Search Results - "BRISCO, Michael J"

Quantification of RNA integrity and its use for measurement of transcript number by Brisco, Michael J, Morley, Alexander A

“…RNA degradation can distort or prevent measurement of RNA transcripts. A mathematical model for degradation was constructed, based on random RNA damage and…”
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Incorporation of measurement of DNA integrity into qPCR assays by Brisco, Michael J, Latham, Sue, Bartley, Paul A, Morley, Alexander A

“…Optimal accuracy of quantitative PCR (qPCR) requires correction for integrity of the target sequence. Here we combine the mathematics of the Poisson…”
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Importance of Minimal Residual Disease Testing During the Second Year of Therapy for Children With Acute Lymphoblastic Leukemia by Marshall, Glenn M, Haber, Michelle, Kwan, Edward, Zhu, Ling, Ferrara, Daniella, Xue, Chengyuan, Brisco, Michael J, Sykes, Pamela J, Morley, Alexander, Webster, Boyd, Dalla Pozza, Luciano, Waters, Keith, Norris, Murray D

“…A high level of minimal residual disease (MRD) after induction chemotherapy in children with acute lymphoblastic leukemia (ALL) is an indicator of relative…”
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Antisense PCR: A simple and robust method for performing nested single-tube PCR by Brisco, Michael J., Bartley, Paul A., Morley, Alexander A.

“…To overcome the disadvantages of two-round nested PCR, we developed a simple and robust closed single-tube nested PCR method (antisense PCR). The method uses…”
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Sensitive and Specific Measurement of Minimal Residual Disease in Acute Lymphoblastic Leukemia by Morley, Alexander A, Latham, Sue, Brisco, Michael J, Sykes, Pamela J, Sutton, Rosemary, Hughes, Elizabeth, Wilczek, Vicki, Budgen, Bradley, van Zanten, Katrina, Kuss, Bryone J, Venn, Nicola C, Norris, Murray D, Crock, Catherine, Storey, Colin, Revesz, Tamas, Waters, Keith

“…A sensitive and specific quantitative real-time polymerase chain reaction method, involving three rounds of amplification with two allele-specific…”
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Determining the Repertoire of IGH Gene Rearrangements to Develop Molecular Markers for Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia by Brisco, Michael J, Latham, Sue, Sutton, Rosemary, Hughes, Elizabeth, Wilczek, Vicki, van Zanten, Katrina, Budgen, Bradley, Bahar, Anita Y, Malec, Maria, Sykes, Pamela J, Kuss, Bryone J, Waters, Keith, Venn, Nicola C, Giles, Jodie E, Haber, Michelle, Norris, Murray D, Marshall, Glenn M, Morley, Alexander A

“…Molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia were identified by determining, at the time of diagnosis, the…”
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Effect of age on the repertoire of cytotoxic memory (CD8+CD45RO+) T cells in peripheral blood: The use of rearranged T cell receptor γ genes as clonal markers by Dare, Raellene, Sykes, Pamela J., Morley, Alexander A., Brisco, Michael J.

“…We have established a method to estimate the number of clones in peripheral blood, using rearranged T cell receptor γ genes as clonal markers, selecting cells…”
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Improved Measurement of Minimal Residual Disease (MRD) by Morley, Alexander A., Latham, Sue, Brisco, Michael J., Sykes, Pamela J., Kuss, Bryone, Waters, Keith

“…A new and improved method for measurement of minimal residual disease (MRD) was developed. Method the total repertoire of leukaemic rearrangements of the…”
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The Repertoire of Gene Rearrangements in Acute Lymphoblastic Leukemia by Morley, Alexander A., Brisco, Michael J., Sykes, Pamela J., Latham, Sue, Hughes, Elizabeth, Wilczek, Vicki, Kuss, Bryone J., Waters, Keith

“…Rearrangements of the immunoglobulin and T-cell receptor genes provide molecular markers for clones in acute lymphoblastic leukemia (ALL). Determination of the…”
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Outcome prediction in childhood acute lymphoblastic leukaemia by molecular quantification of residual disease at the end of induction by Brisco, M J, Condon, J, Hughes, E, Neoh, S H, Sykes, P J, Seshadri, R, Toogood, I, Waters, K, Tauro, G, Ekert, H

“…Methods to detect and quantify minimal residual disease (MRD) after chemotherapy for acute lymphoblastic leukaemia (ALL) could improve treatment by identifying…”
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Relationship Between Minimal Residual Disease and Outcome in Adult Acute Lymphoblastic Leukemia by Brisco, Michael J., Hughes, Elizabeth, Neoh, Sim H., Sykes, Pamela J., Bradstock, Kenneth, Enno, Arno, Szer, Jeffrey, McCaul, Kieran, Morley, Alexander A.

“…In children with acute lymphoblastic leukemia (ALL), the level of minimal residual disease (MRD) at the end of induction strongly predicts outcome, presumably…”
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Monoclonality in B-Lymphoproliferative Disorders Detected at the DNA Level by Trainor, Kevin J., Brisco, Michael J., Story, Colin J., Morley, Alexander A.

“…A new method was developed for detection of monoclonality at the DNA level in B-lymphoproliferative disease using the polymerase chain reaction and consensus…”
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Early resistance to therapy during induction in childhood acute lymphoblastic leukemia by BRISCO, Michael J, SYKES, Pamela J, DOLMAN, Gaynor, HUGHES, Elizabeth, NEOH, Sim-Hee, LIMING PENG, SNELL, Lesley E, TOOGOOD, Ian R. G, RICE, Michael S, MORLEY, Alexander A

“…Many patients with acute lymphoblastic leukemia (ALL) are not cured by current therapy because of the development of drug resistance. It is not clear when…”
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Advancement of Multiple Myeloma From Diagnosis Through Plateau Phase to Progression Does Not Involve a New B-Cell Clone: Evidence From the Ig Heavy Chain Gene by Ralph, Quentin M., Brisco, Michael J., Joshua, Doug E., Brown, Ross, Gibson, John, Morley, Alexander A.

“…The Ig heavy chain (IgH) gene was used as a marker to investigate clonal succession and the origin of the neoplastic cell in multiple myeloma. The polymerase…”
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Comparison of myeloma cell contamination of bone marrow and peripheral blood stem cell harvests by Henry, J M, Sykes, P J, Brisco, M J, To, L B, Juttner, C A, Morley, A A

“…lt could be speculated for patients with myeloma and other lymphoproliferative disorders that peripheral blood stem cells may be preferable to bone marrow for…”
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A Method for Assessing Strand Breaks in DNA by Peng, Liming, Brisco, Michael J., Morley, Alexander A.

“…A simple method has been developed to assess strand breaks in extracted DNA. The method uses the enzyme terminal deoxynucleotidyl transferase (TDT) to…”
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In vitro translation of the double-stranded RNA genome from beet cryptic virus 1 by Accotto, G.P, Brisco, M.J, Hull, R

“…Department of Virus Research, John Innes Institute, Colney Lane, Norwich NR4 7UH, U.K. The double-stranded RNA genome of beet cryptic virus 1 (BCV 1) has been…”
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