Search Results - "BRODIE, Martin J"

Road to refractory epilepsy: The Glasgow story by Brodie, Martin J.

“…Summary This short article reviews 30 years of prospective observations on outcomes relevant to an expanding cohort of adolescent and adult patients with newly…”
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Current position of phenobarbital in epilepsy and its future by Brodie, Martin J., Kwan, Patrick

“…Summary This article reviews the current position of phenobarbital using articles published since 2000 and speculates on its likely future contribution to…”
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Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies by Kwan, Patrick, Arzimanoglou, Alexis, Berg, Anne T., Brodie, Martin J., Allen Hauser, W., Mathern, Gary, Moshé, Solomon L., Perucca, Emilio, Wiebe, Samuel, French, Jacqueline

“…Summary To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate a…”
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Combining antiepileptic drugs—Rational polytherapy? by Brodie, Martin J, Sills, Graeme J

“…Abstract The global introduction of 14 new antiepileptic drugs (AEDs) over the past 20 years as adjunctive treatment in refractory epilepsy has triggered an…”
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Psychiatric side effects and antiepileptic drugs: Observations from prospective audits by Stephen, Linda J, Wishart, Abbie, Brodie, Martin J

“…Abstract Psychiatric comorbidities are common in people with epilepsy. A retrospective study of characteristics associated with withdrawal due to psychiatric…”
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Cannabinoids for epilepsy: What do we know and where do we go? by Brodie, Martin J., Ben‐Menachem, Elinor

“…Summary Over the past decade there has been an increasing interest in using cannabinoids to treat a range of epilepsy syndromes following reports of some…”
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Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009 by Berg, Anne T., Berkovic, Samuel F., Brodie, Martin J., Buchhalter, Jeffrey, Cross, J. Helen, Van Emde Boas, Walter, Engel, Jerome, French, Jacqueline, Glauser, Tracy A., Mathern, Gary W., Moshé, Solomon L., Nordli, Douglas, Plouin, Perrine, Scheffer, Ingrid E.

“…Summary The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, and approaches for…”
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Epilepsy in later life by Brodie, Martin J, MD, Elder, Andrew T, MD, Kwan, Patrick, MD

“…Summary Epilepsy is most likely to develop in later life. The burden of this disorder on health-care resources will rise further as the world's population…”
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Combined analysis of risk factors for SUDEP by Hesdorffer, Dale C., Tomson, Torbjorn, Benn, Emma, Sander, Josemir W., Nilsson, Lena, Langan, Yvonne, Walczak, Thaddeus S., Beghi, Ettore, Brodie, Martin J., Hauser, Allen

“…Summary Purpose:  To pool data from four published case–control studies of sudden unexpected death in epilepsy (SUDEP) with live controls, to increase the…”
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Potential Role of Drug Transporters in the Pathogenesis of Medically Intractable Epilepsy by Kwan, Patrick, Brodie, Martin J.

“…The pathogenesis underlying pharmacoresistance in epilepsy is unclear. One of the candidate mechanisms that has attracted growing interest is the limitation of…”
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Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy by Walker, Lauren Elizabeth, Frigerio, Federica, Ravizza, Teresa, Ricci, Emanuele, Tse, Karen, Jenkins, Rosalind E, Sills, Graeme John, Jorgensen, Andrea, Porcu, Luca, Thippeswamy, Thimmasettappa, Alapirtti, Tiina, Peltola, Jukka, Brodie, Martin J, Park, Brian Kevin, Marson, Anthony Guy, Antoine, Daniel James, Vezzani, Annamaria, Pirmohamed, Munir

“…Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing an unmet medical need. There is evidence that neuroinflammation…”
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Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial by Baulac, Michel, Prof, Brodie, Martin J, Prof, Patten, Anna, PhD, Segieth, Joanna, PhD, Giorgi, Luigi, MD

“…Summary Background Additional options are needed for monotherapy treatment of adults newly diagnosed with partial epilepsy. This trial compares the efficacy…”
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Brivaracetam: a novel antiepileptic drug for focal-onset seizures by Stephen, Linda J., Brodie, Martin J.

“…Brivaracetam (BRV), the n-propyl analogue of levetiracetam (LEV), is the latest antiepileptic drug (AED) to be licensed in Europe and the USA for the…”
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Phenobarbital for the Treatment of Epilepsy in the 21st Century: A Critical Review by Kwan, Patrick, Brodie, Martin J.

“…Phenobarbital (PB) is the most widely used antiepileptic drug (AED) in the developing world and remains a popular choice in many industrialized countries…”
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Do antiepileptic drugs or generalized tonic-clonic seizure frequency increase SUDEP risk? A combined analysis by Hesdorffer, Dale C., Tomson, Torbjorn, Benn, Emma, Sander, Josemir W., Nilsson, Lena, Langan, Yvonne, Walczak, Thaddeus S., Beghi, Ettore, Brodie, Martin J., Hauser, W. Allen

“…Summary Purpose:  In an analysis of four case–control studies of sudden unexpected death in epilepsy (SUDEP), we found that yearly frequency of generalized…”
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Effectiveness of First Antiepileptic Drug by Kwan, Patrick, Brodie, Martin J.

“…Purpose: To investigate the interaction among efficacy, tolerability, and overall effectiveness of the first antiepileptic drug (AED) in patients with newly…”
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Early Identification of Refractory Epilepsy by Kwan, Patrick, Brodie, Martin J

“…Epilepsy is estimated to affect approximately 50 million people worldwide. 1 Although the prognosis for the majority of patients is good, 2 up to 30 percent do…”
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Analysis of pooled phase III trials of adjunctive perampanel for epilepsy: Impact of mechanism of action and pharmacokinetics on clinical outcomes by Kwan, Patrick, Brodie, Martin J, Laurenza, Antonio, FitzGibbon, Hannah, Gidal, Barry E

“…Highlights • Perampanel efficacy may be reduced by concomitant enzyme-inducing AEDs (EIAEDs). • This is due to greater CYP3A4 activity and reduced plasma…”
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Sodium Channel Blockers in the Treatment of Epilepsy by Brodie, Martin J.

“…Sodium channel blockers have been the mainstay of the pharmacological management of focal and generalised tonic–clonic seizures for more than 70 years. The…”
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Editorial: Epidemiology of epilepsy and seizures by Chen, Zhibin, Brodie, Martin J, Ding, Ding, Kwan, Patrick

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