Search Results - "BRISTOW, Linda J"

The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators; A Potential Translational Biomarker for Drug Development by Keavy, Deborah, Bristow, Linda J, Sivarao, Digavalli V, Batchelder, Margaret, King, Dalton, Thangathirupathy, Srinivasan, Macor, John E, Weed, Michael R

“…The antidepressant activity of the N-methyl-D-aspartate (NMDA) receptor channel blocker, ketamine, has led to the investigation of negative allosteric…”
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TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding by Dedic, Nina, Wang, Lien, Hajos-Korcsok, Eva, Hecksher-Sørensen, Jacob, Roostalu, Urmas, Vickers, Steven P., Wu, Serena, Anacker, Christoph, Synan, Colleen, Jones, Philip G., Milanovic, Snezana, Hopkins, Seth C., Bristow, Linda J., Koblan, Kenneth S.

“…Metabolic Syndrome, which can be induced or exacerbated by current antipsychotic drugs (APDs), is highly prevalent in schizophrenia patients. Recent…”
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Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning by Weed, Michael R, Polino, Joseph, Signor, Laura, Bookbinder, Mark, Keavy, Deborah, Benitex, Yulia, Morgan, Daniel G, King, Dalton, Macor, John E, Zaczek, Robert, Olson, Richard, Bristow, Linda J

“…Agonists at the nicotinic acetylcholine alpha 7 receptor (nAChR α7) subtype have the potential to treat cognitive deficits in patients with Alzheimer's disease…”
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The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia by Bristow, Linda J, Easton, Amy E, Li, Yu-Wen, Sivarao, Digavalli V, Lidge, Regina, Jones, Kelli M, Post-Munson, Debra, Daly, Christopher, Lodge, Nicholas J, Gallagher, Lizbeth, Molski, Thaddeus, Pieschl, Richard, Chen, Ping, Hendricson, Adam, Westphal, Ryan, Cook, James, Iwuagwu, Christiana, Morgan, Daniel, Benitex, Yulia, King, Dalton, Macor, John E, Zaczek, Robert, Olson, Richard

“…The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia…”
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Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents by Pieschl, Rick L., Miller, Regina, Jones, Kelli M., Post-Munson, Debra J., Chen, Ping, Newberry, Kimberly, Benitex, Yulia, Molski, Thaddeus, Morgan, Daniel, McDonald, Ivar M., Macor, John E., Olson, Richard E., Asaka, Yukiko, Digavalli, Siva, Easton, Amy, Herrington, James, Westphal, Ryan S., Lodge, Nicholas J., Zaczek, Robert, Bristow, Linda J., Li, Yu-Wen

“…The α7 nicotinic acetylcholine receptor is thought to play an important role in human cognition. Here we describe the in vivo effects of BMS-902483, a…”
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Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents by Robertson, Alan S, Majchrzak, Mark J, Smith, Courtney M, Gagnon, Robert C, Devidze, Nino, Banks, Glen B, Little, Sean C, Nabbie, Fizal, Bounous, Denise I, DiPiero, Janet, Jacobsen, Leslie K, Bristow, Linda J, Ahlijanian, Michael K, Stimpson, Stephen A

“…Highlights • New immunoassays were developed for quantification of amino-terminal fragments of titin in urine. • A 365-fold increase in urinary titin…”
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Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment by Srikumar, Bettadapura N., Paschapur, Mahesh, Kalidindi, Narasimharaju, Adepu, Bharath, Das, Manish L., Sreedhara, Muppana V., Kuchibhotla, Vijaya K., Pieschl, Rick L., Li, Yu-Wen, Ega, Durga Shiva Prasad, Louis, Justin V., Murugesan, Senthilkumar, Naidu, Pattipati S., Ramarao, Manjunath, Bristow, Linda J., Vikramadithyan, Reeba K.

“…Approximately 30–60% of patients treated with existing antidepressants fail to achieve remission of depressive symptoms leading to Treatment Resistant…”
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Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain by Dzierba, Carolyn D., Dasgupta, Bireshwar, Karageorge, George, Kostich, Walter, Hamman, Brian, Allen, Jason, Esposito, Kim M., Padmanabha, Ramesh, Grace, James, Lentz, Kimberley, Morrison, John, Morgan, Daniel, Easton, Amy, Bourin, Clotilde, Browning, Marc R., Rajamani, Ramkumar, Good, Andrew, Parker, Dawn D., Muckelbauer, Jodi K., Khan, Javed, Camac, Daniel, Ghosh, Kaushik, Halan, Vivek, Lippy, Jonathan S., Santone, Kenneth S., Denton, R. Rex, Westphal, Ryan, Bristow, Linda J., Conway, Charles M., Bronson, Joanne J., Macor, John E.

“…Adaptor protein 2-associated kinase 1 (AAK1) is a member of the Ark1/Prk1 family of serine/threonine kinases and plays a role in modulating receptor…”
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Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents by Kinney, Gene G, Burno, Maryann, Campbell, Una C, Hernandez, Lisa M, Rodriguez, Dana, Bristow, Linda J, Conn, P Jeffrey

“…Use-dependent N-methyl-d-aspartate receptor (NMDAR) antagonists produce behaviors in human volunteers that resemble schizophrenia and exacerbate those…”
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Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides by Anderson, Brian R., Jensen, Marianne L., Hagedorn, Peter H., Little, Sean C., Olson, Richard E., Ammar, Ron, Kienzle, Bernadette, Thompson, John, McDonald, Ivar, Mercer, Stephen, Vikesaa, Jonas, Nordbo, Bettina, Iben, Larry, Cao, Yang, Natale, Joanne, Dalton-Kay, Greg, Cacace, Angela, Hansen, Bo R., Hedtjärn, Maj, Koch, Troels, Bristow, Linda J.

“…Hundreds of dominant-negative myosin mutations have been identified that lead to hypertrophic cardiomyopathy, and the biomechanical link between mutation and…”
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Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2 by Schaffhauser, Hervé, Rowe, Blake A, Morales, Sylvia, Chavez-Noriega, Laura E, Yin, Ruoyuan, Jachec, Christine, Rao, Sara P, Bain, Gretchen, Pinkerton, Anthony B, Vernier, Jean-Michel, Bristow, Linda J, Varney, Mark A, Daggett, Lorrie P

“…In the present study, we describe the characterization of a positive allosteric modulator at metabotropic glutamate subtype 2 receptors (mGluR2)…”
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Current and Novel Approaches to the Drug Treatment of Schizophrenia by Rowley, Michael, Bristow, Linda J, Hutson, Peter H

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TAAR1 and 5-HT1B receptor agonists attenuate autism-like irritability and aggression in rats prenatally exposed to valproic acid by Wang, Lien, Clark, Erin A., Hanratty, Lynsey, Koblan, Kenneth S., Foley, Andrew, Dedic, Nina, Bristow, Linda J.

“…Despite the rising prevalence of autism spectrum disorder (ASD), there remains a significant unmet need for pharmacotherapies addressing its core and…”
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TAAR1 agonist ulotaront modulates striatal and hippocampal glutamate function in a state-dependent manner by Yang, Sung M, Ghoshal, Ayan, Hubbard, Jeffrey M, Gackière, Florian, Teyssié, Romain, Neale, Stuart A, Hopkins, Seth C, Koblan, Kenneth S, Bristow, Linda J, Dedic, Nina

“…Aberrant dopaminergic and glutamatergic function, particularly within the striatum and hippocampus, has repeatedly been associated with the pathophysiology of…”
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Group II mGlu Receptor Activation Suppresses Norepinephrine Release in the Ventral Hippocampus and Locomotor Responses to Acute Ketamine Challenge by LORRAIN, Daniel S, SCHAFFHAUSER, Hervé, VERNIER, Jean-Michel, BRISTOW, Linda J, CAMPBELL, Una C, BACCEI, Christopher S, CORREA, Lucia D, ROWE, Blake, RODRIGUEZ, Dana E, ANDERSON, Jeffery J, VARNEY, Mark A, PINKERTON, Anthony B

“…Group II mGlu receptor agonists (eg LY379268 and LY354740) have been shown to reverse many of the behavioral responses to PCP as well as glutamate release…”
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Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2‑Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain by Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C.M. Vijaya, Brown, Jeffrey M, Bristow, Linda J, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel, Kiefer, Susan E, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Easton, Amy, Lippy, Jonathan S, Surti, Neha, Pattipati, Sreenivasulu N, Dokania, Manoj, Elavazhagan, Saravanan, Dandapani, Kumaran, Hamman, Brian D, Allen, Jason, Kostich, Walter, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

“…Effective treatment of chronic pain, in particular neuropathic pain, without the side effects that often accompany currently available treatment options is an…”
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Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain by Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V, Senapati, Arun, Bristow, Linda J, Meanwell, Nicholas A, Thompson, Lorin A, Dzierba, Carolyn

“…3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Nav1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse…”
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Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus by Graef, John D, Newberry, Kimberly, Newton, Amy, Pieschl, Rick, Shields, Eric, Luan, Fu-ni, Simmermacher, Jean, Luchetti, David, Schaeffer, Eric, Li, Yu-Wen, Kiss, Laszlo, Bristow, Linda J

“…Abstract The long lasting antidepressant response seen following acute, i.v. ketamine administration in patients with treatment-resistant depression (TRD) is…”
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The effect of (±)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze by Guscott, Martin R., Clarke, Hannah F., Murray, Fraser, Grimwood, Sarah, Bristow, Linda J., Hutson, Peter H.

“…It is well established that the NMDA receptor antagonists block hippocampal long-term potentiation and impair acquisition in the Morris watermaze task,…”
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Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats by Jones, Kelli M., McDonald, Ivar M., Bourin, Clotilde, Olson, Richard E., Bristow, Linda J., Easton, Amy

“…Rationale Attentional set shifting, a measure of executive function, is impaired in schizophrenia patients. Current standard of care has little therapeutic…”
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