Search Results - "BREWER, JAMES"

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion by Oliphant, Christopher J., Hwang, You Yi, Walker, Jennifer A., Salimi, Maryam, Wong, See Heng, Brewer, James M., Englezakis, Alexandros, Barlow, Jillian L., Hams, Emily, Scanlon, Seth T., Ogg, Graham S., Fallon, Padraic G., McKenzie, Andrew N.J.

“…Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and…”
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Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial by Craft, Suzanne, Raman, Rema, Chow, Tiffany W, Rafii, Michael S, Sun, Chung-Kai, Rissman, Robert A, Donohue, Michael C, Brewer, James B, Jenkins, Cecily, Harless, Kelly, Gessert, Devon, Aisen, Paul S

“…Insulin modulates aspects of brain function relevant to Alzheimer disease and can be delivered to the brain using intranasal devices. To date, the use of…”
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Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain by Coles, Jonathan A, Myburgh, Elmarie, Brewer, James M, McMenamin, Paul G

“…Rapid progress is being made in understanding the roles of the cerebral meninges in the maintenance of normal brain function, in immune surveillance, and as a…”
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A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy by Lee, Rebecca S., Waters, Andrew P., Brewer, James M.

“…Blood stage human malaria parasites may exploit erythropoietic tissue niches and colonise erythroid progenitors; however, the precise influence of the…”
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Nanoalum adjuvanted vaccines: small details make a big difference by Raponi, Arianna, Brewer, James M., Garside, Paul, Laera, Donatello

“…•Modelling Aluminium salt formulations to the desired type of vaccine immune response.•Reducing the size of Aluminium particles to obtain more effective…”
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Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors by Hu, Desheng, Mohanta, Sarajo K., Yin, Changjun, Peng, Li, Ma, Zhe, Srikakulapu, Prasad, Grassia, Gianluca, MacRitchie, Neil, Dever, Gary, Gordon, Peter, Burton, Francis L., Ialenti, Armando, Sabir, Suleman R., McInnes, Iain B., Brewer, James M., Garside, Paul, Weber, Christian, Lehmann, Thomas, Teupser, Daniel, Habenicht, Livia, Beer, Michael, Grabner, Rolf, Maffia, Pasquale, Weih, Falk, Habenicht, Andreas J.R.

“…Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in…”
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Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score by Desikan, Rahul S, Fan, Chun Chieh, Wang, Yunpeng, Schork, Andrew J, Cabral, Howard J, Cupples, L Adrienne, Thompson, Wesley K, Besser, Lilah, Kukull, Walter A, Holland, Dominic, Chen, Chi-Hua, Brewer, James B, Karow, David S, Kauppi, Karolina, Witoelar, Aree, Karch, Celeste M, Bonham, Luke W, Yokoyama, Jennifer S, Rosen, Howard J, Miller, Bruce L, Dillon, William P, Wilson, David M, Hess, Christopher P, Pericak-Vance, Margaret, Haines, Jonathan L, Farrer, Lindsay A, Mayeux, Richard, Hardy, John, Goate, Alison M, Hyman, Bradley T, Schellenberg, Gerard D, McEvoy, Linda K, Andreassen, Ole A, Dale, Anders M

“…Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in…”
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One-Year Brain Atrophy Evident in Healthy Aging by Fjell, Anders M, Walhovd, Kristine B, Fennema-Notestine, Christine, McEvoy, Linda K, Hagler, Donald J, Holland, Dominic, Brewer, James B, Dale, Anders M

“…An accurate description of changes in the brain in healthy aging is needed to understand the basis of age-related changes in cognitive function…”
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Sex differences in plasma p-tau181 associations with Alzheimer’s disease biomarkers, cognitive decline, and clinical progression by Tsiknia, Amaryllis A., Edland, Steven D., Sundermann, Erin E., Reas, Emilie T., Brewer, James B., Galasko, Douglas, Banks, Sarah J.

“…Studies have shown that women on the Alzheimer’s disease (AD) continuum have more pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some…”
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Brain cell type-specific enhancer-promoter interactome maps and disease - risk association by Nott, Alexi, Holtman, Inge R, Coufal, Nicole G, Schlachetzki, Johannes C M, Yu, Miao, Hu, Rong, Han, Claudia Z, Pena, Monique, Xiao, Jiayang, Wu, Yin, Keulen, Zahara, Pasillas, Martina P, O'Connor, Carolyn, Nickl, Christian K, Schafer, Simon T, Shen, Zeyang, Rissman, Robert A, Brewer, James B, Gosselin, David, Gonda, David D, Levy, Michael L, Rosenfeld, Michael G, McVicker, Graham, Gage, Fred H, Ren, Bing, Glass, Christopher K

“…Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic…”
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Dose-Dependent Cortical Thinning After Partial Brain Irradiation in High-Grade Glioma by Karunamuni, Roshan, PhD, Bartsch, Hauke, PhD, White, Nathan S., PhD, Moiseenko, Vitali, PhD, Carmona, Ruben, MD, MAS, Marshall, Deborah C., BA, Seibert, Tyler M., PhD, MD, McDonald, Carrie R., PhD, Farid, Nikdokht, MD, Krishnan, Anithapriya, PhD, Kuperman, Joshua, PhD, Mell, Loren, MD, Brewer, James B., PhD, MD, Dale, Anders M., PhD, Hattangadi-Gluth, Jona A., MD

“…Purpose Radiation-induced cognitive deficits may be mediated by tissue damage to cortical regions. Volumetric changes in cortex can be reliably measured using…”
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Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria by Shaw, Tovah N, Stewart-Hutchinson, Phillip J, Strangward, Patrick, Dandamudi, Durga B, Coles, Jonathan A, Villegas-Mendez, Ana, Gallego-Delgado, Julio, van Rooijen, Nico, Zindy, Egor, Rodriguez, Ana, Brewer, James M, Couper, Kevin N, Dustin, Michael L

“…There is significant evidence that brain-infiltrating CD8+ T cells play a central role in the development of experimental cerebral malaria (ECM) during…”
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Antigen depot is not required for alum adjuvanticity by Hutchison, Sharon, Benson, Robert A., Gibson, Vivienne B., Pollock, Abigail H., Garside, Paul, Brewer, James M.

“…Alum adjuvants have been in continuous clinical use for more than 80 yr. While the prevailing theory has been that depot formation and the associated slow…”
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Corrigendum to “Nanoalum adjuvanted vaccines: Small details make a big difference” [Semin. Immunol. 56 (2021) 101544] by Raponi, Arianna, Brewer, James M., Garside, Paul, Laera, Donatello

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Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis by Kunkle, Brian W, Schmidt, Michael, Klein, Hans-Ulrich, Naj, Adam C, Hamilton-Nelson, Kara L, Larson, Eric B, Evans, Denis A, De Jager, Phil L, Crane, Paul K, Buxbaum, Joe D, Ertekin-Taner, Nilufer, Barnes, Lisa L, Fallin, M Daniele, Manly, Jennifer J, Go, Rodney C P, Obisesan, Thomas O, Kamboh, M Ilyas, Bennett, David A, Hall, Kathleen S, Goate, Alison M, Foroud, Tatiana M, Martin, Eden R, Wang, Li-Sao, Byrd, Goldie S, Farrer, Lindsay A, Haines, Jonathan L, Schellenberg, Gerard D, Mayeux, Richard, Pericak-Vance, Margaret A, Reitz, Christiane, Graff-Radford, Neill R, Martinez, Izri, Ayodele, Temitope, Logue, Mark W, Cantwell, Laura B, Jean-Francois, Melissa, Kuzma, Amanda B, Adams, L D, Vance, Jeffery M, Cuccaro, Michael L, Chung, Jaeyoon, Mez, Jesse, Lunetta, Kathryn L, Jun, Gyungah R, Lopez, Oscar L, Hendrie, Hugh C, Reiman, Eric M, Kowall, Neil W, Leverenz, James B, Small, Scott A, Levey, Allan I, Golde, Todd E, Saykin, Andrew J, Starks, Takiyah D, Albert, Marilyn S, Hyman, Bradley T, Petersen, Ronald C, Sano, Mary, Wisniewski, Thomas, Vassar, Robert, Kaye, Jeffrey A, Henderson, Victor W, DeCarli, Charles, LaFerla, Frank M, Brewer, James B, Miller, Bruce L, Swerdlow, Russell H, Van Eldik, Linda J, Paulson, Henry L, Trojanowski, John Q, Chui, Helena C, Rosenberg, Roger N, Craft, Suzanne, Grabowski, Thomas J, Asthana, Sanjay, Morris, John C, Strittmatter, Stephen M, Kukull, Walter A

“…Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer…”
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A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease by Turner, R Scott, Thomas, Ronald G, Craft, Suzanne, van Dyck, Christopher H, Mintzer, Jacobo, Reynolds, Brigid A, Brewer, James B, Rissman, Robert A, Raman, Rema, Aisen, Paul S

“…OBJECTIVE:A randomized, placebo-controlled, double-blind, multicenter 52-week phase 2 trial of resveratrol in individuals with mild to moderate Alzheimer…”
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Introduction to the Special Issue: Nanoparticles and immune responses by Brewer, James M., Irvine, Darrell J.

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Cerebral cortex regions selectively vulnerable to radiation dose-dependent atrophy by Seibert, Tyler M., MD, PhD, Karunamuni, Roshan, PhD, Kaifi, Samar, MD, Burkeen, Jeffrey, MD, Connor, Michael, BS, Krishnan, AnithaPriya, PhD, White, Nathan S., PhD, Farid, Nikdokht, MD, Bartsch, Hauke, PhD, Murzin, Vyacheslav, PhD, Nguyen, Tanya T., PhD, Moiseenko, Vitali, PhD, Brewer, James B., MD, PhD, McDonald, Carrie R., PhD, Dale, Anders M., PhD, Hattangadi-Gluth, Jona A., MD

“…Abstract Purpose /Objectives: Neurologic deficits after brain radiotherapy (RT) typically involve decline in higher-order cognitive functions such as attention…”
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Reversal of the TCR Stop Signal by CTLA-4 by Schneider, Helga, Downey, Jos, Smith, Andrew, Zinselmeyer, Bernd H, Rush, Catherine, Brewer, James M, Wei, Bin, Hogg, Nancy, Garside, Paul, Rudd, Christopher E

“…The coreceptor cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is pivotal in regulating the threshold of signals during T cell activation, although the…”
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Radiation Dose–Dependent Hippocampal Atrophy Detected With Longitudinal Volumetric Magnetic Resonance Imaging by Seibert, Tyler M., Karunamuni, Roshan, Bartsch, Hauke, Kaifi, Samar, Krishnan, Anitha Priya, Dalia, Yoseph, Burkeen, Jeffrey, Murzin, Vyacheslav, Moiseenko, Vitali, Kuperman, Joshua, White, Nathan S., Brewer, James B., Farid, Nikdokht, McDonald, Carrie R., Hattangadi-Gluth, Jona A.

“…After radiation therapy (RT) to the brain, patients often experience memory impairment, which may be partially mediated by damage to the hippocampus…”
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