Search Results - "BROADDUS, Russell"

Endometrial Cancer by Lu, Karen H, Broaddus, Russell R

“…Endometrial carcinoma is diagnosed in about 58,500 women in the United States per year. It is linked with obesity, excess estrogen, and the Lynch syndrome…”
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The Changing Landscape of Gynecologic Cancer Mortality in the United States by Giaquinto, Angela N., Broaddus, Russell R., Jemal, Ahmedin, Siegel, Rebecca L.

“…Uterine corpus cancer mortality is now similar to that for ovarian cancer, and the disproportionate burden among Black women is widening…”
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CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence by Kurnit, Katherine C, Kim, Grace N, Fellman, Bryan M, Urbauer, Diana L, Mills, Gordon B, Zhang, Wei, Broaddus, Russell R

“…Although the majority of low grade, early stage endometrial cancer patients will have good survival outcomes with surgery alone, those patients who do recur…”
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Everolimus, Letrozole, and Metformin in Women with Advanced or Recurrent Endometrioid Endometrial Cancer: A Multi-Center, Single Arm, Phase II Study by Soliman, Pamela T, Westin, Shannon N, Iglesias, David A, Fellman, Bryan M, Yuan, Ying, Zhang, Qian, Yates, Melinda S, Broaddus, Russell R, Slomovitz, Brian M, Lu, Karen H, Coleman, Robert L

“…Treatment for patients with recurrent endometrioid endometrial cancer (EEC) are limited as paclitaxel is the only second-line chemotherapy with a response rate…”
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Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors by Janku, Filip, Hong, David S., Fu, Siqing, Piha-Paul, Sarina A., Naing, Aung, Falchook, Gerald S., Tsimberidou, Apostolia M., Stepanek, Vanda M., Moulder, Stacy L., Lee, J. Jack, Luthra, Rajyalakshmi, Zinner, Ralph G., Broaddus, Russell R., Wheler, Jennifer J., Kurzrock, Razelle

“…Despite a wealth of preclinical studies, it is unclear whether PIK3CA or phosphatase and tensin homolog (PTEN) gene aberrations are actionable in the clinical…”
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Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters by Pakish, Janelle B, Zhang, Qian, Chen, Zhongyuan, Liang, Han, Chisholm, Gary B, Yuan, Ying, Mok, Samuel C, Broaddus, Russell R, Lu, Karen H, Yates, Melinda S

“…Recent studies show that colorectal tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy compared…”
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Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma by Liu, Yuexin, Patel, Lalit, Mills, Gordon B, Lu, Karen H, Sood, Anil K, Ding, Li, Kucherlapati, Raju, Mardis, Elaine R, Levine, Douglas A, Shmulevich, Ilya, Broaddus, Russell R, Zhang, Wei

“…Endometrioid endometrial carcinoma (EEC) is the most common form of endometrial carcinoma. The heterogeneous clinical course of EEC is an obstacle to…”
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Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors by Janouskova, Hana, El Tekle, Geniver, Bellini, Elisa, Udeshi, Namrata D, Rinaldi, Anna, Ulbricht, Anna, Bernasocchi, Tiziano, Civenni, Gianluca, Losa, Marco, Svinkina, Tanya, Bielski, Craig M, Kryukov, Gregory V, Cascione, Luciano, Napoli, Sara, Enchev, Radoslav I, Mutch, David G, Carney, Michael E, Berchuck, Andrew, Winterhoff, Boris J N, Broaddus, Russell R, Schraml, Peter, Moch, Holger, Bertoni, Francesco, Catapano, Carlo V, Peter, Matthias, Carr, Steven A, Garraway, Levi A, Wild, Peter J, Theurillat, Jean-Philippe P

“…Different mutations found in endometrial and prostate tumors affecting the substrate-recognition domain of SPOP, a component of the E3 ubiquitin ligase…”
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Treatment of Low-Risk Endometrial Cancer and Complex Atypical Hyperplasia With the Levonorgestrel-Releasing Intrauterine Device by Pal, Navdeep, Broaddus, Russell R, Urbauer, Diana L, Balakrishnan, Nyla, Milbourne, Andrea, Schmeler, Kathleen M, Meyer, Larissa A, Soliman, Pamela T, Lu, Karen H, Ramirez, Pedro T, Ramondetta, Lois, Bodurka, Diane C, Westin, Shannon N

“…OBJECTIVE:To assess efficacy of the levonorgestrel-releasing intrauterine device (LNG-IUD) for treatment of complex atypical hyperplasia or low-grade…”
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Mismatch Repair and Microsatellite Instability Testing for Immune Checkpoint Inhibitor Therapy: Guideline From the College of American Pathologists in Collaboration With the Association for Molecular Pathology and Fight Colorectal Cancer by Bartley, Angela N, Mills, Anne M, Konnick, Eric, Overman, Michael, Ventura, Christina B, Souter, Lesley, Colasacco, Carol, Stadler, Zsofia K, Kerr, Sarah, Howitt, Brooke E, Hampel, Heather, Adams, Sarah F, Johnson, Wenora, Magi-Galluzzi, Cristina, Sepulveda, Antonia R, Broaddus, Russell R

“…The US Food and Drug Administration (FDA) approved immune checkpoint inhibitor therapy for patients with advanced solid tumors that have DNA mismatch repair…”
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Prospective phase II trial of levonorgestrel intrauterine device: nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer by Westin, Shannon N., Fellman, Bryan, Sun, Charlotte C., Broaddus, Russell R., Woodall, Misty L., Pal, Navdeep, Urbauer, Diana L., Ramondetta, Lois M., Schmeler, Kathleen M., Soliman, Pamela T., Fleming, Nicole D., Burzawa, Jennifer K., Nick, Alpa M., Milbourne, Andrea M., Yuan, Ying, Lu, Karen H., Bodurka, Diane C., Coleman, Robert L., Yates, Melinda S.

“…The incidence of complex atypical hyperplasia and early-stage endometrioid endometrial cancer is increasing, in part owing to the epidemic of obesity, which is…”
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Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer by Blando, Jorge, Sharma, Anu, Higa, Maria Gisela, Zhao, Hao, Vence, Luis, Yadav, Shalini S., Kim, Jiseong, Sepulveda, Alejandro M., Sharp, Michael, Maitra, Anirban, Wargo, Jennifer, Tetzlaff, Michael, Broaddus, Russell, Katz, Matthew H. G., Varadhachary, Gauri R., Overman, Michael, Wang, Huamin, Yee, Cassian, Bernatchez, Chantale, Iacobuzio-Donahue, Christine, Basu, Sreyashi, Allison, James P., Sharma, Padmanee

“…Immune checkpoint therapy (ICT) has transformed cancer treatment in recent years; however, treatment response is not uniform across tumor types. The tumor…”
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Clinicopathologic Significance of Mismatch Repair Defects in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study by McMeekin, D Scott, Tritchler, David L, Cohn, David E, Mutch, David G, Lankes, Heather A, Geller, Melissa A, Powell, Matthew A, Backes, Floor J, Landrum, Lisa M, Zaino, Richard, Broaddus, Russell D, Ramirez, Nilsa, Gao, Feng, Ali, Shamshad, Darcy, Kathleen M, Pearl, Michael L, DiSilvestro, Paul A, Lele, Shashikant B, Goodfellow, Paul J

“…The clinicopathologic significance of mismatch repair (MMR) defects in endometrioid endometrial cancer (EEC) has not been definitively established. We…”
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Clinical and molecular characterization of early‐onset colorectal cancer by Willauer, Alexandra N., Liu, Yusha, Pereira, Allan A. L., Lam, Michael, Morris, Jeffrey S., Raghav, Kanwal P. S., Morris, Van K., Menter, David, Broaddus, Russell, Meric‐Bernstam, Funda, Hayes‐Jordan, Andrea, Huh, Winston, Overman, Michael J., Kopetz, Scott, Loree, Jonathan M.

“…Background Colorectal cancer (CRC) incidence is increasing in adults younger than 50 years. This study evaluated clinical and molecular features to identify…”
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Endometrial Cancer. Reply by Lu, Karen H, Broaddus, Russell R

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Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials by Meric-Bernstam, Funda, Brusco, Lauren, Shaw, Kenna, Horombe, Chacha, Kopetz, Scott, Davies, Michael A, Routbort, Mark, Piha-Paul, Sarina A, Janku, Filip, Ueno, Naoto, Hong, David, De Groot, John, Ravi, Vinod, Li, Yisheng, Luthra, Raja, Patel, Keyur, Broaddus, Russell, Mendelsohn, John, Mills, Gordon B

“…We report the experience with 2,000 consecutive patients with advanced cancer who underwent testing on a genomic testing protocol, including the frequency of…”
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Molecular Profile of Advanced Thyroid Carcinomas by Next-Generation Sequencing: Characterizing Tumors Beyond Diagnosis for Targeted Therapy by Chen, Hui, Luthra, Rajyalakshmi, Routbort, Mark J, Patel, Keyur P, Cabanillas, Maria E, Broaddus, Russell R, Williams, Michelle D

“…Next-generation sequencing (NGS) for molecular diagnostics allows simultaneous testing of activating oncogenes and tumor suppressor mutations in multiple…”
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MIG-6 Is Critical for Progesterone Responsiveness in Human Complex Atypical Hyperplasia and Early-Stage Endometrial Cancer by Jeong, Olivia, Broaddus, Russell R, Lessey, Bruce A, Risinger, John I, Hunter, Mark I, Kim, Tae Hoon

“…Women with complex atypical hyperplasia (CAH) or early-stage endometrioid endometrial cancer (EEC) are candidates for fertility preservation. The most common…”
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Targeted next-generation sequencing of endometrial cancer and matched circulating tumor DNA: identification of plasma-based, tumor-associated mutations in early stage patients by Bolivar, Ana M., Luthra, Rajyalakshmi, Mehrotra, Meenakshi, Chen, Wei, Barkoh, Bedia A., Hu, Peter, Zhang, Wei, Broaddus, Russell R.

“…There is currently no blood-based marker in routine use for endometrial cancer patients. Such a marker could potentially be used for early detection, but it…”
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Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes by Loree, Jonathan M, Pereira, Allan A L, Lam, Michael, Willauer, Alexandra N, Raghav, Kanwal, Dasari, Arvind, Morris, Van K, Advani, Shailesh, Menter, David G, Eng, Cathy, Shaw, Kenna, Broaddus, Russell, Routbort, Mark J, Liu, Yusha, Morris, Jeffrey S, Luthra, Rajyalakshmi, Meric-Bernstam, Funda, Overman, Michael J, Maru, Dipen, Kopetz, Scott

“…Colorectal cancers are classified as right/left-sided based on whether they occur before/after the splenic flexure, with established differences in molecular…”
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