Search Results - "BRINKHAUS, Heike"

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling by Britschgi, Adrian, Bill, Anke, Brinkhaus, Heike, Rothwell, Christopher, Clay, Ieuan, Duss, Stephan, Rebhan, Michael, Raman, Pichai, Guy, Chantale T, Wetzel, Kristie, George, Elizabeth, Popa, M Oana, Lilley, Sarah, Choudhury, Hedaythul, Gosling, Martin, Wang, Louis, Fitzgerald, Stephanie, Borawski, Jason, Baffoe, Jonathan, Labow, Mark, Gaither, L Alex, Bentires-Alj, Mohamed

“…The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in…”
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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop by Aceto, Nicola, Sausgruber, Nina, Brinkhaus, Heike, Gaidatzis, Dimos, Martiny-Baron, Georg, Mazzarol, Giovanni, Confalonieri, Stefano, Quarto, Micaela, Hu, Guang, Balwierz, Piotr J, Pachkov, Mikhail, Elledge, Stephen J, van Nimwegen, Erik, Stadler, Michael B, Bentires-Alj, Mohamed

“…The authors uncover a role for the tyrosine phosphatase SHP2 in the propagation and maintenance of breast cancer tumor initiating cells. This role of SHP2…”
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Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium by Meier-Abt, Fabienne, Milani, Emanuela, Roloff, Tim, Brinkhaus, Heike, Duss, Stephan, Meyer, Dominique S, Klebba, Ina, Balwierz, Piotr J, van Nimwegen, Erik, Bentires-Alj, Mohamed

“…Early pregnancy has a strong protective effect against breast cancer in humans and rodents, but the underlying mechanism is unknown. Because breast cancers are…”
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Glutamate receptors regulate actin-based plasticity in dendritic spines by Matus, Andrew, Fischer, Maria, Kaech, Stefanie, Wagner, Uta, Brinkhaus, Heike

“…Dendritic spines at excitatory synapses undergo rapid, actin-dependent shape changes which may contribute to plasticity in brain circuits. Here we show that…”
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Interactions between drebrin and Ras regulate dendritic spine plasticity by Biou, Virginie, Brinkhaus, Heike, Malenka, Robert C., Matus, Andrew

“…Dendritic spines are major sites of morphological plasticity in the CNS, but the molecular mechanisms that regulate their dynamics remain poorly understood…”
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Volatile Anesthetics Block Actin-Based Motility in Dendritic Spines by Kaech, Stefanie, Brinkhaus, Heike, Matus, Andrew

“…Dendritic spines form the postsynaptic contact sites for most excitatory synapses in the brain. Spines occur in a wide range of different shapes that can vary…”
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JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer by Britschgi, Adrian, Andraos, Rita, Brinkhaus, Heike, Klebba, Ina, Romanet, Vincent, Müller, Urs, Murakami, Masato, Radimerski, Thomas, Bentires-Alj, Mohamed

“…Hyperactive PI3K/mTOR signaling is prevalent in human malignancies and its inhibition has potent antitumor consequences. Unfortunately, single-agent targeted…”
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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Couto, Joana Pinto, Brinkhaus, Heike, Koren, Shany, De Silva, Duvini, Mertz, Kirsten D., Kaup, Daniela, Varga, Zsuzsanna, Voshol, Hans, Vissieres, Alexandra, Leroy, Cedric, Roloff, Tim, Stadler, Michael B., Scheel, Christina H., Miraglia, Loren J., Orth, Anthony P., Bonamy, Ghislain M. C., Reddy, Venkateshwar A., Bentires-Alj, Mohamed

“…Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby…”
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Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors by MEYER, Dominique S, BRINKHAUS, Heike, MÜLLER, Urs, MÜLLER, Matthias, CARDIFF, Robert D, BENTIRES-ALJ, Mohamed

“…The phosphoinositide 3-kinase (PI3K) signaling cascade, a key mediator of cellular survival, growth, and metabolism, is frequently altered in human cancer…”
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Early but not late pregnancy induces lifelong reductions in the proportion of mammary progesterone sensing cells and epithelial Wnt signaling by Meier-Abt, Fabienne, Brinkhaus, Heike, Bentires-Alj, Mohamed

“…Keywords: Mammary Gland, Early Pregnancy, Mammary Epithelial Cell, Late Pregnancy, Early Parity…”
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Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells by Duss, Stephan, Brinkhaus, Heike, Britschgi, Adrian, Cabuy, Erik, Frey, Daniel M, Schaefer, Dirk J, Bentires-Alj, Mohamed

“…Stromal-epithelial interactions play a fundamental role in tissue homeostasis, controlling cell proliferation and differentiation. Not surprisingly, aberrant…”
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Abstract 3305: Hippo kinases LATS1/2 control human breast cell fate by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Brinkhaus, Heike, Pinto Couto, Joana, De Silva, Duvini, Miraglia, Loren, Stadler, Michael B., Orth, Anthony P., Bonamy, Ghislain M.C., Reddy, Venkateshwar A., Bentires-Alj, Mohamed

“…Cellular differentiation and lineage commitment in adult tissues is a tightly regulated, yet highly dynamic process. It is of crucial importance to understand…”
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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ER by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Couto, Joana Pinto, Brinkhaus, Heike, Koren, Shany, De Silva, Duvini, Mertz, Kirsten D, Kaup, Daniela, Varga, Zsuzsanna, Voshol, Hans, Vissieres, Alexandra, Leroy, Cedric, Roloff, Tim, Stadler, Michael B, Scheel, Christina H, Miraglia, Loren J, Orth, Anthony P, Bonamy, Ghislain M. C, Reddy, Venkateshwar A, Bentires-Alj, Mohamed

“…Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-[alpha], thereby…”
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Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation by Milani, Emanuela S, Brinkhaus, Heike, Dueggeli, Regula, Klebba, Ina, Mueller, Urs, Stadler, Michael, Kohler, Hubertus, Smalley, Matthew J, Bentires-Alj, Mohamed

“…Tyrosine phosphorylation plays a fundamental role in mammary gland development. However, the role of specific tyrosine phosphatases in controlling mammary cell…”
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Abstract LB-36: JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: A rationale for co-targeting these pathways in metastatic breast cancer by Britschgi, Adrian, Andraos, Rita, Brinkhaus, Heike, Klebba, Inna, Murakami, Masato, Romanet, Vincent, Müller, Urs, Radimerski, Thomas, Bentires-Alj, Mohamed

“…Hyperactive PI3K/mTOR signaling is prevalent in the majority of human malignancies (1) and its inhibition exhibits potent antitumor activity in a wide spectrum…”
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Abstract LB-205: The calcium activated chloride channel ANO1 promotes breast cancer progression by activating EGFR- and CAMK-signaling by Britschgi, Adrian, Bill, Anke, Brinkhaus, Heike, Rothwell, Christopher, Clay, Ieuan, Duss, Stephan, Rebhan, Michael, Raman, Pichai, Guy, Chantale, Wetzel, Kristie, George, Elizabeth, Popa, M. Oana, Lilley, Sarah, Choudhury, Hedaythul, Gosling, Martin, Wang, Louis, Fitzgerald, Stephanie, Borawski, Jason, Baffoe, Jonathan, Labow, Mark, Gaither, L. Alex, Bentires-Alj, Mohamed

“…Genomic alterations are the underlining cause of many human cancers: Amplified and overexpressed genes can drive neoplastic transformation and become essential…”
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Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling by Britschgi, Adrian, Bill, Anke, Brinkhaus, Heike, Rothwell, Christopher, Clay, Ieuan, Duss, Stephan, Rebhan, Michael, Raman, Pichai, Guy, Chantale T., Wetzel, Kristie, George, Elizabeth, Popa, M. Oana, Lilley, Sarah, Choudhury, Hedaythul, Gosling, Martin, Wang, Louis, Fitzgerald, Stephanie, Borawski, Jason, Baffoe, Jonathan, Labow, Mark, Gaither, L. Alex, Bentires-Alj, Mohamed

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Actin dynamics in dendritic spines: A form of regulated plasticity at excitatory synapses by Matus, Andrew, Brinkhaus, Heike, Wagner, Uta

“…Dendritic spines form the postsynaptic element at most excitatory synapses in the brain. The spine cytoskeleton consists of actin filaments which, in…”
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Influx of extracellular calcium regulates actin-dependent morphological plasticity in dendritic spines by Brünig, Ina, Kaech, Stefanie, Brinkhaus, Heike, Oertner, Thomas G., Matus, Andrew

“…Dendritic spines contain a specialized cytoskeleton composed of dynamic actin filaments capable of producing rapid changes in their motility and morphology…”
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