Search Results - "BRENNAN, CHRISTOPHER M."

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  1. 1

    p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets by Brennan, Christopher M, Emerson, Jr, Charles P, Owens, Jane, Christoforou, Nicolas

    Published in JCI insight (22-06-2021)
    “…p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38…”
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    Journal Article
  2. 2

    DUX4 expression activates JNK and p38 MAP kinases in myoblasts by Brennan, Christopher M., Hill, Abby S., St. Andre, Michael, Li, Xianfeng, Madeti, Vijaya, Breitkopf, Susanne, Garren, Seth, Xue, Liang, Gilbert, Tamara, Hadjipanayis, Angela, Monetti, Mara, Emerson, Charles P., Moccia, Robert, Owens, Jane, Christoforou, Nicolas

    Published in Disease models & mechanisms (01-11-2022)
    “…Facioscapulohumeral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results in transcriptional…”
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    Journal Article
  3. 3

    Reduced heme levels underlie the exponential growth defect of the Shewanella oneidensis hfq mutant by Brennan, Christopher M, Mazzucca, Nicholas Q, Mezoian, Taylor, Hunt, Taylor M, Keane, Meaghan L, Leonard, Jessica N, Scola, Shelby E, Beer, Emma N, Perdue, Sarah, Pellock, Brett J

    Published in PloS one (30-10-2014)
    “…The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing…”
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    Journal Article
  4. 4

    HuR Binding to Cytoplasmic mRNA Is Perturbed by Heat Shock by Gallouzi, Imed-Eddine, Brennan, Christopher M., Stenberg, Myrna G., Swanson, Maurice S., Eversole, Ashley, Maizels, Nancy, Steitz, Joan A.

    “…AU-rich elements (AREs) located in the 3′untranslated region target the mRNAs encoding many protooncoproteins, cytokines, and lymphokines for rapid…”
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  5. 5

    Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells by Brennan, Christopher M, Vaites, Laura Pontano, Wells, Jonathan N, Santaguida, Stefano, Paulo, Joao A, Storchova, Zuzana, Harper, J Wade, Marsh, Joseph A, Amon, Angelika

    Published in Genes & development (01-08-2019)
    “…Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein…”
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  6. 6

    Aneuploidy Causes Non-genetic Individuality by Beach, Rebecca R., Ricci-Tam, Chiara, Brennan, Christopher M., Moomau, Christine A., Hsu, Pei-hsin, Hua, Bo, Silberman, Rebecca E., Springer, Michael, Amon, Angelika

    Published in Cell (06-04-2017)
    “…Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and cancer. Allelic variances have been thought…”
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  7. 7

    Shewanella oneidensis Hfq promotes exponential phase growth, stationary phase culture density, and cell survival by Brennan, Christopher M, Keane, Meghan L, Hunt, Taylor M, Goulet, Matthew T, Mazzucca, Nicholas Q, Sexton, Zachary, Mezoian, Taylor, Douglas, Katherine E, Osborn, Jessica M, Pellock, Brett J

    Published in BMC microbiology (08-02-2013)
    “…Hfq is an RNA chaperone protein that has been broadly implicated in sRNA function in bacteria. Here we describe the construction and characterization of a null…”
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    Journal Article
  8. 8

    Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response by Kane, Andrew J, Brennan, Christopher M, Xu, Acer E, Solís, Eric J, Terhorst, Allegra, Denic, Vladimir, Amon, Angelika

    Published in Molecular biology of the cell (15-08-2021)
    “…Aneuploid yeast cells are in a chronic state of proteotoxicity, yet do not constitutively induce the cytosolic unfolded protein response, or heat shock…”
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  9. 9

    Protein Ligands to HuR Modulate Its Interaction with Target mRNAs in Vivo by Brennan, Christopher M., Gallouzi, Imed-Eddine, Steitz, Joan A.

    Published in The Journal of cell biology (02-10-2000)
    “…AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene, cytokine, and lymphokine messages target them for rapid degradation. HuR,…”
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    Journal Article
  10. 10

    Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation by Brennan, Christopher M., Atkins, Kristen A., Druzgal, Colleen H., Gaskin, Cree M.

    Published in Skeletal radiology (01-03-2012)
    “…Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low…”
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    Journal Article
  11. 11

    Sonographic imaging of the posterior fossa utilizing the foramen magnum by Brennan, Christopher M., Taylor, George A.

    Published in Pediatric radiology (01-08-2010)
    “…In this essay, we describe our experience with a sonographic technique utilizing the foramen magnum to more clearly define anatomy in the neonatal posterior…”
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    Journal Article
  12. 12

    Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock by GALLOUZI, IMED-EDDINE, BRENNAN, CHRISTOPHER M., STEITZ, JOAN A.

    Published in RNA (Cambridge) (01-09-2001)
    “…AU-rich elements (AREs) located in the 3′ UTRs of the messenger RNAs (mRNAs) of many mammalian early response genes promote rapid mRNA turnover. HuR, an…”
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    Journal Article
  13. 13
  14. 14

    Reduced Heme Levels Underlie the Exponential Growth Defect of the Shewanella oneidensis hfq Mutant: e109879 by Brennan, Christopher M, Mazzucca, Nicholas Q, Mezoian, Taylor, Hunt, Taylor M, Keane, Meaghan L, Leonard, Jessica N, Scola, Shelby E, Beer, Emma N, Perdue, Sarah, Pellock, Brett J

    Published in PloS one (01-10-2014)
    “…The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing…”
    Get full text
    Journal Article
  15. 15
  16. 16

    Imaging Evaluation of the Rotator Cuff by Anderson, Mark W., MD, Brennan, Christopher, MD, Mittal, Amit, MD

    Published in Clinics in sports medicine (01-10-2012)
    “…The rotator cuff is a complex network of interwoven tendons that plays a key role in glenohumeral movement and stability. Cuff abnormality is a common source…”
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    Journal Article