Search Results - "BRONAUGH, R. L"

In vitro human skin penetration of diethanolamine by Kraeling, M.E.K, Yourick, J.J, Bronaugh, R.L

“…Concerns about the safety of diethanolamine (DEA) have been raised by the National Toxicology Program (NTP). Therefore, we measured the extent of DEA…”
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Assessment of skin absorption and irritation potential of arachidonic acid and glyceryl arachidonate using in vitro diffusion cell techniques by Eppler, A.R., Kraeling, M.E.K., Wickett, R.R., Bronaugh, R.L.

“…Arachidonic acid (AA), a precursor of pro-inflammatory mediators, and its glycerin ester, glyceryl arachidonate (GA), are reportedly used in cosmetic products…”
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Percutaneous Absorption and Metabolism of Coumarin in Human and Rat Skin by Yourick, Jeffrey J., Bronaugh, Robert L.

“…Coumarin is widely used as a fragrance in cosmetics, perfumes and soaps. The Food and Drug Administration banned coumarin use in food because of reports that…”
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The Effects of an Alpha Hydroxy Acid (Glycolic Acid) on Hairless Guinea Pig Skin Permeability by Hood, H.L, Kraeling, M.E.K, Robl, M.G, Bronaugh, R.L

“…The barrier integrity of hairless guinea pig skin after treatment with an alpha hydroxy acid was assessed through in vivo topical application of an…”
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Percutaneous Penetration and Metabolism of 2-Nitro-p-phenylenediamine in Human and Fuzzy Rat Skin by Yourick, Jeffrey J., Bronaugh, Robert L.

“…2-Nitro-p-phenylenediamine (2NPPD) is a dye used in semipermanent and permanent (tinting color) hair dye formulations. National Toxicology Program toxicology…”
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In vitro and in vivo percutaneous absorption of catechol by Jung, C.T, Wickett, R.R, Desai, P.B, Bronaugh, R.L

“…The Cosmetic Ingredient Review Expert Panel found insufficient data to conclude that catechol could be used safely in permanent hair dye products. Information…”
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In vitro percutaneous absorption of the fragrance ingredient musk xylol by Hood, H.L., Wickett, R.R., Bronaugh, R.L.

“…The percutaneous absorption of the fragrance fixative musk xylol was measured in vitro in human and hairless guinea pig skin. For comparison, musk xylol was…”
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Characterization of esterase and alcohol dehydrogenase activity in skin. Metabolism of retinyl palmitate to retinol (vitamin A) during percutaneous absorption by BOEHNLEIN, J, SAKR, A, LICHTIN, J. L, BRONAUGH, R. L

“…Retinyl palmitate, a widely used ingredient in cosmetic products, is promoted for its beneficial effects on the appearance of skin. Previous studies suggest…”
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Maintenance of skin viability during in vitro percutaneous absorption/metabolism studies by Collier, S W, Sheikh, N M, Sakr, A, Lichtin, J L, Stewart, R F, Bronaugh, R L

“…The assessment of cutaneous metabolism during in vitro percutaneous absorption studies requires maintenance of the viability of the skin section. With the use…”
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Percutaneous absorption and metabolism of pyrene, benzo[a]pyrene, and di(2-ethylhexyl) phthalate: comparison of in vitro and in vivo results in the hairless guinea pig by Ng, K M, Chu, I, Bronaugh, R L, Franklin, C A, Somers, D A

“…The in vitro and in vivo absorption and metabolism of pyrene, benzo[a]pyrene, and di(2-ethylhexyl) phthalate (DEHP) were investigated in the hairless guinea…”
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Methods for in vitro percutaneous absorption studies IV: The flow-through diffusion cell by Bronaugh, R L, Stewart, R F

“…A flow-through diffusion cell system for percutaneous absorption studies has been developed. The results of initial studies with a limited number of compounds…”
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Influence of Metabolism in Skin on Dosimetry after Topical Exposure by Bronaugh, R L, Collier, S W, Macpherson, S E, Kraeling, M E

“…Metabolism of chemicals occurs in skin and therefore should be taken into account when one determines topical exposure dose. Skin metabolism is difficult to…”
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In vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans by Bronaugh, R L, Wester, R C, Bucks, D, Maibach, H I, Sarason, R

“…The percutaneous absorption of the fragrance diethyl maleate was measured in vivo in human and monkey studies. With the application sites occluded, 54% of the…”
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Dose-response relationship in skin sensitization by Bronaugh, R L, Roberts, C D, McCoy, J L

“…The dose-response relationship (challenge phase) of the skin sensitization response was investigated in previously sensitized Hartley guinea pigs. Larger…”
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Vehicle effects on percutaneous absorption: in vivo and in vitro comparisons with human skin by Bronaugh, R L, Franz, T J

“…The percutaneous absorption of benzoic acid, caffeine and testosterone through human skin was measured by using in vivo and in vitro techniques. The compounds…”
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Extent of cutaneous metabolism during percutaneous absorption of xenobiotics by Bronaugh, R L, Stewart, R F, Storm, J E

“…In vitro percutaneous absorption studies generally do not determine whether biotransformation occurs during passage of a substance through the skin. Since it…”
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Fate of chemicals in skin after dermal application: does the in vitro skin reservoir affect the estimate of systemic absorption? by Yourick, Jeffrey J, Koenig, Michael L, Yourick, Debra L, Bronaugh, Robert L

“…Recent international guidelines for the conduct of in vitro skin absorption studies put forward different approaches for addressing the status of chemicals…”
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Use of in vitro skin penetration data and a physiologically based model to predict in vivo blood levels of benzoic acid by MACPHERSON, S. E, BARTON, C. N, BRONAUGH, R. L

“…A physiologically based pharmacokinetic (PB PK) model was developed to predict plasma levels of benzoic acid (BA) in the hairless guinea pig after topical…”
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Percutaneous absorption of trinitrobenzene: animal models for human skin by Kraeling, Margaret E. K., Reddy, Gunda, Bronaugh, Robert L.

“…The percutaneous absorption of 1,3,5‐trinitrobenzene (TNB) was studied in viable skin from hairless guinea pigs (HGP), Fischer 344 rats and humans. Skin was…”
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In vitro skin absorption and metabolism of benzoic acid, p-aminobenzoic acid, and benzocaine in the hairless guinea pig by NATHAN, D, SAKR, A, LICHTIN, J. L, BRONAUGH, R. L

“…The percutaneous absorption and metabolism of three structurally related compounds, benzoic acid, p-aminobenzoic acid (PABA), and ethyl aminobenzoate…”
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