Search Results - "BRICE, E"

Stem cells: Aging and transcriptional fingerprints by Keyes, Brice E, Fuchs, Elaine

“…Stem cells are imbued with unique qualities. They have the capacity to propagate themselves through symmetric divisions and to divide asymmetrically to…”
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Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision by Lu, Catherine P., Polak, Lisa, Keyes, Brice E., Fuchs, Elaine

“…The gain of eccrine sweat glands in hairy body skin has empowered humans to run marathons and tolerate temperature extremes. Epithelial-mesenchymal cross-talk…”
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Amphotericin primarily kills yeast by simply binding ergosterol by Gray, Kaitlyn C., Palacios, Daniel S., Dailey, Ian, Endo, Matthew M., Uno, Brice E., Wilcock, Brandon C., Burke, Martin D.

“…Amphotericin B (AmB) is a prototypical small molecule natural product that can form ion channels in living eukaryotic cells and has remained refractory to…”
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BMP Signaling and Its pSMAD1/5 Target Genes Differentially Regulate Hair Follicle Stem Cell Lineages by Genander, Maria, Cook, Peter J., Ramsköld, Daniel, Keyes, Brice E., Mertz, Aaron F., Sandberg, Rickard, Fuchs, Elaine

“…Hair follicle stem cells (HFSCs) and their transit amplifying cell (TAC) progeny sense BMPs at defined stages of the hair cycle to control their proliferation…”
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Amphotericin forms an extramembranous and fungicidal sterol sponge by Anderson, Thomas M, Clay, Mary C, Cioffi, Alexander G, Diaz, Katrina A, Hisao, Grant S, Tuttle, Marcus D, Nieuwkoop, Andrew J, Comellas, Gemma, Maryum, Nashrah, Wang, Shu, Uno, Brice E, Wildeman, Erin L, Gonen, Tamir, Rienstra, Chad M, Burke, Martin D

“…NMR structural data and biophysical and biological experiments show that the antifungal compound amphotericin is toxic because it acts as a sterol sponge by…”
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RNAi screens in mice identify physiological regulators of oncogenic growth by Beronja, Slobodan, Janki, Peter, Heller, Evan, Lien, Wen-Hui, Keyes, Brice E., Oshimori, Naoki, Fuchs, Elaine

“…Tissue growth is the multifaceted outcome of a cell’s intrinsic capabilities and its interactions with the surrounding environment. Decoding these complexities…”
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Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin by Keyes, Brice E., Liu, Siqi, Asare, Amma, Naik, Shruti, Levorse, John, Polak, Lisa, Lu, Catherine P., Nikolova, Maria, Pasolli, Hilda Amalia, Fuchs, Elaine

“…Aged skin heals wounds poorly, increasing susceptibility to infections. Restoring homeostasis after wounding requires the coordinated actions of epidermal and…”
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SOX9: a stem cell transcriptional regulator of secreted niche signaling factors by Kadaja, Meelis, Keyes, Brice E, Lin, Mingyan, Pasolli, H Amalia, Genander, Maria, Polak, Lisa, Stokes, Nicole, Zheng, Deyou, Fuchs, Elaine

“…Hair follicles (HFs) undergo cyclical periods of growth, which are fueled by stem cells (SCs) at the base of the resting follicle. HF-SC formation occurs…”
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Nfatc1 orchestrates aging in hair follicle stem cells by Keyes, Brice E, Segal, Jeremy P, Heller, Evan, Lien, Wen-Hui, Chang, Chiung-Ying, Guo, Xingyi, Oristian, Dan S, Zheng, Deyou, Fuchs, Elaine

“…Hair production is fueled by stem cells (SCs), which transition between cyclical bouts of rest and activity. Here, we explore why hair growth wanes with age…”
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Infrasound signals in simulated nontornadic and pre-tornadic supercells by Coffer, Brice E., Parker, Matthew D.

“…There has been increased interest in improving severe weather detection by supplementing the conventional operational radar network with an infrasound…”
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Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer by Mondal, Tanmoy, Gaur, Himanshu, Wamba, Brice E. N., Michalak, Abby Grace, Stout, Camryn, Watson, Matthew R., Aleixo, Sophia L., Singh, Arjun, Condello, Salvatore, Faller, Roland, Leiserowitz, Gary Scott, Bhatnagar, Sanchita, Tushir-Singh, Jogender

“…Receptor clustering is the most critical step to activate extrinsic apoptosis by death receptors belonging to the TNF superfamily. Although clinically…”
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Combined Effects of Carbonate and Soft-Segment Molecular Structures on the Nanophase Separation and Properties of Segmented Polyhydroxyurethane by Beniah, Goliath, Chen, Xi, Uno, Brice E, Liu, Kun, Leitsch, Emily K, Jeon, Junho, Heath, William H, Scheidt, Karl A, Torkelson, John M

“…The influence of hard-segment structure on the properties of segmented polyhydroxy­urethane (PHU) was investigated using three bis-carbonate molecules:…”
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Tuning nanophase separation behavior in segmented polyhydroxyurethane via judicious choice of soft segment by Beniah, Goliath, Uno, Brice E., Lan, Tian, Jeon, Junho, Heath, William H., Scheidt, Karl A., Torkelson, John M.

“…Polyhydroxyurethane (PHU) is of major research interest because it is a non-isocyanate polyurethane-like (NIPU) polymer. Here, we demonstrate the ability to…”
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ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas by Yang, Hanseul, Schramek, Daniel, Adam, Rene C, Keyes, Brice E, Wang, Ping, Zheng, Deyou, Fuchs, Elaine

“…Tumor-initiating stem cells (SCs) exhibit distinct patterns of transcription factors and gene expression compared to healthy counterparts. Here, we show that…”
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Evidence for autophagy-dependent pathways of rRNA turnover in Arabidopsis by Floyd, Brice E, Morriss, Stephanie C, MacIntosh, Gustavo C, Bassham, Diane C

“…Ribosomes account for a majority of the cell's RNA and much of its protein and represent a significant investment of cellular resources. The turnover and…”
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C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells by Wilcock, Brandon C, Endo, Matthew M, Uno, Brice E, Burke, Martin D

“…Amphotericin B (AmB) is a clinically vital antimycotic but is limited by its severe toxicity. Binding ergosterol, independent of channel formation, is the…”
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Localization of RNS2 ribonuclease to the vacuole is required for its role in cellular homeostasis by Floyd, Brice E., Mugume, Yosia, Morriss, Stephanie C., MacIntosh, Gustavo C., Bassham, Diane C.

“…RNase T2 ribonucleases are highly conserved enzymes present in the genomes of nearly all eukaryotes and many microorganisms. Their constitutive expression in…”
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Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice by Chen, Zhenghao, Raj, Anil, Prateek, G V, Di Francesco, Andrea, Liu, Justin, Keyes, Brice E, Kolumam, Ganesh, Jojic, Vladimir, Freund, Adam

“…Behavior and physiology are essential readouts in many studies but have not benefited from the high-dimensional data revolution that has transformed molecular…”
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Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal by Maji, Arun, Soutar, Corinne P., Zhang, Jiabao, Lewandowska, Agnieszka, Uno, Brice E., Yan, Su, Shelke, Yogesh, Murhade, Ganesh, Nimerovsky, Evgeny, Borcik, Collin G., Arango, Andres S., Lange, Justin D., Marin-Toledo, Jonnathan P., Lyu, Yinghuan, Bailey, Keith L., Roady, Patrick J., Holler, Jordan T., Khandelwal, Anuj, SantaMaria, Anna M., Sanchez, Hiram, Juvvadi, Praveen R., Johns, Gina, Hageman, Michael J., Krise, Joanna, Gebremariam, Teclegiorgis, Youssef, Eman G., Bartizal, Ken, Marr, Kieren A., Steinbach, William J., Ibrahim, Ashraf S., Patterson, Thomas F., Wiederhold, Nathan P., Andes, David R., Pogorelov, Taras V., Schwieters, Charles D., Fan, Timothy M., Rienstra, Chad M., Burke, Martin D.

“…Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model 1 . Recently, the…”
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Botanicals and phytochemicals from the bark of Hypericum roeperianum (Hypericaceae) had strong antibacterial activity and showed synergistic effects with antibiotics against multidrug-resistant bacteria expressing active efflux pumps by Demgne, Olive Monique F., Damen, Francois, Fankam, Aimé G., Guefack, Michel-Gael F., Wamba, Brice E.N., Nayim, Paul, Mbaveng, Armelle T., Bitchagno, Gabin T.M., Tapondjou, Léon Azefack, Penlap, Veronique B., Tane, Pierre, Efferth, Thomas, Kuete, Victor

“…Infections due to multidrug-resistant (MDR) bacteria constitute a real problem in the public health worldwide. Hypericum roeperianum Schimp. ex A. Rich…”
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