Search Results - "BREIT, S. N"

MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation by Fairlie, W. D., Moore, A. G., Bauskin, A. R., Russell, P. K., Zhang, H‐P., Breit, S. N.

“…As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor β (TGF‐β)…”
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Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity by Tsai, V W, Zhang, H P, Manandhar, R, Lee-Ng, K K M, Lebhar, H, Marquis, C P, Husaini, Y, Sainsbury, A, Brown, D A, Breit, S N

“…Objectives: To test the potential efficacy of recombinant macrophage inhibitory cytokine-1 (MIC-1/GDF15) as an obesity therapeutic. Methods: Male C57BL/6 J…”
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Functional characterization of the NCC27 nuclear protein in stable transfected CHO‐K1 cells by Tonini, R., Ferroni, A., Valenzuela, S. M., Warton, K., Campbell, T. J., Breit, S. N., Mazzanti, M.

“…ABSTRACT NCC27 belongs to a family of small, highly conserved, organellar ion channel proteins. It is constitutively expressed by native CHO‐K1 and dominantly…”
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Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15 by Tsai, V W W, Lin, S, Brown, D A, Salis, A, Breit, S N

“…Anorexia–cachexia associated with cancer and other diseases is a common and often fatal condition representing a large area of unmet medical need. It occurs…”
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Inhibition of the human ether‐a‐go‐go‐related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states by Walker, B D, Singleton, C B, Bursill, J A, Wyse, K R, Valenzuela, S M, Qiu, M R, Breit, S N, Campbell, T J

“…Cisapride is a prokinetic agent which has been associated with QT prolongation, torsades de pointes and cardiac arrest. The cellular mechanism for these…”
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The transforming growth factor-β superfamily cytokine macrophage inhibitory cytokine-1 is present in high concentrations in the serum of pregnant women by MOORE, A. G, BROWN, D. A, FAIRLIE, W. D, BAUSKIN, A. R, BROWN, P. K, MUNIER, M. L. C, RUSSELL, P. K, SALAMONSEN, L. A, WALLACE, E. M, BREIT, S. N

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Macrophage Inhibitory Cytokine-1 in Gestational Tissues and Maternal Serum in Normal and Pre-eclamptic Pregnancy by Marjono, A.B., Brown, D.A., Horton, K.E., Wallace, E.M., Breit, S.N., Manuelpillai, U.

“…Macrophage inhibitory cytokine-1 (MIC-1), a divergent member of transforming growth factor-β superfamily, has been recently shown to be produced by the human…”
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Structure of human CLIC3 at 2 Å resolution by Littler, D. R., Brown, L. J., Breit, S. N., Perrakis, A., Curmi, P. M. G.

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A potassium ion channel is involved in cytokine production by activated human macrophages by QIU, M. R., CAMPBELL, T. J., BREIT, S. N.

“…Summary Macrophages play an important role in immune and inflammatory responses, largely through secretion of bioactive molecule such as cytokines. While…”
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Inhibition of HERG potassium channels by the antimalarial agent halofantrine by Tie, H, Walker, B D, Singleton, C B, Valenzuela, S M, Bursill, J A, Wyse, K R, Breit, S N, Campbell, T J

“…Halofantrine is a widely used antimalarial agent which has been associated with prolongation of the ‘QT interval’ of the electrocardiogram (ECG), torsades de…”
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Antibody-based approach to high-volume genotyping for MIC-1 polymorphism by Brown, D A, Bauskin, A R, Fairlie, W D, Smith, M D, Liu, T, Xu, N, Breit, S N

“…Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the TGF-beta superfamily. There are at least two known alleles of MIC-1 that are due to a…”
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Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer by Mahon, K L, Lin, H-M, Castillo, L, Lee, B Y, Lee-Ng, M, Chatfield, M D, Chiam, K, Breit, S N, Brown, D A, Molloy, M P, Marx, G M, Pavlakis, N, Boyer, M J, Stockler, M R, Daly, R J, Henshall, S M, Horvath, L G

“…Background: Docetaxel improves symptoms and survival in metastatic castration-resistant prostate cancer (CRPC). However, ∼50% of patients are chemoresistant…”
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Radiation and the lung: a reevaluation of the mechanisms mediating pulmonary injury by Morgan, G W, Breit, S N

“…Recent data from several investigators, including our unit, have provided additional information on the etiology of radiation-induced lung damage. These data…”
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Inhibition of HERG channels stably expressed in a mammalian cell line by the antianginal agent perhexiline maleate by Walker, B D, Valenzuela, S M, Singleton, C B, Tie, H, Bursill, J A, Wyse, K R, Qiu, M R, Breit, S N, Campbell, T J

“…Perhexiline has been used as an anti‐anginal agent for over 25 years, and is known to cause QT prolongation and torsades de pointes. We hypothesized that the…”
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Macrophage inhibitory cytokine‐1/growth differentiation factor‐15 as a predictor of colonic neoplasia by Danta, M., Barber, D. A., Zhang, H. P., Lee‐Ng, M., Baumgart, S. W. L., Tsai, V. W. W., Husaini, Y., Saxena, M., Marquis, C. P., Errington, W., Kerr, S., Breit, S. N., Brown, D. A.

“…Summary Background Serum macrophage inhibitory cytokine‐1 (MIC‐1/GDF15) concentration has been associated with colonic adenomas and carcinoma. Aims To…”
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MIC-1/GDF15 in Barrett’s oesophagus and oesophageal adenocarcinoma by Fisher, O M, Levert-Mignon, A J, Lord, S J, Lee-Ng, K K M, Botelho, N K, Falkenback, D, Thomas, M L, Bobryshev, Y V, Whiteman, D C, Brown, D A, Breit, S N, Lord, R V

“…Background: Biomarkers are needed to improve current diagnosis and surveillance strategies for patients with Barrett’s oesophagus (BO) and oesophageal…”
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Analysis of dendritic cell populations using a revised histological staging of morphoea by Gilmour, T.K., Wilkinson, B., Breit, S.N., Kossard, S.

“…Background Recent studies have suggested that dermal dendritic cells (DDCs) may play a part in maintaining the structure of the dermis and in dermal immune…”
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Variables in the isolation and culture of human monocytes that are of particular relevance to studies of HIV by Bennett, S, Breit, S N

“…Mononuclear phagocytes play an important role in human immunodeficiency virus (HIV) infection. However, knowledge of the extent of macrophage involvement in…”
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The heart of psychotropic drug therapy by Tie, H, Walker, BD, Valenzuela, SM, Breit, SN, Campbell, TJ

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Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer by Skipworth, R J E, Deans, D A C, Tan, B H L, Sangster, K, Paterson-Brown, S, Brown, D A, Hunter, M, Breit, S N, Ross, J A, Fearon, K C H

“…Background: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse…”
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