Search Results - "BRILL, Emma R"

Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-pyrrolidinones-stereochemical and lower side-chain optimization by ELWORTHY, Todd R, KERTESZ, Denis J, LACH, Leang K, MCGEE, Daren, YANG, Diana S, CHIOU, San-San, WOONGKI KIM, ROEPEL, Michael G, QUATTROCCHIO-SETTI, Lina, SMITH, David B, TRACY, Jahari Laurant, CHOW, Audrey, FUJUN LI, BRILL, Emma R

“…A series of 7-[(5R)-substituted 2-oxo-1-pyrrolidinyl]-heptanoic acids were prepared, their isomeric purity determined, and pharmacologically evaluated. Lactams…”
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Lactams as EP4 Prostanoid Receptor Agonists. 3. Discovery of N-Ethylbenzoic Acid 2-Pyrrolidinones as Subtype Selective Agents by Elworthy, Todd R, Brill, Emma R, Chiou, San-San, Chu, Frances, Harris, Jason R, Hendricks, R. Than, Huang, Jane, Kim, Woongki, Lach, Leang K, Mirzadegan, Tara, Yee, Calvin, Walker, Keith A. M

“…Two distinct synthetic schemes were applied to access heteroatom-containing α-chain lactams or lactams terminated as aryl acids. The latter lactams were…”
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Lactams as prostanoid receptor ligands. Part 4: 2-Piperidones as selective EP4 receptor agonists by Elworthy, Todd R., Brill, Emma R., Caires, Christopher C., Kim, Woongki, Lach, Leang K., Tracy, Jahari Laurant, Chiou, San-San

“…2-Piperidones were prepared bearing heptanoic acid or a thioether heptanoic acid at the 1-position and appropriately substituted at the 6-position to mimic the…”
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Lactams as EP 4 Prostanoid Receptor Agonists. 3. Discovery of N -Ethylbenzoic Acid 2-Pyrrolidinones as Subtype Selective Agents by Elworthy, Todd R., Brill, Emma R., Chiou, San-San, Chu, Frances, Harris, Jason R., Hendricks, R. Than, Huang, Jane, Kim, Woongki, Lach, Leang K., Mirzadegan, Tara, Yee, Calvin, Walker, Keith A. M.

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Lactams as EP 4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization by Elworthy, Todd R., Kertesz, Denis J., Kim, Woongki, Roepel, Michael G., Quattrocchio-Setti, Lina, Smith, David B., Tracy, Jahari Laurant, Chow, Audrey, Li, Fujun, Brill, Emma R., Lach, Leang K., McGee, Daren, Yang, Diana S., Chiou, San-San

“…A series of 7-[(5 R)-substituted 2-oxo-1-pyrrolidinyl]-heptanoic acids were prepared, their isomeric purity determined, and pharmacologically evaluated…”
Get full text