Search Results - "BRENTNALL, T. A"
-
1
Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis
Published in Annals of internal medicine (16-01-2001)“…Patients with ulcerative colitis and primary sclerosing cholangitis are at high risk for colonic dysplasia and cancer. This risk approaches 50% after 25 years…”
Get full text
Journal Article -
2
Early diagnosis and treatment of pancreatic dysplasia in patients with a family history of pancreatic cancer
Published in Annals of internal medicine (17-08-1999)“…Pancreatic cancer, the fourth most common cause of cancer death in the United States, is hereditary in an estimated 10% of cases. Surveillance of patients with…”
Get full text
Journal Article -
3
Risk and natural history of colonic neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis
Published in Gastroenterology (New York, N.Y. 1943) (01-02-1996)“…BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) has been suggested as a risk factor for the development of colorectal cancer in ulcerative colitis…”
Get full text
Journal Article -
4
Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis
Published in Cancer research (Chicago, Ill.) (15-10-1999)“…Patients with long-standing ulcerative colitis (UC) are at increased risk for colon cancer. These cancers are thought to arise from preexisting dysplasia in a…”
Get full text
Journal Article -
5
Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis
Published in Gastroenterology (New York, N.Y. 1943) (01-08-1994)“…In long-term extensive ulcerative colitis, aneuploidy occurs earlier and loss of heterozygosity for p53 (p53 LOH) later during histological progression towards…”
Get more information
Journal Article -
6
Inherited predisposition to pancreatic cancer
Published in Gut (01-02-2001)“…Traditional chemotherapy and radiotherapy regimens have been rather ineffective in providing control of the disease. 1 The only consistent risk factor…”
Get full text
Journal Article -
7
Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis
Published in Cancer research (Chicago, Ill.) (15-03-1996)“…Microsatellite instability (MIN) has been detected in many cancer types; however, recently we also observed it in the nonneoplastic but inflammatory setting of…”
Get full text
Journal Article -
8
Cancer surveillance of patients from familial pancreatic cancer kindreds
Published in The Medical clinics of North America (01-05-2000)“…The family history can be used to determine which family members warrant surveillance and when to start it. Surveillance should be started at least 1 decade…”
Get more information
Journal Article -
9
DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis
Published in Gastroenterology (New York, N.Y. 1943) (01-11-1992)“…The objective of the present study was to determine whether abnormal epithelial DNA content (aneuploidy) in colonic biopsy specimens from ulcerative colitis…”
Get more information
Journal Article -
10
Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis
Published in Cancer research (Chicago, Ill.) (01-10-1995)“…ras oncogene mutations and microsatellite instability (MIN) have been described in pancreatic cancer studies from paraffin blocks and fresh frozen tissue. We…”
Get full text
Journal Article -
11
Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele
Published in Gastroenterology (New York, N.Y. 1943) (01-11-1992)“…Neoplastic progression in patients with chronic ulcerative colitis (UC) is characterized by the development of epithelial dysplasia, which is accompanied by…”
Get more information
Journal Article -
12
Microsatellite instability. Shifting concepts in tumorigenesis
Published in The American journal of pathology (01-09-1995)Get full text
Journal Article -
13
Accelerated age-related CpG island methylation in ulcerative colitis
Published in Cancer research (Baltimore) (01-05-2001)“…CpG island hypermethylation is a mechanism of gene silencing that can be usurped by neoplastic cells to inactivate undesirable genes. In the colon,…”
Get full text
Conference Proceeding Journal Article -
14
Persistent nausea and anorexia after marrow transplantation : A prospective study of 78 patients
Published in Transplantation (27-11-1998)“…Persistent nausea, vomiting, anorexia, and poor oral intake are common after hematopoietic cell transplantation. In the past, herpesvirus infections and acute…”
Get full text
Journal Article -
15
A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis
Published in Gastroenterology (New York, N.Y. 1943) (01-07-1995)“…The DNA mismatch repair gene human MSH2 shows a germline mutation in certain family members with hereditary nonpolyposis colorectal cancer. There is an…”
Get more information
Journal Article -
16
Chromosomal instability in ulcerative colitis is related to telomere shortening
Published in Nature genetics (01-10-2002)“…Ulcerative colitis, a chronic inflammatory disease of the colon, is associated with a high risk of colorectal carcinoma that is thought to develop through…”
Get full text
Journal Article -
17
Familial pancreatic adenocarcinoma: association with diabetes and early molecular diagnosis
Published in Journal of medical genetics (01-05-1995)“…We report a large pedigree in which pancreatic cancer is inherited in an autosomal dominant fashion. Diabetes and exocrine insufficiency was observed in all…”
Get full text
Journal Article -
18
The Role of Cyclooxygenase 2 in Ulcerative Colitis-Associated Neoplasia
Published in The American journal of pathology (01-09-2000)“…Cyclooxygenase 2 (COX-2) overexpression has been described in sporadic colonic neoplasia, but its role in ulcerative colitis (UC) neoplastic progression…”
Get full text
Journal Article -
19
Characterization of the neoplastic phenotype in the familial atypical multiple‐mole melanoma–pancreatic carcinoma syndrome
Published in Cancer (15-08-2003)“…BACKGROUND Previous studies suggest that the familial atypical multiple‐mole melanoma (FAMMM) syndrome may predispose affected families to nonmelanoma…”
Get full text
Journal Article -
20
Inherited Pancreatic Cancer: Surveillance and Treatment Strategies for Affected Families
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (01-01-2001)“…Background:Nearly 10% of pancreatic cancers are hereditary in origin, and in some individuals, the risk of pancreatic cancer approaches 50%. A number of…”
Get full text
Journal Article