Search Results - "BRITTON, Robert G"

Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities by Brown, Karen, Theofanous, Despoina, Britton, Robert G, Aburido, Grandezza, Pepper, Coral, Sri Undru, Shanthi, Howells, Lynne

“…Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence to…”
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Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice by Cai, Hong, Scott, Edwina, Kholghi, Abeer, Andreadi, Catherine, Rufini, Alessandro, Karmokar, Ankur, Britton, Robert G, Horner-Glister, Emma, Greaves, Peter, Jawad, Dhafer, James, Mark, Howells, Lynne, Ognibene, Ted, Malfatti, Michael, Goldring, Christopher, Kitteringham, Neil, Walsh, Joanne, Viskaduraki, Maria, West, Kevin, Miller, Andrew, Hemingway, David, Steward, William P, Gescher, Andreas J, Brown, Karen

“…Resveratrol is widely promoted as a potential cancer chemopreventive agent, but a lack of information on the optimal dose prohibits rationally designed trials…”
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Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients by PATEL, Ketan R, BROWN, Victoria A, BRENNER, Dean E, STEWARD, William P, GESCHER, Andreas J, BROWN, Karen, JONES, Donald J. L, BRITTON, Robert G, HEMINGWAY, David, MILLER, Andrew S, WEST, Kevin P, BOOTH, Tristan D, PERLOFF, Marjorie, CROWELL, James A

“…Resveratrol is a phytochemical with chemopreventive activity in preclinical rodent models of colorectal carcinogenesis. Antiproliferation is one of the many…”
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Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells by Alaqbi, Saif Sattar, Burke, Lynsey, Guterman, Inna, Green, Caleb, West, Kevin, Palacios-Gallego, Raquel, Cai, Hong, Alexandrou, Constantinos, Myint, Ni Ni Moe, Parrott, Emma, Howells, Lynne M, Higgins, Jennifer A, Jones, Donald J L, Singh, Rajinder, Britton, Robert G, Tufarelli, Cristina, Thomas, Anne, Rufini, Alessandro

“…Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline…”
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Prolonged Biologically Active Colonic Tissue Levels of Curcumin Achieved After Oral Administration—A Clinical Pilot Study Including Assessment of Patient Acceptability by IRVING, Glen R. B, HOWELLS, Lynne M, HEMINGWAY, David, MILLER, Andrew S, BROWN, Karen, GESCHER, Andreas J, STEWARD, William P, SALE, Stewart, KRALJ-HANS, Ines, ATKIN, Wendy S, CLARK, Susan K, BRITTON, Robert G, JONES, Donald J. L, SCOTT, Edwina N, BERRY, David P

“…Curcumin, the main constituent of turmeric, is suspected to possess cancer chemopreventive properties. Pharmacokinetic and pharmacodynamic parameters have been…”
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Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms by Britton, Robert G., Kovoor, Christina, Brown, Karen

“…To truly understand the mechanisms through which resveratrol exerts its biological effects, the key direct interactions between resveratrol and its target…”
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Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy by Cai, Hong, Sale, Stewart, Schmid, Ralf, Britton, Robert G, Brown, Karen, Steward, William P, Gescher, Andreas J

“…Flavonoids occur ubiquitously in plants, and some possess preclinical cancer chemopreventive activity. Little is known about molecular features that mediate…”
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The Janus-like role of proline metabolism in cancer by Burke, Lynsey, Guterman, Inna, Palacios Gallego, Raquel, Britton, Robert G., Burschowsky, Daniel, Tufarelli, Cristina, Rufini, Alessandro

“…The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in the metabolic rewiring that sustains cancer cells proliferation,…”
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Dose-Response Relationships for N7-(2-Hydroxyethyl)Guanine Induced by Low-Dose [14C]Ethylene Oxide: Evidence for a Novel Mechanism of Endogenous Adduct Formation by MARSDEN, Debbie A, JONES, Donald J. L, BRITON, Robert G, OGNIBENE, Ted, UBICK, Esther, JOHNSON, George E, FARMER, Peter B, BROWN, Karen

“…Ethylene oxide (EO) is widely used in the chemical industry and is also formed in humans through the metabolic oxidation of ethylene, generated during…”
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Design, preparation and biological evaluation of new Rociletinib-inspired analogs as irreversible EGFR inhibitors to treat non-small-cell-lung cancer by Konsue, Adchata, Lamtha, Thomanai, Gleeson, Duangkamol, Jones, Donald J.L., Britton, Robert G., Pickering, James D., Choowongkomon, Kiattawee, Gleeson, M. Paul

“…Synthesis, in vitro SAR and Computational Evaluation of Rocelitinib-derived Covalent Inhibitors for the Treatment of EGFR non-small-cell-lung cancers. [Display…”
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Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence by Patel, Ketan R, Andreadi, Catherine, Britton, Robert G, Horner-Glister, Emma, Karmokar, Ankur, Sale, Stewart, Brown, Victoria A, Brenner, Dean E, Singh, Rajinder, Steward, William P, Gescher, Andreas J, Brown, Karen

“…The phytochemical resveratrol has been shown to exert numerous health benefits in preclinical studies, but its rapid metabolism and resulting poor…”
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Resveratrol-sulfates provide an intracellular reservoir for generation of parent resveratrol, which induces autophagy in cancer cells by Andreadi, Catherine, Britton, Robert G, Patel, Ketan R, Brown, Karen

“…Resveratrol has many proposed health benefits, including the prevention of cancers, but its low bioavailability is considered a limiting factor in translating…”
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Distribution and metabolism of [14C]-resveratrol in human prostate tissue after oral administration of a “dietary-achievable” or “pharmacological” dose: what are the implications for anticancer activity? by Cai, Hong, Scott, Edwina N, Britton, Robert G, Parrott, Emma, Ognibene, Ted J, Malfatti, Michael, Khan, Masood, Steward, William P, Brown, Karen

“…The dietary polyphenol resveratrol prevents various malignancies in preclinical models, including prostate cancer. Despite attempts to translate findings to…”
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Detection of Plasma Curcuminoids from Dietary Intake of Turmeric‐Containing Food in Human Volunteers by Mahale, Jagdish, Singh, Rajinder, Howells, Lynne M., Britton, Robert G., Khan, Sameena M., Brown, Karen

“…Scope Curcumin (from turmeric), has been extensively investigated for potential beneficial properties in numerous diseases. Most work has focused on…”
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Synthesis of the flavonoid 3′,4′,5′-trimethoxyflavonol and its determination in plasma and tissues of mice by HPLC with fluorescence detection by Britton, Robert G., Fong, Isabel, Saad, Shaban, Brown, Karen, Steward, William P., Gescher, Andreas, Sale, Stewart

“…3′,4′,5′-Trimethoxyflavonol (TMFol) was synthesized as a potential colorectal cancer chemopreventive agent. An HPLC method for determination for TMFol in…”
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Determination of N7‐glycidamide guanine adducts in human blood DNA following exposure to dietary acrylamide using liquid chromatography/tandem mass spectrometry by Jones, Donald J. L., Singh, Raj, Emms, Victoria, Farmer, Peter B., Grant, Derryn, Quinn, Paulene, Maxwell, Colleen, Mina, Antria, Ng, Leong L., Schumacher, Sandra, Britton, Robert G.

“…Rationale Acrylamide is classified as a probable human carcinogen that is metabolised to glycidamide, which can covalently bind to DNA. The aim of this study…”
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3D Printing Workshop Activity That Aids Representation of Molecules and Student Comprehension of Shape and Chirality by Dickenson, Charlotte E, Blackburn, Richard A. R, Britton, Robert G

“…Traditionally, there is often a shortfall in the ability of students to draw and visualize molecules in set orientations and assign their stereochemistry. We…”
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An HPLC‐UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications by Mahale, Jagdish, Howells, Lynne M., Singh, Rajinder, Britton, Robert G., Cai, Hong, Brown, Karen

“…Curcumin, derived from turmeric, has been extensively investigated for its broad spectrum of biological activities. Previously reported HPLC‐UV methods have…”
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BTK mutations in patients with chronic lymphocytic leukemia receiving tirabrutinib by Jackson, Ross A., Britton, Robert G., Jayne, Sandrine, Lehmann, Susann, Cowley, Caroline M., Trethewey, Christopher S., Smith, Victoria M., Schmid, Ralf, Fegan, Christopher, Walter, Harriet S., Dyer, Martin J. S.

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Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents by Britton, Robert G., Horner-Glister, Emma, Pomenya, Odette A., Smith, Ewan E., Denton, Roanne, Jenkins, Paul R., Steward, William P., Brown, Karen, Gescher, Andreas, Sale, Stewart

“…A library of flavonol analogues was synthesised and evaluated as potential anticancer agents against a human prostate cancer cell line, 22rν1. Compounds 3, 8…”
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