Search Results - "BROMFIELD, John J"

A role for seminal plasma in modulating pregnancy outcomes in domestic species by Bromfield, John J

“…Seminal plasma is a complex fluid produced by the accessory glands of the male reproductive tract. Seminal plasma acts primarily as a transport medium for…”
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Tolerance and Innate Immunity Shape the Development of Postpartum Uterine Disease and the Impact of Endometritis in Dairy Cattle by Sheldon, I. Martin, Cronin, James G, Bromfield, John J

“…Bacteria are ubiquitous in the bovine uterus after parturition, but 50 years ago, cows tolerated these bacteria and few animals developed uterine disease. Now,…”
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Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring by Bromfield, John J., Schjenken, John E., Chin, Peck Y., Care, Alison S., Jasper, Melinda J., Robertson, Sarah A.

“…Paternal characteristics and exposures influence physiology and disease risks in progeny, but the mechanisms are mostly unknown. Seminal fluid, which affects…”
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Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro by Bromfield, John J, Sheldon, I. Martin

“…Infections of the reproductive tract or mammary gland with Gram-negative bacteria perturb ovarian function, follicular growth, and fecundity in cattle. We…”
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Specific Strains of Escherichia coli Are Pathogenic for the Endometrium of Cattle and Cause Pelvic Inflammatory Disease in Cattle and Mice by Sheldon, I. Martin, Rycroft, Andrew N, Dogan, Belgin, Craven, Melanie, Bromfield, John J, Chandler, Alyssa, Roberts, Mark H, Price, Sian B, Gilbert, Robert O, Simpson, Kenneth W

“…Background: Escherichia coli are widespread in the environment and pathogenic strains cause diseases of mucosal surfaces including the female genital tract…”
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Pathogen-Associated Molecular Patterns Initiate Inflammation and Perturb the Endocrine Function of Bovine Granulosa Cells From Ovarian Dominant Follicles via TLR2 and TLR4 Pathways by Price, Jennifer C, Bromfield, John J, Sheldon, I. Martin

“…Bacterial infections of the uterus or mammary gland commonly cause disease and infertility by perturbing growth and steroidogenesis of the dominant follicle in…”
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Innate immunity and inflammation of the bovine female reproductive tract in health and disease by Sheldon, I Martin, Cronin, James G, Healey, Gareth D, Gabler, Christoph, Heuwieser, Wolfgang, Streyl, Dominik, Bromfield, John J, Miyamoto, Akio, Fergani, Chrys, Dobson, Hilary

“…Mammalian reproductive physiology and the development of viviparity co-evolved with inflammation and immunity over millennia. Many inflammatory mediators…”
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Prepartum heat stress in dairy cows increases postpartum inflammatory responses in blood of lactating dairy cows by Molinari, Paula C.C., Davidson, Brittney D., Laporta, Jimena, Dahl, Geoffrey E., Sheldon, I. Martin, Bromfield, John J.

“…Uterine diseases and heat stress (HS) are major challenges for the dairy cow. Heat stress alters host immune resilience, making cows more susceptible to the…”
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Seminal Fluid Drives Expansion of the CD4⁺CD25⁺ T Regulatory Cell Pool and Induces Tolerance to Paternal Alloantigens in Mice by Robertson, Sarah A, Guerin, Leigh R, Bromfield, John J, Branson, Kim M, Ahlström, Aisling C, Care, Alison S

“…T regulatory (Treg) cells are implicated in maternal immune tolerance of the conceptus at implantation; however, the antigenic and regulatory signals…”
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Seminal fluid and reproduction: much more than previously thought by Bromfield, John J.

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Persistent effects on bovine granulosa cell transcriptome after resolution of uterine disease by Piersanti, Rachel L, Horlock, Anthony D, Block, Jeremy, Santos, José E P, Sheldon, I Martin, Bromfield, John J

“…Metritis is associated with reduced fertility in dairy cows, but the mechanisms are unclear because the disease resolves several weeks before insemination. One…”
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The endometrial transcriptomic response to pregnancy is altered in cows after uterine infection by Dickson, Mackenzie J, Bishop, Jeanette V, Hansen, Thomas R, Sheldon, I Martin, Bromfield, John J

“…Pregnancy induces changes in the transcriptome of the bovine endometrium from 15 days after insemination. However, pregnancy is less likely to occur if cows…”
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Innate Immunity in the Human Endometrium and Ovary by Sheldon, Iain Martin, Bromfield, John J.

“…Citation Sheldon IM, Bromfield JJ. Innate Immunity in the Human Endometrium and Ovary. Am J Reprod Immunol 2011; 66 (Suppl. 1): 63–71 Problem  Microbial…”
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Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins by Ormsby, Thomas J R, Owens, Sian E, Clement, Liam, Mills, Tom J, Cronin, James G, Bromfield, John J, Sheldon, Iain Martin

“…Many species of bacteria produce toxins such as cholesterol-dependent cytolysins that form pores in cell membranes. Membrane pores facilitate infection by…”
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Machine Learning Classifiers for Endometriosis Using Transcriptomics and Methylomics Data by Akter, Sadia, Xu, Dong, Nagel, Susan C, Bromfield, John J, Pelch, Katherine, Wilshire, Gilbert B, Joshi, Trupti

“…Endometriosis is a complex and common gynecological disorder yet a poorly understood disease affecting about 176 million women worldwide and causing…”
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An expansin-like protein expands forage cell walls and synergistically increases hydrolysis, digestibility and fermentation of livestock feeds by fibrolytic enzymes by Pech-Cervantes, Andres A, Ogunade, Ibukun M, Jiang, Yun, Irfan, Muhammad, Arriola, Kathy G, Amaro, Felipe X, Gonzalez, Claudio F, DiLorenzo, Nicolas, Bromfield, John J, Vyas, Diwakar, Adesogan, Adegbola T

“…Bacterial expansin-like proteins have synergistically increased cellulose hydrolysis by cellulolytic enzymes during the initial stages of biofuel production,…”
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Lipopolysaccharide alters CEBPβ signaling and reduces estradiol production in bovine granulosa cells by Dickson, Mackenzie J, Sheldon, I Martin, Bromfield, John J

“…Bacterial infection of the uterus in postpartum dairy cows limits ovarian follicle growth, reduces blood estradiol concentrations, and leads to accumulation of…”
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Human granulosa–luteal cells initiate an innate immune response to pathogen-associated molecules by Ibrahim, Laila A, Kramer, Joseph M, Williams, R Stan, Bromfield, John J

“…The microenvironment of the ovarian follicle is key to the developmental success of the oocyte. Minor changes within the follicular microenvironment can…”
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Seminal fluid and reproduction: much more than previously thought by Bromfield, John J.

“…The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to…”
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Bovine endometrial cells do not mount an inflammatory response to Leptospira by Molinari, Paula C C, Nally, Jarlath E, Bromfield, John J

“…Leptospirosis causes abortion, premature birth, and stillbirth in cattle, but the mechanisms remain unclear. Infected cattle shed intermittently and present a…”
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