Search Results - "BROMBERG, Jacqueline F"

Pre-metastatic niches: organ-specific homes for metastases by Peinado, Héctor, Zhang, Haiying, Matei, Irina R., Costa-Silva, Bruno, Hoshino, Ayuko, Rodrigues, Goncalo, Psaila, Bethan, Kaplan, Rosandra N., Bromberg, Jacqueline F., Kang, Yibin, Bissell, Mina J., Cox, Thomas R., Giaccia, Amato J., Erler, Janine T., Hiratsuka, Sachie, Ghajar, Cyrus M., Lyden, David

“…Key Points Organs of future metastasis are selectively and actively modified by the primary tumour before metastatic spread has occurred. Tumours induce the…”
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Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas by Gao, Sizhi Paul, Mark, Kevin G, Leslie, Kenneth, Pao, William, Motoi, Noriko, Gerald, William L, Travis, William D, Bornmann, William, Veach, Darren, Clarkson, Bayard, Bromberg, Jacqueline F

“…Persistently activated or tyrosine-phosphorylated STAT3 (pSTAT3) is found in 50% of lung adenocarcinomas. pSTAT3 is found in primary adenocarcinomas and cell…”
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Antitumorigenic potential of STAT3 alternative splicing modulation by Zammarchi, Francesca, de Stanchina, Elisa, Bournazou, Eirini, Supakorndej, Teerawit, Martires, Kathryn, Riedel, Elyn, Corben, Adriana D., Bromberg, Jacqueline F., Cartegni, Luca

“…Signal transducer and activator of transcription 3 (STAT3) plays a central role in the activation of multiple oncogenic pathways. Splicing variant STAT3β uses…”
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Linking signaling pathways to transcriptional programs in breast cancer by Osmanbeyoglu, Hatice U, Pelossof, Raphael, Bromberg, Jacqueline F, Leslie, Christina S

“…Cancer cells acquire genetic and epigenetic alterations that often lead to dysregulation of oncogenic signal transduction pathways, which in turn alters…”
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STAT3 negatively regulates thyroid tumorigenesis by Couto, Joana Pinto, Daly, Laura, Almeida, Ana, Knauf, Jeffrey A, Fagin, James A, Sobrinho-Simões, Manuel, Lima, Jorge, Máximo, Valdemar, Soares, Paula, Lyden, David, Bromberg, Jacqueline F

“…Although tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been…”
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Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis by Ortiz, Berenice, Fabius, Armida W. M., Wu, Wei H., Pedraza, Alicia, Brennan, Cameron W., Schultz, Nikolaus, Pitter, Kenneth L., Bromberg, Jacqueline F., Huse, Jason T., Holland, Eric C., Chan, Timothy A.

“…PTPRD , which encodes the protein tyrosine phosphatase receptor-δ, is one of the most frequently inactivated genes across human cancers, including glioblastoma…”
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IL-6 regulates adipose deposition and homeostasis in lymphedema by Cuzzone, Daniel A, Weitman, Evan S, Albano, Nicholas J, Ghanta, Swapna, Savetsky, Ira L, Gardenier, Jason C, Joseph, Walter J, Torrisi, Jeremy S, Bromberg, Jacqueline F, Olszewski, Waldemar L, Rockson, Stanley G, Mehrara, Babak J

“…Lymphedema (LE) is a morbid disease characterized by chronic limb swelling and adipose deposition. Although it is clear that lymphatic injury is necessary for…”
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JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors by Gao, Sizhi P, Chang, Qing, Mao, Ninghui, Daly, Laura A, Vogel, Robert, Chan, Tyler, Liu, Shu Hui, Bournazou, Eirini, Schori, Erez, Zhang, Haiying, Brewer, Monica Red, Pao, William, Morris, Luc, Ladanyi, Marc, Arcila, Maria, Manova-Todorova, Katia, de Stanchina, Elisa, Norton, Larry, Levine, Ross L, Altan-Bonnet, Gregoire, Solit, David, Zinda, Michael, Huszar, Dennis, Lyden, David, Bromberg, Jacqueline F

“…Lung adenocarcinomas with mutant epidermal growth factor receptor (EGFR) respond to EGFR-targeted tyrosine kinase inhibitors (TKIs), but resistance invariably…”
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Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer by Berishaj, Marjan, Gao, Sizhi Paul, Ahmed, Simi, Leslie, Kenneth, Al-Ahmadie, Hikmat, Gerald, William L, Bornmann, William, Bromberg, Jacqueline F

“…Signal transducer and activator of transcription 3 (Stat3) is constitutively tyrosine-phosphorylated in approximately 50% of primary breast carcinomas. A…”
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Requirement of Matrix Metalloproteinase-9 for the Transformation of Human Mammary Epithelial Cells by Stat3-C by Dechow, Tobias N., Pedranzini, Laura, Leitch, Andrea, Leslie, Kenneth, Gerald, William L., Linkov, Irina, Bromberg, Jacqueline F., Darnell, James E.

“…Persistently activated Stat3 is found in many different cancers, including ≈60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3…”
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Predictors of response to CDK4/6i retrial after prior CDK4/6i failure in ER+ metastatic breast cancer by Mai, Nicholas, dos Anjos, Carlos H., Razavi, Pedram, Safonov, Anton, Patil, Sujata, Chen, Yuan, Drago, Joshua Z., Modi, Shanu, Bromberg, Jacqueline F., Dang, Chau T., Liu, Dazhi, Norton, Larry, Robson, Mark, Chandarlapaty, Sarat, Jhaveri, Komal

“…After disease progression on endocrine therapy (ET) plus a CDK4/6 inhibitor, there is no standardized sequence for subsequent treatment lines for estrogen…”
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AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines by Couto, Joana P, Almeida, Ana, Daly, Laura, Sobrinho-Simões, Manuel, Bromberg, Jacqueline F, Soares, Paula

“…Persistent RET activation is a frequent event in papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC). In these cancers, RET activates the…”
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A Phase II Trial of Erlotinib in Combination with Bevacizumab in Patients with Metastatic Breast Cancer by DICKLER, Maura N, RUGO, Hope S, GILEWSKI, Teresa A, BROMBERG, Jacqueline F, SEIDMAN, Andrew D, D'ANDREA, Gabriella M, MOASSER, Mark M, MELISKO, Michele, PARK, John W, DANCEY, Janet, NORTON, Larry, HUDIS, Clifford A, EBERLE, Carey A, BROGI, Edi, CARAVELLI, James F, PANAGEAS, Katherine S, BOYD, Jeff, YEH, Benjamin, LAKE, Diana E, DANG, Chau T

“…Purpose: To evaluate the efficacy and toxicity of erlotinib plus bevacizumab in patients with metastatic breast cancer (MBC), targeting the epidermal growth…”
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Ruxolitinib and exemestane for estrogen receptor positive, aromatase inhibitor resistant advanced breast cancer by Makhlin, Igor, McAndrew, Nicholas P., Wileyto, E. Paul, Clark, Amy S., Holmes, Robin, Bottalico, Lisa N., Mesaros, Clementina, Blair, Ian A., Jeschke, Grace R., Fox, Kevin R., Domchek, Susan M., Matro, Jennifer M., Bradbury, Angela R., Feldman, Michael D., Hexner, Elizabeth O., Bromberg, Jacqueline F., DeMichele, Angela

“…Circulating IL-6, an activator of JAK/STAT signaling, is associated with poor prognosis and aromatase inhibitor (AI) resistance in hormone-receptor positive…”
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Constitutively Activated Stat3 protects Fibroblasts from Serum Withdrawal and UV-Induced Apoptosis and Antagonizes the Proapoptotic Effects of Activated Stat1 by Shen, Yuhong, Devgan, Geeta, Darnell, James E., Bromberg, Jacqueline F.

“…Stats1 and 3 (signal transducers and activators of transcription) can be activated simultaneously, although not necessarily to the same degree or duration, by…”
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The Cell Death Regulator GRIM-19 Is an Inhibitor of Signal Transducer and Activator of Transcription 3 by Zhang, Jun, Yang, Jinbo, Roy, Sanjit K., Tininini, Silvia, Hu, Jiadi, Bromberg, Jacqueline F., Poli, Valeria, Stark, George R., Kalvakolanu, Dhananjaya V.

“…GRIM-19 (gene associated with retinoid-IFN-induced mortality 19), isolated as a cell death activator in a genetic screen used to define mechanisms involved in…”
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Predictors of Progression-Free Survival and Local Tumor Control after Percutaneous Thermal Ablation of Oligometastatic Breast Cancer: Retrospective Study by Ridouani, Fourat, Solomon, Stephen B., Bryce, Yolanda, Bromberg, Jacqueline F., Sofocleous, Constantinos T., Deipolyi, Amy R.

“…To describe ablation of bone, liver, lung, and soft tissue tumors from oligometastatic breast cancer and to define predictors of local progression and…”
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Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial by Scott, Jessica M, Lee, Jasme, Herndon, James E, Michalski, Meghan G, Lee, Catherine P, O’Brien, Kelly A, Sasso, John P, Yu, Anthony F, Rowed, Kylie A, Bromberg, Jacqueline F, Traina, Tiffany A, Gucalp, Ayca, Sanford, Rachel A, Gajria, Devika, Modi, Shanu, Comen, Elisabeth A, D'Andrea, Gabriella, Blinder, Victoria S, Eves, Neil D, Peppercorn, Jeffrey M, Moskowitz, Chaya S, Dang, Chau T, Jones, Lee W

“…Abstract Aims The most appropriate timing of exercise therapy to improve cardiorespiratory fitness (CRF) among patients initiating chemotherapy is not known…”
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First-in-Human Evaluation of Site-Specifically Labeled 89 Zr-Pertuzumab in Patients with HER2-Positive Breast Cancer by Yeh, Randy, O'Donoghue, Joseph A, Jayaprakasam, Vetri Sudar, Mauguen, Audrey, Min, Ryan, Park, Sue, Brockway, Julia P, Bromberg, Jacqueline F, Zhi, W Iris, Robson, Mark E, Sanford, Rachel, Modi, Shanu, Agnew, Brian J, Lyashchenko, Serge K, Lewis, Jason S, Ulaner, Gary A, Zeglis, Brian M

“…Radioimmunoconjugates targeting human epidermal growth factor receptor 2 (HER2) have shown potential to noninvasively visualize HER2-positive tumors. However,…”
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First-in-Human Evaluation of Site-Specifically Labeled 89Zr-Pertuzumab in Patients with HER2-Positive Breast Cancer by Yeh, Randy, O'Donoghue, Joseph A, Jayaprakasam, Vetri Sudar, Mauguen, Audrey, Min, Ryan, Park, Sue, Brockway, Julia P, Bromberg, Jacqueline F, Zhi, W Iris, Robson, Mark E, Sanford, Rachel, Modi, Shanu, Agnew, Brian J, Lyashchenko, Serge K, Lewis, Jason S, Ulaner, Gary A, Zeglis, Brian M

“…Radioimmunoconjugates targeting human epidermal growth factor receptor 2 (HER2) have shown potential to noninvasively visualize HER2-positive tumors. However,…”
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