Search Results - "BRIERLEY, Stuart M"

Pain in Endometriosis by Maddern, Jessica, Grundy, Luke, Castro, Joel, Brierley, Stuart M.

“…Endometriosis is a chronic and debilitating condition affecting ~10% of women. Endometriosis is characterized by infertility and chronic pelvic pain, yet…”
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Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome by Grundy, Luke, Caldwell, Ashlee, Brierley, Stuart M

“…The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal cord, providing sensory input to the micturition centers…”
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Neuroplasticity and dysfunction after gastrointestinal inflammation by Brierley, Stuart M., Linden, David R.

“…Key Points Gastrointestinal infection and inflammation are key risk factors for the development of numerous clinical gastrointestinal disorders that present…”
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Colonic afferent input and dorsal horn neuron activation differs between the thoracolumbar and lumbosacral spinal cord by Harrington, Andrea M, Caraballo, Sonia Garcia, Maddern, Jessica E, Grundy, Luke, Castro, Joel, Brierley, Stuart M

“…The distal colon is innervated by the splanchnic and pelvic nerves, which relay into the thoracolumbar and lumbosacral spinal cord, respectively. Although the…”
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Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate by Castro, Joel, Harrington, Andrea M, Hughes, Patrick A, Martin, Christopher M, Ge, Pei, Shea, Courtney M, Jin, Hong, Jacobson, Sarah, Hannig, Gerhard, Mann, Elizabeth, Cohen, Mitchell B, MacDougall, James E, Lavins, Bernard J, Kurtz, Caroline B, Silos-Santiago, Inmaculada, Johnston, Jeffrey M, Currie, Mark G, Blackshaw, L. Ashley, Brierley, Stuart M

“…Background & Aims Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel…”
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Protease-activated receptor 1 is implicated in irritable bowel syndrome mediators–induced signaling to thoracic human sensory neurons by Desormeaux, Cleo, Bautzova, Tereza, Garcia-Caraballo, Sonia, Rolland, Corinne, Barbaro, Maria Raffaella, Brierley, Stuart M., Barbara, Giovanni, Vergnolle, Nathalie, Cenac, Nicolas

“…Proteases and protease-activated receptors (PARs) are major mediators involved in irritable bowel syndrome (IBS). Our objectives were to decipher the…”
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Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice by Grundy, Luke, Harrington, Andrea M., Caldwell, Ashlee, Castro, Joel, Staikopoulos, Vasiliki, Zagorodnyuk, Vladimir P., Brookes, Simon J.H., Spencer, Nick J., Brierley, Stuart M.

“…Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic…”
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Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice by Spencer, Nick J., Greenheigh, Sarah, Kyloh, Melinda, Hibberd, Tim J., Sharma, Harman, Grundy, Luke, Brierley, Stuart M., Harrington, Andrea M., Beckett, Elizabeth A., Brookes, Simon J., Zagorodnyuk, Vladimir P.

“…Spinal afferent neurons are responsible for the transduction and transmission of noxious (painful) stimuli and innocuous stimuli that do not reach conscious…”
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The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli by Brierley, Stuart M, Hughes, Patrick A, Page, Amanda J, Kwan, Kelvin Y, Martin, Christopher M, O'Donnell, Tracey A, Cooper, Nicole J, Harrington, Andrea M, Adam, Birgit, Liebregts, Tobias, Holtmann, Gerald, Corey, David P, Rychkov, Grigori Y, Blackshaw, L. Ashley

“…Background & Aims The transient receptor potential (TRP) channel family includes transducers of mechanical and chemical stimuli for visceral sensory neurons…”
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TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity by Brierley, Stuart M., Castro, Joel, Harrington, Andrea M., Hughes, Patrick A., Page, Amanda J., Rychkov, Grigori Y., Blackshaw, L. Ashley

“…Non‐technical summary  Detecting mechanical stimuli is vital to determining our responses to environmental challenges. The speed required for this process…”
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TGR5 agonists induce peripheral and central hypersensitivity to bladder distension by Caldwell, Ashlee, Grundy, Luke, Harrington, Andrea M., Garcia-Caraballo, Sonia, Castro, Joel, Bunnett, Nigel W., Brierley, Stuart M.

“…The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are…”
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Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology by Jami, Sina, Erickson, Andelain, Brierley, Stuart M, Vetter, Irina

“…Venoms are produced by a wide variety of species including spiders, scorpions, reptiles, cnidarians, and fish for the purpose of harming or incapacitating…”
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Experimentally Induced Bladder Permeability Evokes Bladder Afferent Hypersensitivity in the Absence of Inflammation by Grundy, Luke, Caldwell, Ashlee, Lumsden, Amanda, Mohammadi, Ehsan, Hannig, Gerhard, Greenwood Van-Meervald, Beverley, Brierley, Stuart M.

“…Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urological condition charactersied by urinary urgency, frequency and pelvic pain, that…”
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Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways by Brierley, Stuart M, Page, Amanda J, Hughes, Patrick A, Adam, Birgit, Liebregts, Tobias, Cooper, Nicole J, Holtmann, Gerald, Liedtke, Wolfgang, Blackshaw, L. Ashley

“…Background & Aims: Although there are many candidates as molecular mechanotransducers, so far there has been no evidence for molecular specialization of…”
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G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease by Lee, Ming-Chin, McCubbin, James A, Christensen, Anne D, Poole, Daniel P, Rajasekhar, Pradeep, Lieu, TinaMarie, Bunnett, Nigel W, Garcia-Caraballo, Sonia, Erickson, Andelain, Brierley, Stuart M, Saleh, Reem, Achuthan, Adrian, Fleetwood, Andrew J, Anderson, Robin L, Hamilton, John A, Cook, Andrew D

“…G-CSF or CSF-3, originally defined as a regulator of granulocyte lineage development via its cell surface receptor (G-CSFR), can play a role in inflammation,…”
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Gastric vagal afferent modulation by leptin is influenced by food intake status by Kentish, Stephen J., O'Donnell, Tracey A., Isaacs, Nicole J., Young, Richard L., Li, Hui, Harrington, Andrea M., Brierley, Stuart M., Wittert, Gary A., Blackshaw, L. Ashley, Page, Amanda J.

“…Key points •  Obesity occurs when energy intake exceeds expenditure, and the excess energy is stored as fat. •  We show that, after a 14 h food deprivation or…”
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Spinal Afferent Innervation of the Colon and Rectum by Brierley, Stuart M, Hibberd, Timothy J, Spencer, Nick J

“…Despite their seemingly elementary roles, the colon and rectum undertake a variety of key processes to ensure our overall wellbeing. Such processes are…”
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Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice by Brierley, Stuart M., Jones, R.Carter W., Gebhart, Gerald F., Blackshaw, L.Ashley

“…Background&Aims: Mechanosensory information from the colon is conducted via lumbar splanchnic nerves (LSN) and sacral pelvic nerves (PN) to the spinal cord…”
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Identification of a Quorum Sensing-Dependent Communication Pathway Mediating Bacteria-Gut-Brain Cross Talk by Uhlig, Friederike, Grundy, Luke, Garcia-Caraballo, Sonia, Brierley, Stuart M., Foster, Simon J., Grundy, David

“…Despite recently established contributions of the intestinal microbiome to human health and disease, our understanding of bacteria-host communication pathways…”
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Clodronate Treatment Prevents Vaginal Hypersensitivity in a Mouse Model of Vestibulodynia by Castro, Joel, Harrington, Andrea M, Chegini, Fariba, Matusica, Dusan, Spencer, Nick J, Brierley, Stuart M, Haberberger, Rainer V, Barry, Christine M

“…Improved understanding of vestibulodynia pathophysiology is required to develop appropriately targeted treatments. Established features include vulvovaginal…”
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