Search Results - "BROOKS, Simon P"

Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model by Harrison, David J., Busse, Monica, Openshaw, Rebecca, Rosser, Anne E., Dunnett, Stephen B., Brooks, Simon P.

“…Huntington's disease (HD) is a neurodegenerative disease caused by a mutation within the huntingtin gene that induces degeneration within the striatal nuclei,…”
Get full text

Comparison of mHTT Antibodies in Huntington's Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development by Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen B, Brooks, Simon P

“…Huntington's disease (HD) cellular pathology is characterised by the aggregation of mutant huntingtin (mHTT) protein into inclusion bodies. The present paper…”
Get full text

CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease by Fjodorova, Marija, Louessard, Morgane, Li, Zongze, De La Fuente, Daniel C., Dyke, Emma, Brooks, Simon P., Perrier, Anselme L., Li, Meng

“…The mechanisms underlying the selective degeneration of medium spiny neurons (MSNs) in Huntington disease (HD) remain largely unknown. CTIP2, a transcription…”
Get full text

A Longitudinal Operant Assessment of Cognitive and Behavioural Changes in the HdhQ111 Mouse Model of Huntington's Disease by Yhnell, Emma, Dunnett, Stephen B, Brooks, Simon P

“…Huntington's disease (HD) is characterised by motor symptoms which are often preceded by cognitive and behavioural changes, that can significantly contribute…”
Get full text

Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD by Bowles, Kathryn R, Brooks, Simon P, Dunnett, Stephen B, Jones, Lesley

“…Huntington's disease is a neurodegenerative disorder characterised primarily by motor abnormalities, and is caused by an expanded polyglutamine repeat in the…”
Get full text

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice by Muha, Villo, Williamson, Ritchie, Hills, Rachel, McNeilly, Alison D, McWilliams, Thomas G, Alonso, Jana, Schimpl, Marianne, Leney, Aneika C, Heck, Albert J R, Sutherland, Calum, Read, Kevin D, McCrimmon, Rory J, Brooks, Simon P, van Aalten, Daan M F

“…O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However,…”
Get full text

The Effect of Tissue Preparation and Donor Age on Striatal Graft Morphology in the Mouse by Harrison, David J., Roberton, Victoria H., Vinh, Ngoc-Nga, Brooks, Simon P., Dunnett, Stephen B., Rosser, Anne E.

“…Huntington's disease (HD) is a progressive neurodegenerative disease in which striatal medium spiny neurons (MSNs) are lost. Neuronal replacement therapies aim…”
Get full text

Correction: Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD by Bowles, Kathryn R, Brooks, Simon P, Hughes, Alis C, Dunnett, Stephen B, Jones, Lesley

“…[This corrects the article DOI: 10.1371/journal.pone.0144864.]…”
Get full text

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand by McWilliams, Thomas G., Prescott, Alan R., Montava-Garriga, Lambert, Ball, Graeme, Singh, François, Barini, Erica, Muqit, Miratul M.K., Brooks, Simon P., Ganley, Ian G.

“…Dysregulated mitophagy has been linked to Parkinson's disease (PD) due to the role of PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced…”
Get full text

X-linked cataract and Nance-Horan syndrome are allelic disorders by Coccia, Margherita, Brooks, Simon P., Webb, Tom R., Christodoulou, Katja, Wozniak, Izabella O., Murday, Victoria, Balicki, Martha, Yee, Harris A., Wangensteen, Teresia, Riise, Ruth, Saggar, Anand K., Park, Soo-Mi, Kanuga, Naheed, Francis, Peter J., Maher, Eamonn R., Moore, Anthony T., Russell-Eggitt, Isabelle M., Hardcastle, Alison J.

“…Nance-Horan syndrome (NHS) is an X-linked developmental disorder characterized by congenital cataract, dental anomalies, facial dysmorphism and, in some cases,…”
Get full text

Motor Assessment in Huntington's Disease Mice by Dunnett, Stephen B, Brooks, Simon P

“…Motor deficits are a characteristic consequence of striatal damage, whether induced by experimental lesions, or in genetic models of Huntington's disease…”
Get more information

The utilisation of operant delayed matching and non-matching to position for probing cognitive flexibility and working memory in mouse models of Huntington's disease by Yhnell, Emma, Dunnett, Stephen B., Brooks, Simon P.

“…•We compared delayed matching and non-matching to position (DMTP and DNMTP) tasks in two different operant apparatus, the 9-hole operant apparatus…”
Get full text

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease by Bayram-Weston, Zubeyde, Olsen, Elliott, Harrison, David J., Dunnett, Stephen B., Brooks, Simon P.

“…•A modified reliable Golgi–Cox method is described.•It is inexpensive and can be performed in any neuroscience lab.•Perfusion–fixation with 4% paraformaldehyde…”
Get full text

Tests to assess motor phenotype in mice: a user's guide by Brooks, Simon P, Dunnett, Stephen B

“…Key Points The identification of motor abnormalities in mouse models of disease is dependent on the choice of an appropriate behavioural test(s). The utility…”
Get full text

Cognitive training modifies disease symptoms in a mouse model of Huntington's disease by Yhnell, Emma, Lelos, Mariah J., Dunnett, Stephen B., Brooks, Simon P.

“…Huntington's disease (HD) is an incurable neurodegenerative disorder which causes a triad of motor, cognitive and psychiatric disturbances. Cognitive…”
Get full text

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo by McWilliams, Thomas G, Barini, Erica, Pohjolan-Pirhonen, Risto, Brooks, Simon P, Singh, François, Burel, Sophie, Balk, Kristin, Kumar, Atul, Montava-Garriga, Lambert, Prescott, Alan R, Hassoun, Sidi Mohamed, Mouton-Liger, François, Ball, Graeme, Hills, Rachel, Knebel, Axel, Ulusoy, Ayse, Di Monte, Donato A, Tamjar, Jevgenia, Antico, Odetta, Fears, Kyle, Smith, Laura, Brambilla, Riccardo, Palin, Eino, Valori, Miko, Eerola-Rautio, Johanna, Tienari, Pentti, Corti, Olga, Dunnett, Stephen B, Ganley, Ian G, Suomalainen, Anu, Muqit, Miratul M K

“…Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture and studies have elaborated the PINK1-dependent regulation…”
Get full text

Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease by Brooks, Simon P, Jones, Lesley, Dunnett, Stephen B

“…Highlights ► The rationale for the longitudinal HD mouse characterisation is described. ► Longitudinal behavioural, genetic and neuropathological methods are…”
Get full text

Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice by Brooks, Simon P, Janghra, Nari, Workman, Victoria L, Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen B

“…Highlights ► The authors sought to longitudinally characterise the nature, severity and development of behavioural abnormalities in the R6/1 (C57BL/6J) mouse…”
Get full text

Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice by Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen B, Brooks, Simon P

“…Highlights ► Characterization of disease neuropathology in the (C57BL/6J) YAC128 mouse line. ► The YAC128 mice showed a greater density of aggregates in the…”
Get full text

Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice by Bayram-Weston, Zubeyde, Jones, Lesley, Dunnett, Stephen B, Brooks, Simon P

“…Highlights ► The study aimed to characterize anatomically the disease progression in the R6/1 mouse line using S830 and GFAP immunohistochemistry, stereology…”
Get full text