Search Results - "BREUER, Olof"

Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans[S] by Bonde, Ylva, Breuer, Olof, Lütjohann, Dieter, Sjöberg, Stefan, Angelin, Bo, Rudling, Mats

“…Reduced plasma LDL-cholesterol is a hallmark of hyperthyroidism and is caused by transcriptional stimulation of LDL receptors in the liver. Here, we…”
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Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites by Breuer, Olof, Brodin, Ola, Razaghi, Ali, Brodin, David, Gammelgaard, Bente, Björnstedt, Mikael

“…Cancer is one of the main causes of human death globally and novel chemotherapeutics are desperately required. As a simple selenium oxide, selenite is a very…”
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Use of an 18O2 Inhalation Technique and Mass Isotopomer Distribution Analysis to Study Oxygenation of Cholesterol in Rat by Breuer, Olof, Björkhem, Ingemar

“…Cholesterol oxidation products (oxysterols) have been detected in many different tissues, often at concentrations 103 to 104 times lower than cholesterol. This…”
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Human plasma protein levels alter the in vitro antifungal activity of caspofungin: An explanation to the effect in critically ill? by Kurland, Siri, Löwdin, Elisabeth, Furebring, Mia, Shams, Ayda, Chryssanthou, Erja, Lagerbäck, Pernilla, Tängden, Thomas, Breuer, Olof, Sjölin, Jan

“…Background Recent studies have shown low caspofungin concentrations in critically ill patients. In some patients, the therapeutic target, area under the total…”
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Simultaneous quantification of several cholesterol autoxidation and monohydroxylation products by isotope-dilution mass spectrometry by Breuer, O, Björkhem, I

“…An assay based on isotope-dilution mass spectrometry with deuterium-labeled internal standards was developed for simultaneous quantification of cholest-5-ene-3…”
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Abstract CT182: OXC-101 shows favorable safety profile in first in human phase 1 trial in patients with advanced solid cancer by Yachnin, Jeffrey, Ny, Lars, Sandvall, Teresa, Sanjiv, Kumar, Scobie, Martin, Platzack, Björn, Barancewski, Pawel, Breuer, Olof, Gorgoulis, Vassilis, Pateras, Ioannis S., Klockare, Maria, Smith, Austin, Berglund, Ulrika Warpman, Helleday, Thomas

“…Abstract Purpose: Many cancers suffer from dysfunctional redox status. MTH1 protects cancer cells from oxidative DNA damage by preventing incorporation of…”
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Improving lithium dose prediction using population pharmacokinetics and pharmacogenomics: a cohort genome-wide association study in Sweden by Millischer, Vincent, Matheson, Granville J, Bergen, Sarah E, Coombes, Brandon J, Ponzer, Katja, Wikström, Fredrik, Jagiello, Karolina, Lundberg, Martin, Stenvinkel, Peter, Biernacka, Joanna M, Breuer, Olof, Martinsson, Lina, Landén, Mikael, Backlund, Lena, Lavebratt, Catharina, Schalling, Martin

“…Lithium is the most effective treatment for bipolar disorder, resulting in strong suicide prevention effects. The therapeutic range of lithium, however, is…”
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Importance of a Novel Oxidative Mechanism for Elimination of Brain Cholesterol by Björkhem, Ingemar, Lütjohann, Dieter, Breuer, Olof, Sakinis, Augustinas, Wennmalm, Åke

“…The brain is the most cholesterol-rich organ in the body. Brain cholesterol is characterized by a very low turnover with very little exchange with lipoproteins…”
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VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation by Marinova, Milka, Lütjohann, Dieter, Breuer, Olof, Kölsch, Heike, Westhofen, Philipp, Watzka, Matthias, Mengel, Martin, Stoffel-Wagner, Birgit, Hartmann, Gunther, Coch, Christoph, Oldenburg, Johannes

“…Objective The pharmacokinetics of phylloquinone (vitamin K1) were evaluated in healthy human adult volunteers (15 male and 15 female) following oral and…”
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Cholesterol Homeostasis in Human Brain: Evidence for an Age-Dependent Flux of 24S-Hydroxycholesterol from the Brain into the Circulation by Lütjohann, Dieter, Breuer, Olof, Ahlborg, Gunvor, Nennesmo, Inger, Sidén, Åke, Diczfalusy, Ulf, Björkhem, Ingemar

“…We have investigated whether side chainhydroxylated cholesterol species are important for elimination of cholesterol from the brain. Plasma concentrations of…”
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Determination of Cholesterol Oxidation Products in Human Plasma by Isotope Dilution-Mass Spectrometry by Dzeletovic, S., Breuer, O., Lund, E., Diczfalusy, U.

“…A method based on isotope dilution-mass spectrometry was developed for the determination of nine cholesterol oxidation products in human plasma. The…”
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Pharmacokinetics of ropivacaine in patients with chronic end-stage liver disease by JOKINEN, Mika J, NEUVONEN, Pertti J, LINDGREN, Leena, HÖCKERSTEDT, Krister, SJÖVALL, Jan, BREUER, Olof, ASKEMARK, Yvonne, AHONEN, Jouni, OLKKOLA, Klaus T

“…Ropivacaine is mainly eliminated by hepatic metabolism. The authors studied the effect of chronic end-stage liver disease on the pharmacokinetics of…”
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Use of an O Inhalation Technique and Mass Isotopomer Distribution Analysis to Study Oxygenation of Cholesterol in Rat by Olof Breuer, Ingemar Björkhem

“…Cholesterol oxidation products (oxysterols) have been detected in many different tissues, often at concentrations 10 3 to 10 4 times lower than cholesterol…”
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Evidence that 24- and 27-hydroxylation are not involved in the cholesterol-induced down-regulation of hydroxymethylglutaryl-CoA reductase in mouse liver by Lund, E, Breuer, O, Björkhem, I

“…Several authors have suggested that 27-hydroxycholesterol may be an important physiological regulator of cholesterol homeostasis. In the present study we…”
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Transformation of subcutaneous nitric oxide into nitrate in the rat by Benthin, G, Björkhem, I, Breuer, O, Sakinis, A, Wennmalm, A

“…Following its addition to arterialized blood in vitro, nitric oxide (NO) is transformed into nitrate in the erythrocytes. Inhaled NO is similarly transformed…”
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Enzymatic conversion of leukotriene B4 to 6-trans-leukotriene B4 by rat kidney homogenates by Breuer, O, Hammarström, S

“…A novel isomerase reaction leading to conversion of leukotriene B4 to its 6-trans isomer was detected in rat kidney homogenates. The structure of the…”
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Cholesterol 7α‐hydroxylase is up‐regulated by the competitive inhibitor 7‐oxocholesterol in rat liver by BREUER, Olof, SUDJANA‐SUGIAMAN, Elly, EGGERTSEN, Gösta, CHIANG, John Y. L., BJÖRKHEM, Ingemar

“…Rats of the Sprague‐Dawley strain were infused intravenously with a fat emulsion (Intralipid, trademark of Kabi Pharmacia, Uppsala, Sweden) containing…”
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The oxysterols cholest-5-ene-3β,4α-diol, cholest-5-ene-3β,4β-diol and cholestane-3β,5α,6α-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaques by Breuer, Olof, Dzeletovic, Susanna, Lund, Erik, Diczfalusy, Ulf

“…Isolated human low density lipoprotein (LDL) was oxidized with either cupric ions or soybean lipoxygenase and linoleic acid. Cholesterol oxidation products…”
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