Search Results - "BRESOLIN, Nereo"

Extracellular vesicles and amyotrophic lateral sclerosis: from misfolded protein vehicles to promising clinical biomarkers by Gagliardi, Delia, Bresolin, Nereo, Comi, Giacomo Pietro, Corti, Stefania

“…Extracellular vesicles (EVs) are small reservoirs of different molecules and important mediators of cell-to-cell communication. As putative vehicles of…”
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The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease by Monzio Compagnoni, Giacomo, Di Fonzo, Alessio, Corti, Stefania, Comi, Giacomo P., Bresolin, Nereo, Masliah, Eliezer

“…Although the pathogenesis of neurodegenerative diseases is still widely unclear, various mechanisms have been proposed and several pieces of evidence are…”
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Neural Stem Cell Transplantation for Neurodegenerative Diseases by De Gioia, Roberta, Biella, Fabio, Citterio, Gaia, Rizzo, Federica, Abati, Elena, Nizzardo, Monica, Bresolin, Nereo, Comi, Giacomo Pietro, Corti, Stefania

“…Neurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. Neural stem cell (NSC) transplantation has…”
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Brain Mitochondria, Aging, and Parkinson's Disease by Rango, Mario, Bresolin, Nereo

“…This paper reconsiders the role of mitochondria in aging and in Parkinson's Disease (PD). The most important risk factor for PD is aging. Alterations in…”
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Noncoding RNAs in Duchenne and Becker muscular dystrophies: role in pathogenesis and future prognostic and therapeutic perspectives by Brusa, Roberta, Magri, Francesca, Bresolin, Nereo, Comi, Giacomo Pietro, Corti, Stefania

“…Noncoding RNAs (ncRNAs), such as miRNAs and long noncoding RNAs, are key regulators of gene expression at the post-transcriptional level and represent…”
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Management of patients with neuromuscular disorders at the time of the SARS-CoV-2 pandemic by Costamagna, Gianluca, Abati, Elena, Bresolin, Nereo, Comi, Giacomo Pietro, Corti, Stefania

“…The novel Coronavirus disease-19 (COVID-19) pandemic has posed several challenges for neuromuscular disorder (NMD) patients. The risk of a severe course of…”
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Glial cells involvement in spinal muscular atrophy: Could SMA be a neuroinflammatory disease? by Abati, Elena, Citterio, Gaia, Bresolin, Nereo, Comi, Giacomo P., Corti, Stefania

“…Spinal muscular atrophy (SMA) is a severe, inherited disease characterized by the progressive degeneration and death of motor neurons of the anterior horns of…”
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Preconditioning and Cellular Engineering to Increase the Survival of Transplanted Neural Stem Cells for Motor Neuron Disease Therapy by Abati, Elena, Bresolin, Nereo, Comi, Giacomo Pietro, Corti, Stefania

“…Despite the extensive research effort that has been made in the field, motor neuron diseases, namely, amyotrophic lateral sclerosis and spinal muscular…”
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Diagnostic and Prognostic Role of Blood and Cerebrospinal Fluid and Blood Neurofilaments in Amyotrophic Lateral Sclerosis: A Review of the Literature by Gagliardi, Delia, Meneri, Megi, Saccomanno, Domenica, Bresolin, Nereo, Comi, Giacomo Pietro, Corti, Stefania

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting upper and lower motor neurons (MNs) that still lacks an efficacious…”
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Clinical and genetic features of a cohort of patients with MFN2-related neuropathy by Abati, Elena, Manini, Arianna, Velardo, Daniele, Del Bo, Roberto, Napoli, Laura, Rizzo, Federica, Moggio, Maurizio, Bresolin, Nereo, Bellone, Emilia, Bassi, Maria Teresa, D’Angelo, Maria Grazia, Comi, Giacomo Pietro, Corti, Stefania

“…Charcot–Marie–Tooth disease type 2A (CMT2A) is a rare inherited axonal neuropathy caused by mutations in MFN2 gene, which encodes Mitofusin 2, a transmembrane…”
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Molecular Therapeutic Strategies for Spinal Muscular Atrophies: Current and Future Clinical Trials by Zanetta, Chiara, MD, Nizzardo, Monica, PhD, Simone, Chiara, PhD, Monguzzi, Erika, PhD, Bresolin, Nereo, MD, Comi, Giacomo P., MD, Corti, Stefania, MD, PhD

“…Abstract Background Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease caused by mutations in the survival motor neuron gene ( SMN1 )…”
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Molecular Approaches for the Treatment of Pompe Disease by Bellotti, Anita Sofia, Andreoli, Luca, Ronchi, Dario, Bresolin, Nereo, Comi, Giacomo P., Corti, Stefania

“…Glycogen storage disease type II (GSDII, Pompe disease) is a rare metabolic disorder caused by a deficiency of acid alpha-glucosidase (GAA), an enzyme…”
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MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives by Stuppia, Giulia, Rizzo, Federica, Riboldi, Giulietta, Del Bo, Roberto, Nizzardo, Monica, Simone, Chiara, Comi, Giacomo P, Bresolin, Nereo, Corti, Stefania

“…Abstract Mitofusin 2 (MFN2) is a GTPase dynamin-like protein of the outer mitochondrial membrane, encoded in the nuclear genome by the MFN2 gene located on the…”
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MicroRNAs as regulators of cell death mechanisms in amyotrophic lateral sclerosis by Gagliardi, Delia, Comi, Giacomo P., Bresolin, Nereo, Corti, Stefania

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting upper and lower motor neurons (MNs), resulting in paralysis and…”
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Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions by Fumagalli, Matteo, Pozzoli, Uberto, Cagliani, Rachele, Comi, Giacomo P, Riva, Stefania, Clerici, Mario, Bresolin, Nereo, Sironi, Manuela

“…Many human genes have adapted to the constant threat of exposure to infectious agents; according to the "hygiene hypothesis," lack of exposure to parasites in…”
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Mental health and coping strategies in families of children and young adults with muscular dystrophies by Tesei, Alessandra, Nobile, Maria, Colombo, Paola, Civati, Federica, Gandossini, Sandra, Mani, Elisa, Molteni, Massimo, Bresolin, Nereo, D’Angelo, Grazia

“…Background Living with a progressive disease as muscular dystrophy (MD) can be challenging for the patient and the entire family from both emotional and…”
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MicroRNA expression analysis identifies a subset of downregulated miRNAs in ALS motor neuron progenitors by Rizzuti, Mafalda, Filosa, Giuseppe, Melzi, Valentina, Calandriello, Luca, Dioni, Laura, Bollati, Valentina, Bresolin, Nereo, Comi, Giacomo Pietro, Barabino, Silvia, Nizzardo, Monica, Corti, Stefania

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder that is characterized by a progressive degeneration of motor neurons (MNs). The…”
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Nusinersen treatment and cerebrospinal fluid neurofilaments: An explorative study on Spinal Muscular Atrophy type 3 patients by Faravelli, Irene, Meneri, Megi, Saccomanno, Domenica, Velardo, Daniele, Abati, Elena, Gagliardi, Delia, Parente, Valeria, Petrozzi, Lucia, Ronchi, Dario, Stocchetti, Nino, Calderini, Edoardo, D’Angelo, Grazia, Chidini, Giovanna, Prandi, Edi, Ricci, Giulia, Siciliano, Gabriele, Bresolin, Nereo, Comi, Giacomo Pietro, Corti, Stefania, Magri, Francesca, Govoni, Alessandra

“…The antisense oligonucleotide Nusinersen has been recently licensed to treat spinal muscular atrophy (SMA). Since SMA type 3 is characterized by variable…”
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Current understanding of and emerging treatment options for spinal muscular atrophy with respiratory distress type 1 (SMARD1) by Perego, Martina G. L., Galli, Noemi, Nizzardo, Monica, Govoni, Alessandra, Taiana, Michela, Bresolin, Nereo, Comi, Giacomo P., Corti, Stefania

“…Spinal muscular atrophy (SMA) with respiratory distress type 1 (SMARD1) is an autosomal recessive motor neuron disease that is characterized by distal and…”
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Human induced pluripotent stem cell models for the study and treatment of Duchenne and Becker muscular dystrophies by Piga, Daniela, Salani, Sabrina, Magri, Francesca, Brusa, Roberta, Mauri, Eleonora, Comi, Giacomo P., Bresolin, Nereo, Corti, Stefania

“…Duchenne and Becker muscular dystrophies are the most common muscle diseases and are both currently incurable. They are caused by mutations in the dystrophin…”
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