Search Results - "BRODSKY, Robert A"

Paroxysmal nocturnal hemoglobinuria by Brodsky, Robert A.

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood…”
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How I treat paroxysmal nocturnal hemoglobinuria by Brodsky, Robert A.

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, clonal, complement-mediated hemolytic anemia with protean manifestations. PNH can present as a hemolytic…”
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Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition by Yu, Jia, Yuan, Xuan, Chen, Hang, Chaturvedi, Shruti, Braunstein, Evan M., Brodsky, Robert A.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke,…”
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Complement in hemolytic anemia by Brodsky, Robert A.

“…Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria…”
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How I treat paroxysmal nocturnal hemoglobinuria by Brodsky, Robert A.

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal blood disorder that manifests with hemolytic anemia, bone marrow failure, and thrombosis. Many of…”
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Whole-Genome Sequencing Analysis Reveals High Specificity of CRISPR/Cas9 and TALEN-Based Genome Editing in Human iPSCs by Smith, Cory, Gore, Athurva, Yan, Wei, Abalde-Atristain, Leire, Li, Zhe, He, Chaoxia, Wang, Ying, Brodsky, Robert A., Zhang, Kun, Cheng, Linzhao, Ye, Zhaohui

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Cyclophosphamide and cancer: golden anniversary by Emadi, Ashkan, Jones, Richard J, Brodsky, Robert A

“…Cyclophosphamide is one of the most widely utilized chemotherapeutic and immunosuppressive agents in many combination chemotherapy regimens and autoimmune…”
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Complement in the Pathophysiology of the Antiphospholipid Syndrome by Chaturvedi, Shruti, Brodsky, Robert A, McCrae, Keith R

“…The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). Complement is…”
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Complement dysregulation is associated with severe COVID-19 illness by Yu, Jia, Gerber, Gloria F, Chen, Hang, Yuan, Xuan, Chaturvedi, Shruti, Braunstein, Evan M, Brodsky, Robert A

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia,…”
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Diagnostic utility of telomere length testing in a hospital-based setting by Alder, Jonathan K., Hanumanthu, Vidya Sagar, Strong, Margaret A., DeZern, Amy E., Stanley, Susan E., Takemoto, Clifford M., Danilova, Ludmila, Applegate, Carolyn D., Bolton, Stephen G., Mohr, David W., Brodsky, Robert A., Casella, James F., Greider, Carol W., Jackson, J. Brooks, Armanios, Mary

“…Telomere length (TL) predicts the onset of cellular senescence in vitro but the diagnostic utility of TL measurement in clinical settings is not fully known…”
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Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria by Rother, Russell P, Rollins, Scott A, Mojcik, Christopher F, Brodsky, Robert A, Bell, Leonard

“…The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation can lead to severe pathology. In…”
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Effectiveness of exome and genome sequencing guided by acuity of illness for diagnosis of neurodevelopmental disorders by Soden, Sarah E, Saunders, Carol J, Willig, Laurel K, Farrow, Emily G, Smith, Laurie D, Petrikin, Josh E, LePichon, Jean-Baptiste, Miller, Neil A, Thiffault, Isabelle, Dinwiddie, Darrell L, Twist, Greyson, Noll, Aaron, Heese, Bryce A, Zellmer, Lee, Atherton, Andrea M, Abdelmoity, Ahmed T, Safina, Nicole, Nyp, Sarah S, Zuccarelli, Britton, Larson, Ingrid A, Modrcin, Ann, Herd, Suzanne, Creed, Mitchell, Ye, Zhaohui, Yuan, Xuan, Brodsky, Robert A, Kingsmore, Stephen F

“…Neurodevelopmental disorders (NDDs) affect more than 3% of children and are attributable to single-gene mutations at more than 1000 loci. Traditional methods…”
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Narrative Review : Paroxysmal Nocturnal Hemoglobinuria: The Physiology of Complement-Related Hemolytic Anemia by BRODSKY, Robert A

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematopoietic stem-cell disorder caused by a somatic mutation in a gene known as phosphatidylinositol…”
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Uniform conditioning regardless of donor in bone marrow transplantation for severe aplastic anemia by DeZern, Amy E, Zahurak, Marianna, Jones, Richard J, Brodsky, Robert A

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Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome by Yuan, Xuan, Gavriilaki, Eleni, Thanassi, Jane A, Yang, Guangwei, Baines, Andrea C, Podos, Steven D, Huang, Yongqing, Huang, Mingjun, Brodsky, Robert A

“…Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are…”
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The Phenotype of a Germline Mutation in PIGA: The Gene Somatically Mutated in Paroxysmal Nocturnal Hemoglobinuria by Johnston, Jennifer J., Gropman, Andrea L., Sapp, Julie C., Teer, Jamie K., Martin, Jodie M., Liu, Cyndi F., Yuan, Xuan, Ye, Zhaohui, Cheng, Linzhao, Brodsky, Robert A., Biesecker, Leslie G.

“…Phosphatidylinositol glycan class A (PIGA) is involved in the first step of glycosylphosphatidylinositol (GPI) biosynthesis. Many proteins, including CD55 and…”
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SARS-CoV-2 vaccination and immune thrombotic thrombocytopenic purpura by Shah, Hridaya, Kim, Ann, Sukumar, Senthil, Mazepa, Marshall, Kohli, Ruhail, Braunstein, Evan M., Brodsky, Robert A., Cataland, Spero, Chaturvedi, Shruti

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Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndrome by Vaught, Arthur J, Gavriilaki, Eleni, Hueppchen, Nancy, Blakemore, Karin, Yuan, Xuan, Seifert, Sara M, York, Sarah, Brodsky, Robert A

“…HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a severe variant of pre-eclampsia whose pathogenesis remains unclear. Recent evidence…”
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Comparable composite endpoints after HLA-matched and HLA-haploidentical transplantation with post-transplantation cyclophosphamide by McCurdy, Shannon R, Kasamon, Yvette L, Kanakry, Christopher G, Bolaños-Meade, Javier, Tsai, Hua-Ling, Showel, Margaret M, Kanakry, Jennifer A, Symons, Heather J, Gojo, Ivana, Smith, B Douglas, Bettinotti, Maria P, Matsui, William H, Dezern, Amy E, Huff, Carol Ann, Borrello, Ivan, Pratz, Keith W, Gladstone, Douglas E, Swinnen, Lode J, Brodsky, Robert A, Levis, Mark J, Ambinder, Richard F, Fuchs, Ephraim J, Rosner, Gary L, Jones, Richard J, Luznik, Leo

“…Composite endpoints that not only encompass mortality and relapse, but other critical post-transplant events such as graft-versus-host disease, are being…”
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Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency‐Associated Genes by Mali, Prashant, Chou, Bin‐Kuan, Yen, Jonathan, Ye, Zhaohui, Zou, Jizhong, Dowey, Sarah, Brodsky, Robert A., Ohm, Joyce E., Yu, Wayne, Baylin, Stephen B., Yusa, Kosuke, Bradley, Allan, Meyers, David J., Mukherjee, Chandrani, Cole, Philip A., Cheng, Linzhao

“…We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances the…”
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