, Hobbs, Adrian J., Jarvis, Gavin E., Kuhn, Michaela, MacEwan, David, Monie, Tom P., Papapetropoulos, Andreas, Potter, Lincoln R., Schmidt, Harald H.H.W., Szabo, Csaba, Waldman, Scott A.

“…The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
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Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway by Bibli, Sofia-Iris, Andreadou, Ioanna, Chatzianastasiou, Athanasia, Tzimas, Christos, Sanoudou, Despina, Kranias, Evangelia, Brouckaert, Peter, Coletta, Ciro, Szabo, Csaba, Kremastinos, Dimitrios Th, Iliodromitis, Efstathios K, Papapetropoulos, Andreas

“…H2S is known to confer cardioprotection; however, the pathways mediating its effects in vivo remain incompletely understood. The purpose of the present study…”
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Of mice, men, and inflammation by Cauwels, Anje, Vandendriessche, Benjamin, Brouckaert, Peter

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Loss of α1β1 Soluble Guanylate Cyclase, the Major Nitric Oxide Receptor, Leads to Moyamoya and Achalasia by Hervé, Dominique, Philippi, Anne, Belbouab, Reda, Zerah, Michel, Chabrier, Stéphane, Collardeau-Frachon, Sophie, Bergametti, Francoise, Essongue, Aurore, Berrou, Eliane, Krivosic, Valérie, Sainte-Rose, Christian, Houdart, Emmanuel, Adam, Frédéric, Billiemaz, Kareen, Lebret, Marilyne, Roman, Sabine, Passemard, Sandrine, Boulday, Gwenola, Delaforge, Audrey, Guey, Stéphanie, Dray, Xavier, Chabriat, Hugues, Brouckaert, Peter, Bryckaert, Maryjke, Tournier-Lasserve, Elisabeth

“…Moyamoya is a cerebrovascular condition characterized by a progressive stenosis of the terminal part of the internal carotid arteries (ICAs) and the…”
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Ferulic acid-4-O-sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice by Van Rymenant, Evelien, Van Camp, John, Pauwels, Bart, Boydens, Charlotte, Vanden Daele, Laura, Beerens, Katrijn, Brouckaert, Peter, Smagghe, Guy, Kerimi, Asimina, Williamson, Gary, Grootaert, Charlotte, Van de Voorde, Johan

“…Consumption of foods rich in ferulic acid (FA) such as wholegrain cereals, or FA precursors such as chlorogenic acids in coffee, is inversely correlated with…”
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Safe eradication of large established tumors using neovasculature‐targeted tumor necrosis factor‐based therapies by Huyghe, Leander, Van Parys, Alexander, Cauwels, Anje, Van Lint, Sandra, De Munter, Stijn, Bultinck, Jennyfer, Zabeau, Lennart, Hostens, Jeroen, Goethals, An, Vanderroost, Nele, Verhee, Annick, Uzé, Gilles, Kley, Niko, Peelman, Frank, Vandekerckhove, Bart, Brouckaert, Peter, Tavernier, Jan

“…Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines…”
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Inhaled Nitric Oxide Improves Outcomes After Successful Cardiopulmonary Resuscitation in Mice by MINAMISHIMA, Shizuka, KIDA, Kotaro, LIU, Christina H, BLOCH, Kenneth D, ICHINOSE, Fumito, TOKUDA, Kentaro, HUIFANG WANG, SIPS, Patrick Y, KOSUGI, Shizuko, MANDEVILLE, Joseph B, BUYS, Emmanuel S, BROUCKAERT, Peter, LIU, Philip K

“…Sudden cardiac arrest (CA) is a leading cause of death worldwide. Breathing nitric oxide (NO) reduces ischemia/reperfusion injury in animal models and in…”
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Microcirculatory Function during Endotoxemia-A Functional Citrulline-Arginine-NO Pathway and NOS3 Complex Is Essential to Maintain the Microcirculation by Wijnands, Karolina A P, Meesters, Dennis M, Vandendriessche, Benjamin, Briedé, Jacob J, van Eijk, Hans M H, Brouckaert, Peter, Cauwels, Anje, Lamers, Wouter H, Poeze, Martijn

“…Competition for the amino acid arginine by endothelial nitric-oxide synthase (NOS3) and (pro-)inflammatory NO-synthase (NOS2) during endotoxemia appears…”
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ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade by Silence, Karen, Dreier, Torsten, Moshir, Mahan, Ulrichts, Peter, Gabriels, Sofie ME, Saunders, Michael, Wajant, Harald, Brouckaert, Peter, Huyghe, Leander, Van Hauwermeiren, Tim, Thibault, Alain, De Haard, Hans J

“…Overexpression of CD70 has been documented in a variety of solid and hematological tumors, where it is thought to play a role in tumor proliferation and…”
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Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice by Clerte, Maëva, MD, Baron, David M., MD, Brouckaert, Peter, MD, PhD, Ernande, Laura, MD, PhD, Raher, Michael J., BS, Flynn, Aidan W., MD, PhD, Picard, Michael H., MD, Bloch, Kenneth D., MD, Buys, Emmanuel S., PhD, Scherrer-Crosbie, Marielle, MD, PhD

“…Background When activated by the sympathetic nervous system, brown adipose tissue (BAT) increases energy expenditure to produce heat. Augmenting BAT mass or…”
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The Role of Soluble Guanylyl Cyclase in Chronic Obstructive Pulmonary Disease by GLYNOS, Constantinos, DUPONT, Lisa L, VASSILAKOPOULOS, Theodoros, PAPAPETROPOULOS, Andreas, BROUCKAERT, Peter, GIANNIS, Athanassios, JOOS, Guy F, BRACKE, Ken R, BRUSSELLE, Guy G

“…Soluble guanylyl cyclase (sGC), a cyclic guanosine 5'-monophosphate-generating enzyme, regulates smooth muscle tone and exerts antiinflammatory effects in…”
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Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice by Hobai, Ion A, Aziz, Kanwal, Buys, Emmanuel S, Brouckaert, Peter, Siwik, Deborah A, Colucci, Wilson S

“…ABSTRACTIn male mice, sepsis-induced cardiomyopathy develops as a result of dysregulation of myocardial calcium (Ca) handling, leading to depressed cellular Ca…”
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Gender-specific hypertension and responsiveness to nitric oxide in sGCα1 knockout mice by Buys, Emmanuel S., Sips, Patrick, Vermeersch, Pieter, Raher, Michael J., Rogge, Elke, Ichinose, Fumito, Dewerchin, Mieke, Bloch, Kenneth D., Janssens, Stefan, Brouckaert, Peter

“…Aim The effects of nitric oxide (NO) in the cardiovascular system are attributed in part to cGMP synthesis by the α1β1 isoform of soluble guanylate cyclase…”
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Transcriptome analysis in patients with chronic kidney disease on hemodialysis disclosing a key role for CD16+CX3CR1+ monocytes by Schepers, Eva, Houthuys, Erica, Dhondt, Annemieke, De Meyer, Grim, Neirynck, Nathalie, Bernaert, Pascale, Van den Bergh, Rafael, Brouckaert, Peter, Vanholder, Raymond, Glorieux, Griet

“…The risk for cardiovascular morbidity and mortality is increased in chronic kidney disease; in this process micro-inflammation plays an essential role…”
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Newly Identified NO‐Sensor Guanylyl Cyclase/Connexin 43 Association Is Involved in Cardiac Electrical Function by Crassous, Pierre‐Antoine, Shu, Ping, Huang, Can, Gordan, Richard, Brouckaert, Peter, Lampe, Paul D., Xie, Lai‐Hua, Beuve, Annie

“…Background Guanylyl cyclase, a heme‐containing α1β1 heterodimer (GC1), produces cGMP in response to Nitric oxide (NO) stimulation. The NO‐GC1‐cGMP pathway…”
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Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2 by Cauwels, Anje, Janssen, Ben, Waeytens, Anouk, Cuvelier, Claude, Brouckaert, Peter

“…Dysregulated apoptotic cell death contributes to many pathological conditions, including sepsis, prompting the suggestion that caspase inhibition to block…”
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Soluble guanylate cyclase α1-deficient mice: a novel murine model for primary open angle glaucoma by Buys, Emmanuel S, Ko, Yu-Chieh, Alt, Clemens, Hayton, Sarah R, Jones, Alexander, Tainsh, Laurel T, Ren, Ruiyi, Giani, Andrea, Clerté, Maeva, Abernathy, Emma, Tainsh, Robert E T, Oh, Dong-Jin, Malhotra, Rajeev, Arora, Pankaj, de Waard, Nadine, Yu, Binglan, Turcotte, Raphael, Nathan, Daniel, Scherrer-Crosbie, Marielle, Loomis, Stephanie J, Kang, Jae H, Lin, Charles P, Gong, Haiyan, Rhee, Douglas J, Brouckaert, Peter, Wiggs, Janey L, Gregory, Meredith S, Pasquale, Louis R, Bloch, Kenneth D, Ksander, Bruce R

“…Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown…”
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The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems by Vandendriessche, Benjamin, Rogge, Elke, Goossens, Vera, Vandenabeele, Peter, Stasch, Johannes-Peter, Brouckaert, Peter, Cauwels, Anje

“…Sepsis and septic shock are associated with high mortality rates and the majority of sepsis patients die due to complications of multiple organ failure (MOF)…”
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Critical role for small and large conductance calcium-dependent potassium channels in endotoxemia and TNF toxicity by Cauwels, Anje, Brouckaert, Peter

“…Sepsis-associated vasodilation and shock are centrally orchestrated by NO. Nevertheless, inhibition of NO synthesis may not be the target of choice for the…”
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Toll-like Receptor 4 Signaling Confers Cardiac Protection against Ischemic Injury via Inducible Nitric Oxide Synthase- and Soluble Guanylate Cyclase-dependent Mechanisms by WANG, E, YAN FENG, MING ZHANG, LIN ZOU, YAN LI, BUYS, Emmanuel S, PEIGEN HUANG, BROUCKAERT, Peter, WEI CHAO

“…Prior administration of a small dose of lipopolysaccharide confers a cardiac protection against ischemia-reperfusion injury. However, the signaling mechanisms…”
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