Search Results - "BRINGUIER, P. P"

PTEN, ATM, IDH1 mutations and MAPK pathway activation as modulators of PFS and OS in patients treated by first line EGFR TKI, an ancillary study of the French Cooperative Thoracic Intergroup (IFCT) Biomarkers France project by Blons, H., Oudart, J.-B., Merlio, J.-P., Debieuvre, D., de Fraipont, F., Audigier-Valette, C., Escande, F., Hominal, S., Bringuier, P.‐P., Fraboulet-Moreau, S., Ouafik, L., Moro-Sibilot, D., Lemoine, A., Langlais, A, Missy, P., Morin, F., Souquet, P.-J., Barlesi, F., Cadranel, J., Beau‐Faller, M.

“…•Response to EGFR TKI is heterogeneous among patients with EGFR mutated NSCLC.•Routine use of NGS enables co-mutations detection that may impact response to…”
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A prospective epidemiological study of new incident GISTs during two consecutive years in Rhône Alpes region: incidence and molecular distribution of GIST in a European region by Cassier, P A, Ducimetière, F, Lurkin, A, Ranchère-Vince, D, Scoazec, J-Y, Bringuier, P-P, Decouvelaere, A-V, Méeus, P, Cellier, D, Blay, J-Y, Ray-Coquard, I

“…Background: Preliminary data indicate that the molecular epidemiology of localised gastrointestinal stromal tumour (GIST) may be different from that of…”
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Dermoscopic features in BRAF and NRAS primary cutaneous melanoma: association with peppering and blue‐white veil by Gouillon, L., Perier‐Muzet, M., Amini‐Adle, M., Poulalhon, N., Debarbieux, S., Boespflug, A., Balme, B., Depaepe, L., Harou, O., Lopez, J., Bringuier, P.‐P., Ferraro‐Peyret, C., Maucort‐Boulch, D., Robinson, P., Thomas, L., Dalle, S.

“…PURPOSE MYC rearrangement ( MYC-R) occurs in approximately 10% of diffuse large B-cell lymphomas (DLBCLs) and has been associated with poor prognosis in many…”
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Clinical and molecular characteristics of non-small-cell lung cancer (NSCLC) harboring EGFR mutation: results of the nationwide French Cooperative Thoracic Intergroup (IFCT) program by Leduc, C., Merlio, J.P., Besse, B., Blons, H., Debieuvre, D., Bringuier, P.P., Monnet, I., Rouquette, I., Fraboulet-Moreau, S., Lemoine, A., Pouessel, D., Mosser, J., Vaylet, F., Langlais, A., Missy, P., Morin, F., Moro-Sibilot, D., Cadranel, J., Barlesi, F., Beau-Faller, M.

“…EGFR mutations cause inconsistent response to EGFR tyrosine-kinase inhibitors (TKI). To better understand these features, we reviewed all cases of EGFR-mutated…”
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Uncommon EGFR mutations in lung adenocarcinomas: Clinical features and response to tyrosine kinase inhibitors by Brindel, A., Althakfi, W., Barritault, M., Bringuier, P.-P., Watkin, E., Maury, J.-M., Girard, N., Brevet, M.

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Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs by Emile, J. F., Brahimi, S., Coindre, J. M., Bringuier, P. P., Monges, G., Samb, P., Doucet, L., Hostein, I., Landi, B., Buisine, M. P., Neuville, A., Bouché, O., Cervera, P., Pretet, J. L., Tisserand, J., Gauthier, A., Le Cesne, A., Sabourin, J. C., Scoazec, J. Y., Bonvalot, S., Corless, C. L., Heinrich, M. C., Blay, J. Y., Aegerter, P.

“…Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma. Most of the data available on GISTs derive from retrospective studies of patients…”
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Molecular heterogeneity assessment by NGS in non-small cell lung cancer (NSCLC) harboring EGFR mutations: Results of the French Cooperative Thoracic Intergroup (IFCT) Biomarkers France study by Blons, H., Oudart, J.-B., Merlio, J.-P., Hominal, S., de Fraipont, F., Debieuvre, D., Escande, F., Audigier Valette, C., Bringuier, P.-P., Moreau Fraboulet, S., Ouafik, L., Moro-Sibilot, D., Lemoine, A., Langlais, A., Missy, P., Morin, F., Souquet, P.-J., Barlesi, F., Cadranel, J., Beau-Faller, M.

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Comment on: ‘COUP-TFII regulates metastasis of colorectal adenocarcinoma cells by modulating Snail1’ by Bringuier, P-P, Giroldi, L A

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Identification of biological factors predictive of response to imatinib mesylate in aggressive fibromatosis by Dufresne, A, Bertucci, F, Penel, N, Le Cesne, A, Bui, B, Tubiana-Hulin, M, Ray-Coquard, I, Cupissol, D, Chevreau, C, Perol, D, Goncalves, A, Jimenez, M, Bringuier, P P, Blay, J Y

“…Background: Imatinib induces responses and disease stabilisations in non-resectable patients with aggressive fibromatosis (AF). The precise target of imatinib…”
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Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer by UMBAS, R, ISAACS, W. B, BRINGUIER, P. P, SCHAAFSMA, H. E, KARTHAUS, H. F. M, OOSTERHOF, G. O. N, DEBRUYNE, F. M. J, SCHALKEN, J. A

“…Decreased levels of the cell-cell adhesion molecule E-cadherin are associated with loss of differentiation in a number of human carcinomas. However, the value…”
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Expression of β-catenin in gastroenteropancreatic endocrine tumours: a study of 229 cases by Hervieu, V, Lepinasse, F, Gouysse, G, Guillaud, O, Barel, C, Chambonniere, M-L, Bringuier, P-P, Poncet, G, Lombard-Bohas, C, Partensky, C, Chayvialle, J-A, Scoazec, J-Y

“…Aims: To clarify the role of β-catenin in digestive endocrine carcinogenesis, a large and representative series of gastroenteropancreatic endocrine tumours was…”
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Expression of cyclin D1 and EMS1 in bladder tumours; relationship with chromosome 11q13 amplification by Bringuier, P P, Tamimi, Y, Schuuring, E, Schalken, J

“…11q13 amplifications have been found in several cancers, including bladder tumours. However, the biological significance of this genetic alteration is not yet…”
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Prognostic value of cadherin-associated molecules (α-, β-, and γ-catenins and p120ras) in bladder tumors by SHIMAZUI, R, SCHALKEN, J. A, JANSEN, C. F. J, AKAZA, H, KOISO, K, DEBRUYNE, F. M. J, BRINGUIER, P. P, GIROLDI, L. A

“…Loss of E-cadherin-mediated adhesion is an important step in the progression of many carcinomas. In model systems, it has been shown that cadherin function…”
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Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors by BRINGUIER, P. P, UMBAS, R, SCHAAFSMA, H. E, KARTHAUS, H. F. M, DEBRUYNE, F. M. J, SCHALKEN, J. A

“…E-cadherin, an intercellular adhesion molecule, has been shown to behave like an invasion suppressor gene in vitro. This may explain the inverse relation…”
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Incidence rate, epidemiology of sarcoma and molecular biology. Preliminary results from EMS study in the Rhône-Alpes region by Ducimetière, F, Lurkin, A, Ranchère-Vince, D, Decouvelaere, A-V, Isaac, S, Claret-Tournier, C, Suignard, Y, Salameire, D, Cellier, D, Alberti, L, Bringuier, P-P, Blay, J-Y, Ray-Coquard, I

“…Sarcomas comprise a heterogeneous group of mesenchymal neoplasms. They can be grouped into 3 general categories, soft tissue sarcoma, visceral and primary bone…”
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Detection of chromosomal imbalances in transitional cell carcinoma of the bladder by comparative genomic hybridization by Voorter, C, Joos, S, Bringuier, PP, Vallinga, M, Poddighe, P, Schalken, J, du Manoir, S, Ramaekers, F, Lichter, P, Hopman, A

“…Comparative genomic hybridization (CGH) was applied for a comprehensive screening of chromosomal aberrations in 14 transitional cell carcinomas of the bladder…”
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Relation between aberrant α‐catenin expression and loss of E‐cadherin function in prostate cancer by Umbas, Rainy, Isaacs, William B., Bringuier, Pierre Paul, Xue, Yong, Debruyne, Frans M.J., Schalken, Jack A.

“…It is now well documented that E‐cadherin expression correlates inversely with tumor grade in various carcinomas including prostate cancer. We also…”
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Changes in cadherin‐catenin complexes in the progression of human bladder carcinoma by Giroldi, Laurence A., Bringuier, Pierre‐Paul, Shimazui, Toru, Jansen, Kees, Schalken, Jack A.

“…We are investigating the hypothesis that cancer progression involves the formation of abnormal cadherin‐catenin complexes. The detailed analysis of cadherins…”
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Astrocytomas and Choroid Plexus Tumors in Two Families with Identical p53 Germline Mutations by Vital, Anne, Bringuier, Pierre-Paul, Huang, Huatao, Galli, François San, Rivel, Janine, Ansoborlo, Sophie, Cazauran, Jean-Marie, Taillandier, Luc, Kleihues, Paul, Ohgaki, Hiroko

“…Germline p53 mutations carry an increased risk of development of breast cancer, soft tissue and osteosarcomas, brain tumors, leukemia and adrenocortical…”
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Carcinomas of the renal pelvis associated with smoking and phenacetin abuse: p53 mutations and polymorphism of carcinogen‐metabolising enzymes by Bringuier, Pierre‐Paul, McCredie, Margaret, Sauter, Guido, Bilous, Michael, Stewart, John, Mihatsch, Michael J., Kleihues, Paul, Ohgaki, Hiroko

“…Phenacetin abuse and smoking are established risk factors for transitional cell carcinomas of the urinary tract. In the present study, we analysed exposure and…”
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