Search Results - "BRENNAN, CHRISTOPHER M."
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p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets
Published in JCI insight (22-06-2021)“…p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38…”
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DUX4 expression activates JNK and p38 MAP kinases in myoblasts
Published in Disease models & mechanisms (01-11-2022)“…Facioscapulohumeral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results in transcriptional…”
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Reduced heme levels underlie the exponential growth defect of the Shewanella oneidensis hfq mutant
Published in PloS one (30-10-2014)“…The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing…”
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HuR Binding to Cytoplasmic mRNA Is Perturbed by Heat Shock
Published in Proceedings of the National Academy of Sciences - PNAS (28-03-2000)“…AU-rich elements (AREs) located in the 3′untranslated region target the mRNAs encoding many protooncoproteins, cytokines, and lymphokines for rapid…”
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Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells
Published in Genes & development (01-08-2019)“…Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein…”
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Aneuploidy Causes Non-genetic Individuality
Published in Cell (06-04-2017)“…Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down syndrome and cancer. Allelic variances have been thought…”
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Shewanella oneidensis Hfq promotes exponential phase growth, stationary phase culture density, and cell survival
Published in BMC microbiology (08-02-2013)“…Hfq is an RNA chaperone protein that has been broadly implicated in sRNA function in bacteria. Here we describe the construction and characterization of a null…”
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Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response
Published in Molecular biology of the cell (15-08-2021)“…Aneuploid yeast cells are in a chronic state of proteotoxicity, yet do not constitutively induce the cytosolic unfolded protein response, or heat shock…”
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Protein Ligands to HuR Modulate Its Interaction with Target mRNAs in Vivo
Published in The Journal of cell biology (02-10-2000)“…AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene, cytokine, and lymphokine messages target them for rapid degradation. HuR,…”
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Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation
Published in Skeletal radiology (01-03-2012)“…Scurvy is a lethal but treatable disease that is rare in industrialized countries. Caused by vitamin C deficiency, it is most prevalent in persons of low…”
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Sonographic imaging of the posterior fossa utilizing the foramen magnum
Published in Pediatric radiology (01-08-2010)“…In this essay, we describe our experience with a sonographic technique utilizing the foramen magnum to more clearly define anatomy in the neonatal posterior…”
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Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock
Published in RNA (Cambridge) (01-09-2001)“…AU-rich elements (AREs) located in the 3′ UTRs of the messenger RNAs (mRNAs) of many mammalian early response genes promote rapid mRNA turnover. HuR, an…”
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Shewanella oneidensisHfq promotes exponential phase growth, stationary phase culture density, and cell survival
Published in BMC microbiology (08-02-2013)Get full text
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Reduced Heme Levels Underlie the Exponential Growth Defect of the Shewanella oneidensis hfq Mutant: e109879
Published in PloS one (01-10-2014)“…The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing…”
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Imaging Evaluation of the Rotator Cuff
Published in Clinics in sports medicine (01-10-2012)“…The rotator cuff is a complex network of interwoven tendons that plays a key role in glenohumeral movement and stability. Cuff abnormality is a common source…”
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