Search Results - "BRENNAN, John"

Biosensing with DNAzymes by McConnell, Erin M, Cozma, Ioana, Mou, Quanbing, Brennan, John D, Lu, Yi, Li, Yingfu

“…This article provides a comprehensive review of biosensing with DNAzymes, providing an overview of different sensing applications while highlighting major…”
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A Multi‐component All‐DNA Biosensing System Controlled by a DNAzyme by Zhou, Zhixue, Brennan, John D., Li, Yingfu

“…We report on a programmable all‐DNA biosensing system that centers on the use of a 4‐way junction (4WJ) to transduce a DNAzyme reaction into an amplified…”
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A DNAzyme Feedback Amplification Strategy for Biosensing by Liu, Meng, Zhang, Qiang, Chang, Dingran, Gu, Jimmy, Brennan, John D., Li, Yingfu

“…We report a signal amplification strategy termed DNAzyme feedback amplification (DFA) that takes advantage of rolling‐circle amplification (RCA) and an…”
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DNAzymes as key components of biosensing systems for the detection of biological targets by Cozma, Ioana, McConnell, Erin M., Brennan, John D., Li, Yingfu

“…DNAzymes are synthetic functional nucleic acids that have found widespread use in biosensing applications both for molecular recognition and signal generation…”
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Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library by Li, Jiuxing, Zhang, Zijie, Gu, Jimmy, Stacey, Hannah D, Ang, Jann C, Capretta, Alfredo, Filipe, Carlos D M, Mossman, Karen L, Balion, Cynthia, Salena, Bruno J, Yamamura, Deborah, Soleymani, Leyla, Miller, Matthew S, Brennan, John D, Li, Yingfu

“…Abstract We performed in vitro selection experiments to identify DNA aptamers for the S1 subunit of the SARS-CoV-2 spike protein (S1 protein). Using a pool of…”
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Making target sites in large structured RNAs accessible to RNA-cleaving DNAzymes through hybridization with synthetic DNA oligonucleotides by Nurmi, Connor, Gu, Jimmy, Mathai, Amal, Brennan, John D, Li, Yingfu

“…Abstract The 10–23 DNAzyme is one of the most active DNA-based enzymes, and in theory, can be designed to target any purine-pyrimidine junction within an RNA…”
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A Paper Sensor Printed with Multifunctional Bio/Nano Materials by Hui, Christy Y., Liu, Meng, Li, Yingfu, Brennan, John D.

“…We report a paper‐based aptasensor platform that uses two reaction zones and a connecting bridge along with printed multifunctional bio/nano materials to…”
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A Rapid Sputum-based Lateral Flow Assay for Airway Eosinophilia using an RNA-cleaving DNAzyme Selected for Eosinophil Peroxidase by Ali, M Monsur, Mukherjee, Manali, Radford, Katherine, Patel, Zil, Capretta, Alfredo, Nair, Parameswaran, Brennan, John David

“…The first protein-binding allosteric RNA-cleaving DNAzyme (RCD) obtained by direct in vitro selection against eosinophil peroxidase (EPX), a validated marker…”
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A DNAzyme‐Based Colorimetric Paper Sensor for Helicobacter pylori by Ali, M. Monsur, Wolfe, Michael, Tram, Kha, Gu, Jimmy, Filipe, Carlos D. M., Li, Yingfu, Brennan, John D.

“…The reliable detection of pathogenic bacteria in complex biological samples using simple assays or devices remains a major challenge. Herein, we report a…”
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In Vitro Selection of Circular DNA Aptamers for Biosensing Applications by Liu, Meng, Yin, Qingxin, Chang, Yangyang, Zhang, Qiang, Brennan, John D., Li, Yingfu

“…We report on the first effort to select DNA aptamers from a circular DNA library, which resulted in the discovery of two high‐affinity circular DNA aptamers…”
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High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva by Zhang, Zijie, Pandey, Richa, Li, Jiuxing, Gu, Jimmy, White, Dawn, Stacey, Hannah D., Ang, Jann C., Steinberg, Catherine‐Jean, Capretta, Alfredo, Filipe, Carlos D. M., Mossman, Karen, Balion, Cynthia, Miller, Matthew S., Salena, Bruno J., Yamamura, Deborah, Soleymani, Leyla, Brennan, John D., Li, Yingfu

“…We report a simple and rapid saliva‐based SARS‐CoV‐2 antigen test that utilizes a newly developed dimeric DNA aptamer, denoted as DSA1N5, that specifically…”
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Nucleic Acid Enzyme-Activated CRISPR-Cas12a With Circular CRISPR RNA for Biosensing by Wu, Yunping, Chang, Dingran, Chang, Yangyang, Zhang, Qiang, Liu, Yi, Brennan, John D, Li, Yingfu, Liu, Meng

“…clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems are increasingly used in biosensor development. However, directly translating…”
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A Lateral Flow Test for Staphylococcus aureus in Nasal Mucus Using a New DNAzyme as the Recognition Element by Ali, M. Monsur, Silva, Ryan, White, Dawn, Mohammadi, Saeed, Li, Yingfu, Capretta, Alfredo, Brennan, John D.

“…Detection of pathogenic bacteria in complex biological matrices remains a major challenge. Herein, we report the selection and optimization of a new DNAzyme…”
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A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research by MacDonald, Elayne, Dadds, Mark R, Brennan, John L, Williams, Katrina, Levy, Florence, Cauchi, Avril J

“…Summary Background Human research investigating the impact of intranasal oxytocin on psychological processes has accelerated over the last two decades. No…”
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Functional Nucleic Acids for Pathogenic Bacteria Detection by Chang, Dingran, Zakaria, Sandy, Esmaeili Samani, Sahar, Chang, Yangyang, Filipe, Carlos D. M, Soleymani, Leyla, Brennan, John D, Liu, Meng, Li, Yingfu

“…Conspectus Pathogens have long presented a significant threat to human lives, and hence the rapid detection of infectious pathogens is vital for improving…”
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A Graphene-Based Biosensing Platform Based on the Release of DNA Probes and Rolling Circle Amplification by Liu, Meng, Song, Jinping, Shuang, Shaomin, Dong, Chuan, Brennan, John D, Li, Yingfu

“…We report a versatile biosensing platform capable of achieving ultrasensitive detection of both small-molecule and macromolecular targets. The system features…”
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In‐vitro Clinical Diagnostics using RNA‐Cleaving DNAzymes by Ali, Monsur, Nair, Parameswaran, Capretta, Alfredo, Brennan, John D.

“…Over the last three decades, significant advancements have been made in the development of biosensors and bioassays that use RNA‐cleaving DNAzymes (RCDs) as…”
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A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern by Zhang, Zijie, Li, Jiuxing, Gu, Jimmy, Amini, Ryan, Stacey, Hannah D., Ang, Jann C., White, Dawn, Filipe, Carlos D. M., Mossman, Karen, Miller, Matthew S., Salena, Bruno J., Yamamura, Deborah, Sen, Payel, Soleymani, Leyla, Brennan, John D., Li, Yingfu

“…We report on a unique DNA aptamer, denoted MSA52, that displays universally high affinity for the spike proteins of wildtype SARS‐CoV‐2 as well as the Alpha,…”
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In Vitro Selection of a DNA Aptamer Targeting Degraded Protein Fragments for Biosensing by Liu, Meng, Wang, Jiayi, Chang, Yangyang, Zhang, Qiang, Chang, Dingran, Hui, Christy Y., Brennan, John D., Li, Yingfu

“…Protein biomarkers often exist as degradation fragments in biological samples, and affinity agents derived using a purified protein may not recognize them,…”
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Self‐Assembled Functional DNA Superstructures as High‐Density and Versatile Recognition Elements for Printed Paper Sensors by Liu, Meng, Zhang, Qiang, Kannan, Balamurali, Botton, Gianluigi A., Yang, Jie, Soleymani, Leyla, Brennan, John D., Li, Yingfu

“…Micrometer‐sized functional nucleic acid (FNA) superstructures (denoted as 3D DNA) were examined as a unique class of biorecognition elements to produce highly…”
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