Search Results - "BRAYNE, C"

Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease by Hunter, S, Brayne, C

“…Many models of disease progression in Alzheimer’s disease (AD) have been proposed to help guide experimental design and aid the interpretation of results…”
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Mild cognitive impairment: a concept in evolution by Petersen, R. C., Caracciolo, B., Brayne, C., Gauthier, S., Jelic, V., Fratiglioni, L.

“…The construct of mild cognitive impairment (MCI) has evolved over the past 10 years since the publication of the new MCI definition at the Key Symposium in…”
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Evolution of cognitive dysfunction in an incident Parkinson's disease cohort by Williams-Gray, C. H., Foltynie, T., Brayne, C. E. G., Robbins, T. W., Barker, R. A.

“…We have previously performed detailed clinical and neuropsychological assessments in a community-based cohort of patients with newly diagnosed parkinsonism,…”
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A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II by Matthews, F. E., Stephan, B. C. M., Robinson, L., Jagger, C., Barnes, L. E., Arthur, A., Brayne, C.

“…Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over…”
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Inability to get up after falling, subsequent time on floor, and summoning help: prospective cohort study in people over 90 by Fleming, Jane, Brayne, Carol

“…Objectives To describe the incidence and extent of lying on the floor for a long time after being unable to get up from a fall among people aged over 90; to…”
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Healthy ageing, resilience and wellbeing by Cosco, T. D., Howse, K., Brayne, C.

“…The extension of life does not appear to be slowing, representing a great achievement for mankind as well as a challenge for ageing populations. As we move…”
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Using the GHQ-12 to screen for mental health problems among primary care patients: psychometrics and practical considerations by Anjara, S G, Bonetto, C, Van Bortel, T, Brayne, C

“…This study explores the factor structure of the Indonesian version of the GHQ-12 based on several theoretical perspectives and determines the threshold for…”
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Dementia in western Europe: epidemiological evidence and implications for policy making by Wu, Yu-Tzu, MSc, Fratiglioni, Laura, Prof, Matthews, Fiona E, Prof, Lobo, Antonio, Prof, Breteler, Monique M B, Prof, Skoog, Ingmar, Prof, Brayne, Carol, Prof

“…Summary Dementia is receiving increasing attention from governments and politicians. Epidemiological research based on western European populations done 20…”
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A systematic review of depression and mental illness preceding Parkinson's disease by Ishihara, L., Brayne, C.

“…Depression has been reported in several studies to be more common in Parkinson's disease (PD) patients than in the general population, and there may be overlap…”
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Intentional weight loss in overweight and obese individuals and cognitive function: a systematic review and meta‐analysis by Siervo, M, Arnold, R, Wells, J. C. K, Tagliabue, A, Colantuoni, A, Albanese, E, Brayne, C, Stephan, B. C. M

“…High adiposity in middle age is associated with higher dementia risk. The association between weight loss and cognitive function in older adults is still…”
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Patterns and stages of α-synucleinopathy : Relevance in a population-based cohort by ZACCAI, J, BRAYNE, C, MCKEITH, I, MATTHEWS, F, INCE, P. G

“…It is proposed that alpha-synucleinopathy (AS) initially affects the medulla oblongata and progresses to more rostral brain areas in a hierarchical sequence…”
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Daytime napping, sleep duration and increased 8-year risk of type 2 diabetes in a British population by Leng, Y, Cappuccio, F.P, Surtees, P.G, Luben, R, Brayne, C, Khaw, K.-T

“…Abstract Background and aims Few studies have prospectively examined the relationship between daytime napping and risk of type 2 diabetes. We aimed to study…”
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Incidence of early-onset dementias in Cambridgeshire, United Kingdom by MERCY, L, HODGES, J. R, DAWSON, K, BARKER, R. A, BRAYNE, C

“…To estimate the incidence of early-onset dementias in a defined area of Cambridgeshire served by Addenbrooke's Hospital. The area selected for the study was…”
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Dementia and survival in Parkinson disease : A 12-year population study by BUTER, T. C, VAN DEN HOUT, A, MATTHEWS, F. E, LARSEN, J. P, BRAYNE, C, AARSLAND, D

“…The risk for dementia in Parkinson disease (PD) is high, with important clinical consequences for patients with PD. However, the absolute risk of dementia and…”
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Microinfarcts in an older population‐representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease by Ince, P. G., Minett, T., Forster, G., Brayne, C., Wharton, S. B.

“…Introduction Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship…”
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Global prevalence of dementia: a Delphi consensus study by Ferri, Cleusa P, Prince, Martin, Brayne, Carol, Brodaty, Henry, Fratiglioni, Laura, Ganguli, Mary, Hall, Kathleen, Hasegawa, Kazuo, Hendrie, Hugh, Huang, Yueqin, Jorm, Anthony, Mathers, Colin, Menezes, Paulo R, Rimmer, Elizabeth, Scazufca, Marcia

“…100 years after the first description, Alzheimer's disease is one of the most disabling and burdensome health conditions worldwide. We used the Delphi…”
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The prevalence of frontotemporal dementia by RATNAVALLI, E, BRAYNE, C, DAWSON, K, HODGES, J. R

“…To estimate the prevalence of frontotemporal dementia (FTD) and other degenerative early-onset dementias in a geographically defined population. Early-onset…”
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The natural history of treated Parkinson's disease in an incident, community based cohort by Evans, Jonathan R, Mason, Sarah L, Williams-Gray, Caroline H, Foltynie, Thomas, Brayne, Carol, Robbins, Trevor W, Barker, Roger A

“…BackgroundOur understanding of the natural history of idiopathic Parkinson's disease (PD) remains limited. In the era of potential disease modifying therapies,…”
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Lifetime Prevalence and Factors Associated with Head Injury among Older People in Low and Middle Income Countries: A 10/66 Study by Khan, A, Prince, M, Brayne, C, Prina, A M

“…Traumatic brain injury (TBI) is a growing public health problem around the world, yet there is little information on the prevalence of head injury in low and…”
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Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain by Simpson, J.E, Ince, P.G, Lace, G, Forster, G, Shaw, P.J, Matthews, F, Savva, G, Brayne, C, Wharton, S.B

“…Abstract Astrocyte pathology occurs in association with Alzheimer's disease (AD) and in brain ageing, but is poorly characterised. We sought to define the…”
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