Search Results - "BREM, Harold"

Clinical application of growth factors and cytokines in wound healing by Barrientos, Stephan, Brem, Harold, Stojadinovic, Olivera, Tomic-Canic, Marjana

“…Wound healing is a complex and dynamic biological process that involves the coordinated efforts of multiple cell types and is executed and regulated by…”
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The Role of Vascular Endothelial Growth Factor in Wound Healing by Bao, Philip, M.D, Kodra, Arber, B.A, Tomic-Canic, Marjana, Ph.D, Golinko, Michael S., M.D, Ehrlich, H. Paul, Ph.D, Brem, Harold, M.D

“…Background A chronic wound is tissue with an impaired ability to heal. This is often a consequence of one of the following etiologies: diabetes, venous reflux,…”
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Growth factors and cytokines in wound healing by Barrientos, Stephan, Stojadinovic, Olivera, Golinko, Michael S, Brem, Harold, Tomic-Canic, Marjana

“…Wound healing is an evolutionarily conserved, complex, multicellular process that, in skin, aims at barrier restoration. This process involves the coordinated…”
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High cost of stage IV pressure ulcers by Brem, Harold, M.D, Maggi, Jason, M.D, Nierman, David, M.D, Rolnitzky, Linda, M.S, Bell, David, B.S, Rennert, Robert, B.A, Golinko, Michael, M.D, Yan, Alan, M.D, Lyder, Courtney, N.D, Vladeck, Bruce, Ph.D

“…Abstract Background The aim of this study was to calculate and analyze the cost of treatment for stage IV pressure ulcers. Methods A retrospective chart…”
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Pharmacological and Genetic Inhibition of Caveolin-1 Promotes Epithelialization and Wound Closure by Jozic, Ivan, Sawaya, Andrew P., Pastar, Irena, Head, Cheyanne R., Wong, Lulu L., Glinos, George D., Wikramanayake, Tongyu Cao, Brem, Harold, Kirsner, Robert S., Tomic-Canic, Marjana

“…Chronic wounds—including diabetic foot ulcers, venous leg ulcers, and pressure ulcers—represent a major health problem that demands an urgent solution and new…”
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Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury by Vukelic, Sasa, Stojadinovic, Olivera, Pastar, Irena, Rabach, Morgan, Krzyzanowska, Agata, Lebrun, Elizabeth, Davis, Stephen C., Resnik, Sydney, Brem, Harold, Tomic-Canic, Marjana

“…Glucocorticoids (GCs) are known inhibitors of wound healing. In this study we report the novel finding that both keratinocytes in vitro and epidermis in vivo…”
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Induction of Specific MicroRNAs Inhibits Cutaneous Wound Healing by Pastar, Irena, Khan, Aly Azeem, Stojadinovic, Olivera, Lebrun, Elizabeth A., Medina, Mayrin Correa, Brem, Harold, Kirsner, Robert S., Jimenez, Joaquin J., Leslie, Christina, Tomic-Canic, Marjana

“…Chronic nonhealing wounds, such as venous ulcers (VUs), are a widespread and serious medical problem with high morbidity and mortality. The molecular pathology…”
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Chronic wound repair and healing in older adults: Current status and future research by Gould, Lisa, Abadir, Peter, Brem, Harold, Carter, Marissa, Conner-Kerr, Teresa, Davidson, Jeff, DiPietro, Luisa, Falanga, Vincent, Fife, Caroline, Gardner, Sue, Grice, Elizabeth, Harmon, John, Hazzard, William R., High, Kevin P., Houghton, Pamela, Jacobson, Nasreen, Kirsner, Robert S., Kovacs, Elizabeth J., Margolis, David, McFarland Horne, Frances, Reed, May J., Sullivan, Dennis H., Thom, Stephen, Tomic-Canic, Marjana, Walston, Jeremy, Whitney, JoAnne, Williams, John, Zieman, Susan, Schmader, Kenneth

“…The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this…”
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Evidence-based protocol for diabetic foot ulcers by Brem, Harold, Sheehan, Peter, Rosenberg, Harvey J, Schneider, Jillian S, Boulton, Andrew J M

“…Diabetic foot ulcers are the single biggest risk factor for nontraumatic foot amputations in persons with diabetes. Foot ulcers occur in 12 to 25 percent of…”
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Protocol for the successful treatment of venous ulcers by Brem, Harold, Kirsner, Robert S, Falanga, Vincent

“…Venous ulcers affect up to 2.5 million patients per year in the United States. Although not usually fatal, these chronic wounds severely affect patients'…”
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Protocol for the successful treatment of pressure ulcers by Brem, Harold, Lyder, Courtney

“…Bed-bound patients with pressure ulcers are almost twice as likely to die as are those without pressure ulcers. If pressure ulcers are treated with a…”
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Operative Debridement of Pressure Ulcers by Schiffman, Jessica, Golinko, Michael S., Yan, Alan, Flattau, Anna, Tomic-Canic, Marjana, Brem, Harold

“…Background Infection in severe pressure ulcers can lead to sepsis with a 6-month mortality as high as 68%. Methods Operative records of 142 consecutive…”
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Standardization of wound photography using the Wound Electronic Medical Record by Rennert, Robert, Golinko, Michael, Kaplan, Dave, Flattau, Anna, Brem, Harold

“…Rennert et al discuss why a standardized wound photography protocol is vital to the accuracy and objectivity of digital wound recording and how electronic…”
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Guidelines to aid healing of acute wounds by decreasing impediments of healing by Franz, Michael G., Robson, Martin C., Steed, David L., Barbul, Adrian, Brem, Harold, Cooper, Diane M., Leaper, David, Milner, Stephen M., Payne, Wyatt G., Wachtel, Thomas L., Wiersema-Bryant, Laurel

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A Perioperative Approach to Increase Limb Salvage When Treating Foot Ulcers in Patients With Diabetes by Howell, Raelina S., MD, Criscitelli, Theresa, EdD, RN, CNOR, Woods, Jon S., MD, Gillette, Brian M., PhD, Brem, Harold, MD, FACS, Gorenstein, Scott, MD, FACEP

“…ABSTRACT Foot ulceration in patients with diabetes increases the risk of lower extremity amputation. Major amputations produce substantial adverse…”
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Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice by Peppa, Melpomeni, Brem, Harold, Ehrlich, Paul, Zhang, Jian-Gang, Cai, Weijing, Li, Zhu, Croitoru, Anca, Thung, Swan, Vlassara, Helen

“…Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice Melpomeni Peppa 1 , Harold Brem 2 , Paul Ehrlich 3 , Jian-Gang Zhang 2 ,…”
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ADAM12: a potential target for the treatment of chronic wounds by Harsha, Asheesh, Stojadinovic, Olivera, Brem, Harold, Sehara-Fujisawa, Atsuko, Wewer, Ulla, Loomis, Cynthia A., Blobel, Carl P., Tomic-Canic, Marjana

“…Wound healing is a complex process involving multiple cellular events, including cell proliferation, migration, and tissue remodeling. A disintegrin and…”
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Cellular and molecular basis of wound healing in diabetes by Brem, Harold, Tomic-Canic, Marjana

“…Diabetic foot ulcers (DFUs), a leading cause of amputations, affect 15% of people with diabetes. A series of multiple mechanisms, including decreased cell and…”
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Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF by Brem, Harold, Golinko, Michael S, Stojadinovic, Olivera, Kodra, Arber, Diegelmann, Robert F, Vukelic, Sasa, Entero, Hyacinth, Coppock, Donald L, Tomic-Canic, Marjana

“…Multiple physiologic impairments are responsible for chronic wounds. A cell line grown which retains its phenotype from patient wounds would provide means of…”
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From an Enhanceosome to a Repressosome: Molecular Antagonism between Glucocorticoids and EGF Leads to Inhibition of Wound Healing by Lee, Brian, Vouthounis, Constantinos, Stojadinovic, Olivera, Brem, Harold, Im, Mark, Tomic-Canic, Marjana

“…Wound healing in its complexity depends on the concerted activity of many signaling pathways. Here, we analyzed how the simultaneous presence of…”
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