Search Results - "BREHM, Jessica H"

Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors by Gavegnano, Christina, Brehm, Jessica H, Dupuy, Franck P, Talla, Aarthi, Ribeiro, Susan Pereira, Kulpa, Deanna A, Cameron, Cheryl, Santos, Stephanie, Hurwitz, Selwyn J, Marconi, Vincent C, Routy, Jean-Pierre, Sabbagh, Laurent, Schinazi, Raymond F, Sékaly, Rafick Pierre

“…Despite advances in the treatment of HIV infection with ART, elucidating strategies to overcome HIV persistence, including blockade of viral reservoir…”
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A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals by Procopio, Francesco Andrea, Fromentin, Rémi, Kulpa, Deanna A., Brehm, Jessica H., Bebin, Anne-Gaelle, Strain, Matthew C., Richman, Douglas D., O'Doherty, Una, Palmer, Sarah, Hecht, Frederick M., Hoh, Rebecca, Barnard, Richard J.O., Miller, Michael D., Hazuda, Daria J., Deeks, Steven G., Sékaly, Rafick-Pierre, Chomont, Nicolas

“…Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic strategies aimed at reducing the size of the long-lived viral…”
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Selection of Mutations in the Connection and RNase H Domains of Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Increase Resistance to 3′-Azido-3′-Dideoxythymidine by BREHM, Jessica H, KOONTZ, Dianna, METEER, Jeffrey D, PATHAK, Vinay, SLUIS-CREMER, Nicolas, MELLORS, John W

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4 + T Cells by Kulpa, Deanna A, Talla, Aarthi, Brehm, Jessica H, Ribeiro, Susan Pereira, Yuan, Sally, Bebin-Blackwell, Anne-Gaelle, Miller, Michael, Barnard, Richard, Deeks, Steven G, Hazuda, Daria, Chomont, Nicolas, Sékaly, Rafick-Pierre

“…During antiretroviral therapy (ART), human immunodeficiency virus type 1 (HIV-1) persists as a latent reservoir in CD4 T cell subsets in central memory (T ),…”
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Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase by Brehm, Jessica H, Scott, Yanille, Koontz, Dianna L, Perry, Steven, Hammer, Scott, Katzenstein, David, Mellors, John W, Sluis-Cremer, Nicolas

“…We previously demonstrated in vitro that zidovudine (AZT) selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H) domain of HIV-1…”
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Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo by Nixon, Christopher C., Mavigner, Maud, Sampey, Gavin C., Brooks, Alyssa D., Spagnuolo, Rae Ann, Irlbeck, David M., Mattingly, Cameron, Ho, Phong T., Schoof, Nils, Cammon, Corinne G., Tharp, Greg K., Kanke, Matthew, Wang, Zhang, Cleary, Rachel A., Upadhyay, Amit A., De, Chandrav, Wills, Saintedym R., Falcinelli, Shane D., Galardi, Cristin, Walum, Hasse, Schramm, Nathaniel J., Deutsch, Jennifer, Lifson, Jeffrey D., Fennessey, Christine M., Keele, Brandon F., Jean, Sherrie, Maguire, Sean, Liao, Baolin, Browne, Edward P., Ferris, Robert G., Brehm, Jessica H., Favre, David, Vanderford, Thomas H., Bosinger, Steven E., Jones, Corbin D., Routy, Jean-Pierre, Archin, Nancie M., Margolis, David M., Wahl, Angela, Dunham, Richard M., Silvestri, Guido, Chahroudi, Ann, Garcia, J. Victor

“…Long-lasting, latently infected resting CD4 + T cells are the greatest obstacle to obtaining a cure for HIV infection, as these cells can persist despite…”
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The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription by Okoye, Afam A, Fromentin, Rémi, Takata, Hiroshi, Brehm, Jessica H, Fukazawa, Yoshinori, Randall, Bryan, Pardons, Marion, Tai, Vincent, Tang, Jun, Smedley, Jeremy, Axthelm, Michael, Lifson, Jeffrey D, Picker, Louis J, Favre, David, Trautmann, Lydie, Chomont, Nicolas

“…Activation of the NF-κB signaling pathway by Protein Kinase C (PKC) agonists is a potent mechanism for human immunodeficiency virus (HIV) latency disruption in…”
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The immunological synapse: the gateway to the HIV reservoir by Kulpa, Deanna A., Brehm, Jessica H., Fromentin, Rémi, Cooper, Anthony, Cooper, Colleen, Ahlers, Jeffrey, Chomont, Nicolas, Sékaly, Rafick-Pierre

“…Summary A major challenge in the development of a cure for human immunodeficiency virus (HIV) has been the incomplete understanding of the basic mechanisms…”
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EXAFS Spectroscopic Evidence for an FeO Unit in the Fe(IV) Intermediate Observed during Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase by Riggs-Gelasco, Pamela J, Price, John C, Guyer, Robert B, Brehm, Jessica H, Barr, Eric W, Bollinger, J. Martin, Krebs, Carsten

“…The Fe(II)- and α-ketoglutarate-dependent dioxygenases catalyze hydroxylation reactions of considerable biomedical and environmental significance. Recently,…”
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Mechanism by which a Glutamine to Leucine Substitution at Residue 509 in the Ribonuclease H Domain of HIV-1 Reverse Transcriptase Confers Zidovudine Resistance by Brehm, Jessica H, Mellors, John W, Sluis-Cremer, Nicolas

“…We recently reported that zidovudine (AZT) selected for the Q509L mutation in the ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT), which…”
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Frequent Emergence of N348I in HIV-1 Subtype C Reverse Transcriptase with Failure of Initial Therapy Reduces Susceptibility to Reverse-Transcriptase Inhibitors by Brehm, Jessica H., Koontz, Dianna L., Wallis, Carole L., Shutt, Kathleen A., Sanne, Ian, Wood, Robin, McIntyre, James A., Stevens, Wendy S., Sluis-Cremer, Nicolas, Mellors, John W.

“…Background. It is not known how often mutations in the connection and ribonuclease H domains of reverse transcriptase (RT) emerge with failure of first-line…”
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Failure of Initial Therapy With Two Nucleosides and Efavirenz Is Not Associated With Early Emergence of Mutations in the C-Terminus of HIV-1 Reverse Transcriptase by Brehm, Jessica H, Lalama, Christina M, Hughes, Michael D, Haubrich, Richard, Riddler, Sharon A, Sluis-Cremer, Nicolas, Mellors, John W

“…It is uncertain how often mutations in the connection or RNase H domains of HIV-1 reverse transcriptase (RT) emerge with failure of first-line antiretroviral…”
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Zidovudine by Brehm, Jessica H, Scott, Yanille, Koontz, Dianna L, Perry, Steven, Hammer, Scott, Katzenstein, David, Mellors, John W, Sluis-Cremer, Nicolas

“…Background We previously demonstrated in vitro that zidovudine (AZT) selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H) domain of…”
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