Search Results - "BRISSOT, P"
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The origin and spread of the HFE-C282Y haemochromatosis mutation
Published in Human genetics (01-09-2004)“…The mutation responsible for most cases of genetic haemochromatosis in Europe (HFE C282Y) appears to have been originated as a unique event on a chromosome…”
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A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis
Published in Haematologica (Roma) (01-05-2009)“…1 Inserm U522, IFR140; University of Rennes 1 2 Molecular Genetic Department 3 French National Centre for Rare Genetic Iron Overload Diseases 4 Liver Disease…”
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Insulin resistance–associated hepatic iron overload
Published in Gastroenterology (New York, N.Y. 1943) (01-11-1999)“…Background & Aims: Hepatic iron overload has been reported in various metabolic conditions, including the insulin-resistance syndrome (IRS) and nonalcoholic…”
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Hereditary hemochromatosis: presenting manifestations and diagnostic delay
Published in La revue de medecine interne (01-03-2014)“…Hereditary hemochromatosis is characterized by an excessive absorption and progressive accumulation of iron in the liver, the pancreas, the heart, and the…”
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Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis
Published in Gastroenterology (New York, N.Y. 1943) (01-10-1998)“…Background & Aims: The diagnosis of hemochromatosis is now possible for C282Y homozygous patients using noninvasive molecular genetic tests. The aim of this…”
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P743 IMPACT OF BASELINE SERUM FERRITIN ON SURVIVAL OF PATIENTS WITH CHRONIC HEPATITIS C AFTER A 15 YEARS FOLLOW-UP
Published in Journal of hepatology (01-04-2014)Get full text
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Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing
Published in Journal of hepatology (2002)“…Background/Aims : The aim of our study was to evaluate the proportion of patients with severe alcoholic cirrhosis who would need orthotopic liver…”
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Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice
Published in Gut (01-11-2002)“…Background: Although much progress has been made recently in characterising the proteins involved in duodenal iron trafficking, regulation of intestinal iron…”
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The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis
Published in Hepatology (Baltimore, Md.) (01-01-1997)“…The aim of this study was to investigate the relationship between iron overload, age, and clinical symptoms in genetic hemochromatosis. The relationship was…”
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Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism
Published in Cell proliferation (01-10-2007)“… Objective: Iron loading has been observed to have a hyperproliferative effect on hepatocytes in vitro and on tumour cells in vivo; removal of this iron…”
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Phenotypic expression of HFE mutations: A French study of 1110 unrelated iron-overloaded patients and relatives
Published in Gastroenterology (New York, N.Y. 1943) (01-02-1999)“…Background & Aims: Two mutations have been described in the HFE gene: C282Y and H63D. The aim of this study was to determine the phenotype of the different HFE…”
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A genotypic study of 217 unrelated probands diagnosed as “genetic hemochromatosis” on “classical” phenotypic criteria
Published in Journal of hepatology (01-04-1999)“…Background/Aims: The HFE gene is a crucial candidate gene for hemochromatosis. The aims of this study were to assess the HFE genotypic profile in a large…”
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Effects of phlebotomy therapy on cytochrome P450 2e1 activity and oxidative stress markers in dysmetabolic iron overload syndrome: a randomized trial
Published in Alimentary pharmacology & therapeutics (15-10-2006)“…Summary Aim To assess the effects of iron removal on cytochrome P450 2E1 activity and oxidative stress in dysmetabolic iron overload syndrome. Methods…”
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Hemochromatosis: diagnosis and quantification of liver iron with gradient-echo MR imaging
Published in Radiology (01-11-1994)“…To assess the role of magnetic resonance (MR) imaging in detection and quantification of liver iron overload. MR imaging at 0.5 T was prospectively performed…”
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