Search Results - "BREAKEFIELD, XANDRA O."

RNA delivery by extracellular vesicles in mammalian cells and its applications by O’Brien, Killian, Breyne, Koen, Ughetto, Stefano, Laurent, Louise C., Breakefield, Xandra O.

“…The term ‘extracellular vesicles’ refers to a heterogeneous population of vesicular bodies of cellular origin that derive either from the endosomal compartment…”
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Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions by György, Bence, Hung, Michelle E, Breakefield, Xandra O, Leonard, Joshua N

“…This review provides an updated perspective on rapidly proliferating efforts to harness extracellular vesicles (EVs) for therapeutic applications. We summarize…”
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Coding and noncoding landscape of extracellular RNA released by human glioma stem cells by Wei, Zhiyun, Batagov, Arsen O., Schinelli, Sergio, Wang, Jintu, Wang, Yang, El Fatimy, Rachid, Rabinovsky, Rosalia, Balaj, Leonora, Chen, Clark C., Hochberg, Fred, Carter, Bob, Breakefield, Xandra O., Krichevsky, Anna M.

“…Tumor-released RNA may mediate intercellular communication and serve as biomarkers. Here we develop a protocol enabling quantitative, minimally biased analysis…”
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Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma by Shao, Huilin, Chung, Jaehoon, Lee, Kyungheon, Balaj, Leonora, Min, Changwook, Carter, Bob S., Hochberg, Fred H., Breakefield, Xandra O., Lee, Hakho, Weissleder, Ralph

“…Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a…”
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Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter by Lai, Charles P, Mardini, Osama, Ericsson, Maria, Prabhakar, Shilpa, Maguire, Casey A, Chen, John W, Tannous, Bakhos A, Breakefield, Xandra O

“…Extracellular vesicles (EVs) are nanosized vesicles released by normal and diseased cells as a novel form of intercellular communication and can serve as an…”
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Viral vectors for therapy of neurologic diseases by Choudhury, Sourav R., Hudry, Eloise, Maguire, Casey A., Sena-Esteves, Miguel, Breakefield, Xandra O., Grandi, Paola

“…Neurological disorders – disorders of the brain, spine and associated nerves – are a leading contributor to global disease burden with a shockingly large…”
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Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy by Shao, Huilin, Chung, Jaehoon, Balaj, Leonora, Charest, Alain, Bigner, Darell D, Carter, Bob S, Hochberg, Fred H, Breakefield, Xandra O, Weissleder, Ralph, Lee, Hakho

“…Cancer cells shed large numbers of small, membrane-bound microvesicles (MVs) into the circulation, which have diagnostic potential but have proved difficult to…”
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High levels of AAV vector integration into CRISPR-induced DNA breaks by Hanlon, Killian S., Kleinstiver, Benjamin P., Garcia, Sara P., Zaborowski, Mikołaj P., Volak, Adrienn, Spirig, Stefan E., Muller, Alissa, Sousa, Alexander A., Tsai, Shengdar Q., Bengtsson, Niclas E., Lööv, Camilla, Ingelsson, Martin, Chamberlain, Jeffrey S., Corey, David P., Aryee, Martin J., Joung, J. Keith, Breakefield, Xandra O., Maguire, Casey A., György, Bence

“…Adeno-associated virus (AAV) vectors have shown promising results in preclinical models, but the genomic consequences of transduction with AAV vectors encoding…”
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Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation by Srinivasan, Srimeenakshi, Yeri, Ashish, Cheah, Pike See, Chung, Allen, Danielson, Kirsty, De Hoff, Peter, Filant, Justyna, Laurent, Clara D., Laurent, Lucie D., Magee, Rogan, Moeller, Courtney, Murthy, Venkatesh L., Nejad, Parham, Paul, Anu, Rigoutsos, Isidore, Rodosthenous, Rodosthenis, Shah, Ravi V., Simonson, Bridget, To, Cuong, Wong, David, Yan, Irene K., Zhang, Xuan, Balaj, Leonora, Breakefield, Xandra O., Daaboul, George, Gandhi, Roopali, Lapidus, Jodi, Londin, Eric, Patel, Tushar, Raffai, Robert L., Sood, Anil K., Alexander, Roger P., Das, Saumya, Laurent, Louise C.

“…Poor reproducibility within and across studies arising from lack of knowledge regarding the performance of extracellular RNA (exRNA) isolation methods has…”
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MiR-21 in the extracellular vesicles (EVs) of cerebrospinal fluid (CSF): a platform for glioblastoma biomarker development by Akers, Johnny C, Ramakrishnan, Valya, Kim, Ryan, Skog, Johan, Nakano, Ichiro, Pingle, Sandeep, Kalinina, Juliya, Hua, Wei, Kesari, Santosh, Mao, Ying, Breakefield, Xandra O, Hochberg, Fred H, Van Meir, Erwin G, Carter, Bob S, Chen, Clark C

“…Glioblastoma cells secrete extra-cellular vesicles (EVs) containing microRNAs (miRNAs). Analysis of these EV miRNAs in the bio-fluids of afflicted patients…”
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SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions by Pucci, Ferdinando, Garris, Christopher, Lai, Charles P., Newton, Andita, Pfirschke, Christina, Engblom, Camilla, Alvarez, David, Sprachman, Melissa, Evavold, Charles, Magnuson, Angela, von Andrian, Ulrich H., Glatz, Katharina, Breakefield, Xandra O., Mempel, Thorsten R., Weissleder, Ralph, Pittet, Mikael J.

“…Tumor-derived extracellular vesicles (tEVs) are important signals in tumor–host cell communication, yet it remains unclear how endogenously produced tEVs…”
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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21 by Abels, Erik R., Maas, Sybren L.N., Nieland, Lisa, Wei, Zhiyun, Cheah, Pike See, Tai, Eric, Kolsteeg, Christy-Joy, Dusoswa, Sophie A., Ting, David T., Hickman, Suzanne, El Khoury, Joseph, Krichevsky, Anna M., Broekman, Marike L.D., Breakefield, Xandra O.

“…Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in the CNS and make up a substantial portion of the tumor mass…”
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Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth by Mizrak, Arda, Bolukbasi, Mehmet Fatih, Ozdener, Gokhan Baris, Brenner, Gary J, Madlener, Sibylle, Erkan, Erdogan Pekcan, Ströbel, Thomas, Breakefield, Xandra O, Saydam, Okay

“…Microvesicles (MVs) play an important role in intercellular communication by carrying mRNAs, microRNAs (miRNAs), non-coding RNAs, proteins, and DNA from cell…”
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Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV by György, Bence, Sage, Cyrille, Indzhykulian, Artur A., Scheffer, Deborah I., Brisson, Alain R., Tan, Sisareuth, Wu, Xudong, Volak, Adrienn, Mu, Dakai, Tamvakologos, Panos I., Li, Yaqiao, Fitzpatrick, Zachary, Ericsson, Maria, Breakefield, Xandra O., Corey, David P., Maguire, Casey A.

“…Adeno-associated virus (AAV) is a safe and effective vector for gene therapy for retinal disorders. Gene therapy for hearing disorders is not as advanced, in…”
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Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles by Reátegui, Eduardo, van der Vos, Kristan E., Lai, Charles P., Zeinali, Mahnaz, Atai, Nadia A., Aldikacti, Berent, Floyd, Frederick P., H. Khankhel, Aimal, Thapar, Vishal, Hochberg, Fred H., Sequist, Lecia V., Nahed, Brian V., S. Carter, Bob, Toner, Mehmet, Balaj, Leonora, T. Ting, David, Breakefield, Xandra O., Stott, Shannon L.

“…Extracellular vesicles (EVs) carry RNA, DNA, proteins, and lipids. Specifically, tumor-derived EVs have the potential to be utilized as disease-specific…”
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Heparin affinity purification of extracellular vesicles by Balaj, Leonora, Atai, Nadia A., Chen, Weilin, Mu, Dakai, Tannous, Bakhos A., Breakefield, Xandra O., Skog, Johan, Maguire, Casey A.

“…Extracellular vesicles (EVs) are lipid membrane vesicles released by cells. They carry active biomolecules including DNA, RNA and protein which can be…”
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Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells by Lucero, Rocco, Zappulli, Valentina, Sammarco, Alessandro, Murillo, Oscar D., Cheah, Pike See, Srinivasan, Srimeenakshi, Tai, Eric, Ting, David T., Wei, Zhiyun, Roth, Matthew E., Laurent, Louise C., Krichevsky, Anna M., Breakefield, Xandra O., Milosavljevic, Aleksandar

“…Glioblastoma (GBM) is characterized by aberrant vascularization and a complex tumor microenvironment. The failure of anti-angiogenic therapies suggests…”
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Emerging roles of extracellular vesicles in the nervous system by Rajendran, Lawrence, Bali, Jitin, Barr, Maureen M, Court, Felipe A, Krämer-Albers, Eva-Maria, Picou, Frederic, Raposo, Graça, van der Vos, Kristan E, van Niel, Guillaume, Wang, Juan, Breakefield, Xandra O

“…Information exchange executed by extracellular vesicles, including exosomes, is a newly described form of intercellular communication important in the…”
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Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain by van der Vos, Kristan E, Abels, Erik R, Zhang, Xuan, Lai, Charles, Carrizosa, Esteban, Oakley, Derek, Prabhakar, Shilpa, Mardini, Osama, Crommentuijn, Matheus H W, Skog, Johan, Krichevsky, Anna M, Stemmer-Rachamimov, Anat, Mempel, Thorsten R, El Khoury, Joseph, Hickman, Suzanne E, Breakefield, Xandra O

“…To understand the ability of gliomas to manipulate their microenvironment, we visualized the transfer of vesicles and the effects of tumor-released…”
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Dual Immunostimulatory Pathway Agonism through a Synthetic Nanocarrier Triggers Robust Anti‐Tumor Immunity in Murine Glioblastoma by Lugani, Sophie, Halabi, Elias A., Oh, Juhyun, Kohler, Rainer H., Peterson, Hannah M., Breakefield, Xandra O., Chiocca, E. Antonio A., Miller, Miles A., Garris, Christopher S., Weissleder, Ralph

“…Myeloid cells are abundant, create a highly immunosuppressive environment in glioblastoma (GBM), and thus contribute to poor immunotherapy responses. Based on…”
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