Search Results - "BRENNAN, Alana T"
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Estimating retention in HIV care accounting for patient transfers: A national laboratory cohort study in South Africa
Published in PLoS medicine (11-06-2018)“…Systematic reviews have described high rates of attrition in patients with HIV receiving antiretroviral therapy (ART). However, migration and clinical transfer…”
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Prevalence and unmet need for diabetes care across the care continuum in a national sample of South African adults: Evidence from the SANHANES-1, 2011-2012
Published in PloS one (02-10-2017)“…South Africa faces an epidemic of chronic non-communicable diseases (NCDs), yet national surveillance is limited due to the lack of recent data. We used data…”
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A clinical algorithm for same-day HIV treatment initiation in settings with high TB symptom prevalence in South Africa: The SLATE II individually randomized clinical trial
Published in PLoS medicine (01-08-2020)“…Introduction In its 2017 revision of the global guidelines for HIV care and treatment, the World Health Organization (WHO) called for rapid or same-day…”
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Prevalence, incidence, predictors, treatment, and control of hypertension among HIV-positive adults on antiretroviral treatment in public sector treatment programs in South Africa
Published in PloS one (03-10-2018)“…One of the key risk factors for cardiovascular disease is hypertension. Hypertension, which leads to heart attacks and strokes, already affects one billion…”
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Causal language and strength of inference in academic and media articles shared in social media (CLAIMS): A systematic review
Published in PloS one (30-05-2018)“…The pathway from evidence generation to consumption contains many steps which can lead to overstatement or misinformation. The proliferation of internet-based…”
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Changing the South African national antiretroviral therapy guidelines: The role of cost modelling
Published in PloS one (30-10-2017)“…We were tasked by the South African Department of Health to assess the cost implications to the largest ART programme in the world of adopting sets of ART…”
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Simplified clinical algorithm for identifying patients eligible for same-day HIV treatment initiation (SLATE): Results from an individually randomized trial in South Africa and Kenya
Published in PLoS medicine (16-09-2019)“…The World Health Organization recommends "same-day" initiation of antiretroviral therapy (ART) for HIV patients who are eligible and ready. Identifying…”
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Integration of point-of-care screening for type 2 diabetes mellitus and hypertension with COVID-19 rapid antigen screening in Johannesburg, South Africa
Published in PloS one (07-07-2023)“…We sought to evaluate the yield and linkage-to-care for diabetes and hypertension screening alongside a study assessing the use of rapid antigen tests for…”
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The cost of adding rapid screening for diabetes, hypertension, and COVID-19 to COVID-19 vaccination queues in Johannesburg, South Africa
Published in BMC public health (16-07-2024)“…Non-communicable diseases (NCDs) are responsible for 51% of total mortality in South Africa, with a rising burden of hypertension (HTN) and diabetes mellitus…”
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Integration of point-of-care screening for type 2 diabetes mellitus and hypertension into the COVID-19 vaccine programme in Johannesburg, South Africa
Published in BMC public health (20-11-2023)“…South Africa grapples with a substantial burden of non-communicable diseases (NCDs), particularly type 2 diabetes (diabetes) and hypertension. However, these…”
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Gender differences in mortality and CD4 count response among virally suppressed HIV-positive patients
Published in Journal of women's health (Larchmont, N.Y. 2002) (01-02-2013)“…Treatment outcomes for antiretroviral therapy (ART) patients may vary by gender, but estimates from current evidence may be confounded by disease stage and…”
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Cohort profile: the South African National Health Laboratory Service (NHLS) National HIV Cohort
Published in BMJ open (19-10-2022)“…PurposeSouth Africa’s National Health Laboratory Service (NHLS) National HIV Cohort was established in 2015 to facilitate monitoring, evaluation and research…”
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Gaps in the type 2 diabetes care cascade: a national perspective using South Africa's National Health Laboratory Service (NHLS) database
Published in BMC health services research (21-12-2023)“…Research out of South Africa estimates the total unmet need for care for those with type 2 diabetes mellitus (diabetes) at 80%. We evaluated the care cascade…”
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Blood pressure increases are associated with weight gain and not antiretroviral regimen or kidney function: a secondary analysis from the ADVANCE trial in South Africa
Published in Journal of the International AIDS Society (01-07-2024)“…Introduction Recent evidence has raised questions about whether newer HIV treatment regimens, including dolutegravir (DTG) and tenofovir alafenamide (TAF), are…”
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The interplay between CD4 cell count, viral load suppression and duration of antiretroviral therapy on mortality in a resource‐limited setting
Published in Tropical medicine & international health (01-05-2013)“…Objective To examine the interaction between CD4 cell count, viral load suppression and duration of antiretroviral therapy (ART) on mortality. Methods Cohort…”
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Correction: Estimating retention in HIV care accounting for patient transfers: A national laboratory cohort study in South Africa
Published in PLoS medicine (01-08-2018)“…[This corrects the article DOI: 10.1371/journal.pmed.1002589.]…”
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Poor CD4 recovery and risk of subsequent progression to AIDS or death despite viral suppression in a South African cohort
Published in Journal of the International AIDS Society (01-01-2014)“…Introduction The prognostic role of CD4 response in the first six months of treatment in patients achieving early viral suppression during HIV treatment is…”
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Uptake of same-day initiation of HIV treatment in Malawi, South Africa, and Zambia as reported in routinely collected data: the SPRINT retrospective cohort study
Published in Gates open research (2023)“…Since 2017 global guidelines have recommended "same-day initiation" (SDI) of antiretroviral treatment (ART) for patients considered ready for treatment on the…”
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Health systems performance for hypertension control using a cascade of care approach in South Africa, 2011–2017
Published in PLOS global public health (07-09-2023)“…Hypertension is a major contributor to global morbidity and mortality. In South Africa, the government has employed a whole systems approach to address the…”
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The importance of clinic attendance in the first six months on antiretroviral treatment: a retrospective analysis at a large public sector HIV clinic in South Africa
Published in Journal of the International AIDS Society (07-12-2010)“…Background Adherence to care and treatment are essential for HIV‐infected individuals to benefit from antiretroviral therapy (ART). We sought to quantify the…”
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