Search Results - "BRIJESH KUMAR SRIVASTAVA"

Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B0AT1 (SLC6A19) by Desai, Jigar, Patel, Bhaumin, Darji, Brijesh, Gite, Archana, Panchal, Nandini, Bhosale, Gokul, Shedage, Sandeep, Patel, Sandip, Kadam, Pravin, Patel, Gautam, Kumar Srivastava, Brijesh, Joharapurkar, Amit, Kshirsagar, Samadhan, Giri, Poonam, Bhayani, Hitesh, Patel, Ankit, Ghoshdastidar, Krishnarup, Bandyopadhyay, Debdutta, Kumar, Sanjay, Jain, Mukul, Sharma, Rajiv

“…[Display omitted] •Inhibition of neutral amino acid transporter B0AT1 (SLC6A19) activity has been recently identified as promising strategy to treat type 2…”
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Diaryl Dihydropyrazole-3-carboxamides with Significant In Vivo Antiobesity Activity Related to CB1 Receptor Antagonism:  Synthesis, Biological Evaluation, and Molecular Modeling in the Homology Model by Joharapurkar, Amit, Raval, Saurin, Patel, Jayendra Z, Soni, Rina, Raval, Preeti, Gite, Archana, Goswami, Amitgiri, Sadhwani, Nisha, Gandhi, Neha, Patel, Harilal, Mishra, Bhupendra, Solanki, Manish, Pandey, Bipin, Jain, Mukul R, Patel, Pankaj R

“…A number of analogues of diaryl dihydropyrazole-3-carboxamides have been synthesized. Their activities were evaluated for appetite suppression and body weight…”
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Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2- c]pyridine quinolones by Srivastava, Brijesh Kumar, Solanki, Manish, Mishra, Bhupendra, Soni, Rina, Jayadev, Sanjaya, Valani, Darshan, Jain, Mukul, Patel, Pankaj R.

“…Synthesis and antibacterial activity of a number of substituted 4,5,6,7-tetrahydro-thieno[3,2- c]pyridine quinolones is reported. The antibacterial activities…”
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3D QSAR studies of N-4-arylacryloylpiperazin-1-yl-phenyl-oxazolidinones: A novel class of antibacterial agents by Lohray, B.B., Gandhi, Neha, Srivastava, Brijesh Kumar, Lohray, Vidya Bhushan

“…Three-dimensional QSAR studies for N-4-arylacryloylpiperazin-1-yl-phenyl-oxazolidinones were conducted using TSAR 3.3. The in vitro activities (MICs) of the…”
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Synthesis and in vitro antibacterial activities of novel oxazolidinones by Srivastava, Brijesh Kumar, Jain, Mukul R., Solanki, Manish, Soni, Rina, Valani, Darshan, Gupta, Sunil, Mishra, Bhupendra, Takale, Vijay, Kapadnis, Prashant, Patel, Harilal, Pandya, Purvi, Patel, Jayendra Z., Patel, Pankaj R.

“…Design and synthesis of novel piperazinylaryloxazolidinones possessing heteroaryl groups are described and their in vitro antibacterial activities have been…”
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Novel tetrahydro-thieno pyridyl oxazolidinone: an antibacterial agent by Lohray, Braj Bhushan, Lohray, Vidya Bhushan, Srivastava, Brijesh Kumar, Kapadnis, Prashant B., Pandya, Purvi

“…We have synthesized and evaluated antibacterial activity of a number of 4,5,6,7-tetrahydro-thieno[3,2- c]pyridine substituted oxazolidinones against several…”
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Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials by Lohray, Braj Bhushan, Lohray, Vidya Bhushan, Srivastava, Brijesh Kumar, Gupta, Sunil, Solanki, Manish, Pandya, Purvi, Kapadnis, Prashant

“…A few substituted piperazinylphenyloxazolidinone compounds 6–13 having substitution on the distant nitrogen atom of piperazine ring scaffold have been…”
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Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist by Kumar Srivastava, Brijesh, Soni, Rina, Patel, Jayendra Z, Jha, Satadru, Shedage, Sandeep A, Gandhi, Neha, Sairam, Kalapatapu V V M, Pawar, Vishwanath, Sadhwani, Nisha, Mitra, Prasenjit, Jain, Mukul R, Patel, Pankaj R

“…Facile synthesis of biaryl pyrazole sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid…”
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Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones by Srivastava, Brijesh Kumar, Soni, Rina, Patel, Jayendra Z., Solanki, Manish, Valani, Darshan, Gupta, Sunil, Mishra, Bhupendra, Takale, Vijay, Pandya, Purvi, Jain, Mukul R., Patel, Pankaj R.

“…Design and synthesis of a few novel methylamino piperidinyl substituted oxazolidinones are reported and their antibacterial activities have been evaluated in…”
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Oxazolidinone: search for highly potent antibacterial by Lohray, Braj Bhushan, Lohray, Vidya Bhushan, Srivastava, Brijesh Kumar, Gupta, Sunil, Solanki, Manish, Kapadnis, Prashant, Takale, Vijay, Pandya, Purvi

“…A number of substituted piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activities were evaluated. A systematic SAR was…”
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Novel Mannich ketones of oxazolidinones as antibacterial agents by Srivastava, Brijesh Kumar, Kapadnis, Prashant B., Pandya, Purvi, Lohray, Vidya Bhushan

“…A few Mannich ketones of piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activity in various Gram-positive organisms such…”
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ZYDG2, a Potent, Selective, and Safe GPR40 Agonist for Treatment of Type 2 Diabetes by JAIN, MUKUL R., GIRI, SURESH R., TRIVEDI, CHITRANG J., BHOI, BIBHUTI B., RATH, AKSHYAYA CHANDAN, RATHOD, ROHAN MANUBHAI, SUNDAR, RAJESH, BANDYOPADHYAY, DEBDUTTA, RAMDHAVE, RASHMI, PATEL, GAUTAM D., SRIVASTAVA, BRIJESH KUMAR, DESAI, RANJIT C.

“…GPR40 is a G-protein-coupled receptor predominantly expressed in pancreatic β-cells. Agonists of GPR40 are known to stimulate insulin secretion and reduces…”
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Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1 by Jain, Mukul R., Mohapatra, Jogeswar, Bandhyopadhyay, Debdutta, Chatterjee, Abhijit, Ghoshdastidar, Krishnarup, Patel, Dinesh, Patel, Ankit, Bhayani, Hitesh, Srivastava, Brijesh Kumar, Shedage, Sandeep A., Kadam, Pravin, Sundar, Rajesh, Patel, Harilal, Giri, Poonam, Patel, Prakash, Gupta, Laxmikant, Srinivas, Nuggehally R., Patel, Pankaj R., Desai, Ranjit C.

“…Purpose Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in the detection and repair of DNA damage. Studies have shown that inhibition of…”
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Cannabinoid receptor 1 antagonist treatment induces glucagon release and shows an additive therapeutic effect with GLP-1 agonist in diet-induced obese mice by Patel, Kartikkumar Navinchandra, Joharapurkar, Amit Arvind, Patel, Vishal, Kshirsagar, Samadhan Govind, Bahekar, Rajesh, Srivastava, Brijesh Kumar, Jain, Mukul R

“…Cannabinoid 1 (CB1) receptor antagonists reduce body weight and improve insulin sensitivity. Preclinical data indicates that an acute dose of CB1 antagonist…”
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Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B 0 AT1 (SLC6A19) by Desai, Jigar, Patel, Bhaumin, Darji, Brijesh, Gite, Archana, Panchal, Nandini, Bhosale, Gokul, Shedage, Sandeep, Patel, Sandip, Kadam, Pravin, Patel, Gautam, Kumar Srivastava, Brijesh, Joharapurkar, Amit, Kshirsagar, Samadhan, Giri, Poonam, Bhayani, Hitesh, Patel, Ankit, Ghoshdastidar, Krishnarup, Bandyopadhyay, Debdutta, Kumar, Sanjay, Jain, Mukul, Sharma, Rajiv

“…Amino acid restriction by inhibition of neutral amino acid transporter, B AT1 (SLC6A19) activity has been recently shown to improve glyceamic control by…”
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Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a cb1 receptor antagonist with in vivo antiobesity effect by Srivastava, Brijesh Kumar, Soni, Rina, Patel, Jayendra Z., Joharapurkar, Amit, Sadhwani, Nisha, Kshirsagar, Samadhan, Mishra, Bhupendra, Takale, Vijay, Gupta, Sunil, Pandya, Purvi, Kapadnis, Prashant, Solanki, Manish, Patel, Harilal, Mitra, Prasenjit, Jain, Mukul R., Patel, Pankaj R.

“…A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as…”
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Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a cbl receptor antagonist with in vivo antiobesity effect by BRIJESH KUMAR SRIVASTAVA, SONI, Rina, KAPADNIS, Prashant, SOLANKI, Manish, PATEL, Harilal, MITRA, Prasenjit, JAIN, Mukul R, PATEL, Pankaj R, PATEL, Jayendra Z, JOHARAPURKAR, Amit, SADHWANI, Nisha, KSHIRSAGAR, Samadhan, MISHRA, Bhupendra, TAKALE, Vijay, GUPTA, Sunil, PANDYA, Purvi

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Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole by Srivastava, Brijesh Kumar, Soni, Rina, Joharapurkar, Amit, Sairam, Kalapatapu V V M, Patel, Jayendra Z, Goswami, Amitgiri, Shedage, Sandeep A, Kar, Sidhartha S, Salunke, Rahul P, Gugale, Shivaji B, Dhawas, Amol, Kadam, Pravin, Mishra, Bhupendra, Sadhwani, Nisha, Unadkat, Vishal B, Mitra, Prasenjit, Jain, Mukul R, Patel, Pankaj R

“…Design, synthesis and conformational analysis of few imidazole and oxazole as bioisosters of…”
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Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-l-(2.4-dichlorophenyl)-4-methyl-lH-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist by BRIJESH KUMAR SRIVASTAVA, SONI, Rina, JAIN, Mukul R, PATEL, Pankaj R, PATEL, Jayendra Z, JHA, Satadru, SHEDAGE, Sandeep A, GANDHI, Neha, SAIRAM, Kalapatapu V. V. M, PAWAR, Vishwanath, SADHWANI, Nisha, MITRA, Prasenjit

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Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H-pyrazole-3-carboxylic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist by Kumar Srivastava, Brijesh, Soni, Rina, Patel, Jayendra Z., Jha, Satadru, Shedage, Sandeep A., Gandhi, Neha, Sairam, Kalapatapu V.V.M., Pawar, Vishwanath, Sadhwani, Nisha, Mitra, Prasenjit, Jain, Mukul R., Patel, Pankaj R.

“…Facile synthesis of biaryl pyrazole sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H-pyrazole-3-carboxylic acid…”
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