Search Results - "BRAY, Jeffrey D"

U.S. Food and Drug Administration Approval: Carfilzomib for the Treatment of Multiple Myeloma by HERNDON, Thomas M, DEISSEROTH, Albert, PALMBY, Todd R, JEE, Josephine, ADAMS, William, MAHAYNI, Houda, BROWN, Janice, DORANTES, Angelica, SRIDHARA, Rajeshwari, FARRELL, Ann T, PAZDUR, Richard, KAMINSKAS, Edvardas, KANE, Robert C, KOTI, Kallappa M, ROTHMANN, Mark D, HABTEMARIAM, Bahru, BULLOCK, Julie, BRAY, Jeffrey D, HAWES, Jessica

“…The U.S. Food and Drug Administration (FDA) review leading to accelerated approval of carfilzomib is described. A single-arm trial enrolled 266 patients with…”
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Development of a Small-Molecule Serum-and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic by SHERK, Andrea B, FRIGO, Daniel E, NORRIS, John D, MCDONNELL, Donald P, SCHNACKENBERG, Christine G, BRAY, Jeffrey D, LAPING, Nicholas J, TRIZNA, Walter, HAMMOND, Marlys, PATTERSON, Jaclyn R, THOMPSON, Scott K, KAZMIN, Dmitri

“…Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth…”
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Activated glucocorticoid and eicosanoid pathways in endometriosis by Monsivais, Diana, M.S, Bray, Jeffrey D., Ph.D, Su, Emily, M.D, Pavone, Mary Ellen, M.D, Dyson, Matthew T., Ph.D, Navarro, Antonia, B.S, Kakinuma, Toshiyuki, M.D., Ph.D, Bulun, Serdar E., M.D

“…Objective To define altered gene expression networks in endometriosis. Design Experiments using endometriotic tissues and primary cells. Setting Division of…”
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A Structural and in Vitro Characterization of Asoprisnil: A Selective Progesterone Receptor Modulator by Madauss, Kevin P, Grygielko, Eugene T, Deng, Su-Jun, Sulpizio, Anthony C, Stanley, Thomas B, Wu, Charlene, Short, Steve A, Thompson, Scott K, Stewart, Eugene L, Laping, Nicholas J, Williams, Shawn P, Bray, Jeffrey D

“…Selective progesterone receptor modulators (SPRMs) have been suggested as therapeutic agents for treatment of gynecological disorders. One such SPRM,…”
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Noninvasive assessment of ectopic uterine tissue development in rats using magnetic resonance imaging by Lenhard, Stephen C., M.S, Haimbach, Robin E., B.S, Sulpizio, Anthony C., B.S, Brooks, David P., Ph.D, Bray, Jeffrey D., Ph.D, Jucker, Beat M., Ph.D

“…Objective To non-invasively characterize ectopic uterine tissue (EUT) development in a modified autologous rat surgical model of endometriosis using magnetic…”
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EADB: an estrogenic activity database for assessing potential endocrine activity by Shen, Jie, Xu, Lei, Fang, Hong, Richard, Ann M, Bray, Jeffrey D, Judson, Richard S, Zhou, Guangxu, Colatsky, Thomas J, Aungst, Jason L, Teng, Christina, Harris, Steve C, Ge, Weigong, Dai, Susie Y, Su, Zhenqiang, Jacobs, Abigail C, Harrouk, Wafa, Perkins, Roger, Tong, Weida, Hong, Huixiao

“…Endocrine-active chemicals can potentially have adverse effects on both humans and wildlife. They can interfere with the body's endocrine system through direct…”
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Estrogen-induced stromal cell-derived factor-1 (SDF-1/ Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor α in rat uterine cells and tissues by Glace, Lindsay, Grygielko, Eugene T., Boyle, Ryan, Wang, Qi, Laping, Nicholas J., Sulpizio, Anthony C., Bray, Jeffrey D.

“…Endometriosis, defined as the presence of endometrial glands and stroma at extra-uterine sites, is a gynecological condition that affects women of reproductive…”
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Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists by Thompson, Scott K., Washburn, David G., Frazee, James S., Madauss, Kevin P., Hoang, Tram H., Lapinski, Leahann, Grygielko, Eugene T., Glace, Lindsay E., Trizna, Walter, Williams, Shawn P., Duraiswami, Chaya, Bray, Jeffrey D., Laping, Nicholas J.

“…Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial…”
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2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]thieno[2,3- b]pyridine derivatives as selective progesterone receptor agonists by Wang, Yonghui, Duraiswami, Chaya, Madauss, Kevin P., Tran, Thuy B., Williams, Shawn P., Deng, Su-Jun, Graybill, Todd L., Hammond, Marlys, Jones, David G., Grygielko, Eugene T., Bray, Jeffrey D., Thompson, Scott K.

“…A novel series of 2-amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2′,3′:4,5]thieno[2,3- b]pyridine derivatives was identified as selective PR…”
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Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells by Bray, Jeffrey D., Jelinsky, Scott, Ghatge, Radhika, Bray, Jenifer A., Tunkey, Christopher, Saraf, Kathryn, Jacobsen, Britta M., Richer, Jennifer K., Brown, Eugene L., Winneker, Richard C., Horwitz, Kathryn B., Lyttle, C. Richard

“…Progesterone (P4) is an essential reproductive steroid hormone required for many aspects of female reproductive physiology. Progestins are compounds that…”
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Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists by Hammond, Marlys, Patterson, Jaclyn R., Manns, Sharada, Hoang, Tram H., Washburn, David G., Trizna, Walter, Glace, Lindsay, Grygielko, Eugene T., Nagilla, Rakesh, Nord, Melanie, Fries, Harvey E., Minick, Douglas J., Laping, Nicholas J., Bray, Jeffrey D., Thompson, Scott K.

“…Two series of amino acid-derived heterocyclic progesterone receptor (PR) ligands are reported. Tetrazole-containing ligands behaved as potent PR partial…”
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Improving the developability profile of pyrrolidine progesterone receptor partial agonists by Kallander, Lara S., Washburn, David G., Hoang, Tram H., Frazee, James S., Stoy, Patrick, Johnson, Latisha, Lu, Qing, Hammond, Marlys, Barton, Linda S., Patterson, Jaclyn R., Azzarano, Leonard M., Nagilla, Rakesh, Madauss, Kevin P., Williams, Shawn P., Stewart, Eugene L., Duraiswami, Chaya, Grygielko, Eugene T., Xu, Xiaoping, Laping, Nicholas J., Bray, Jeffrey D., Thompson, Scott K.

“…The previously reported pyrrolidine class of progesterone receptor partial agonists demonstrated excellent potency but suffered from serious liabilities…”
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Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists by Washburn, David G., Hoang, Tram H., Frazee, James S., Johnson, Latisha, Hammond, Marlys, Manns, Sharada, Madauss, Kevin P., Williams, Shawn P., Duraiswami, Chaya, Tran, Thuy B., Stewart, Eugene L., Grygielko, Eugene T., Glace, Lindsay E., Trizna, Walter, Nagilla, Rakesh, Bray, Jeffrey D., Thompson, Scott K.

“…We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR…”
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Trax (Translin-associated Factor X), a Primarily Cytoplasmic Protein, Inhibits the Binding of TB-RBP (Translin) to RNA by Chennathukuzhi, V M, Kurihara, Y, Bray, J D, Hecht, N B

“…Trax (Translin-associated factor X) has been shown to interact with TB-RBP/Translin by its coimmunoprecipitation and in yeast two-hybrid assays. Here we…”
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Identification and Characterization of cDNAs Encoding Four Novel Proteins that Interact with Translin Associated Factor-X by Bray, Jeffrey D., Chennathukuzhi, Vargheese M., Hecht, Norman B.

“…Translin-associated factor X (TRAX) is the predominantly cytoplasmic binding partner of TB-RBP/translin in mouse testis. Four mouse testis cDNAs encoding…”
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KIF2Aβ: A kinesin family member enriched in mouse male germ cells, interacts with translin associated factor-X (TRAX) by Bray, Jeffrey D., Chennathukuzhi, Vargheese M., Hecht, Norman B.

“…Translin associated factor X (TRAX) is a binding partner of TB‐RBP/Translin. A cDNA encoding the 260 C‐terminal amino acids of KIF2Aβ was isolated from mouse…”
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Altering the GTP binding site of the DNA/RNA-binding protein, Translin/TB-RBP, decreases RNA binding and may create a dominant negative phenotype by Chennathukuzhi, V M, Kurihara, Y, Bray, J D, Yang, J, Hecht, N B

“…The DNA/RNA-binding protein, Translin/Testis Brain RNA-binding protein (Translin/TB-RBP), contains a putative GTP binding site in its C-terminus which is…”
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Regulation of gene expression by PRA-910, a novel progesterone receptor modulator, in T47D cells by Bray, Jeffrey D, Zhang, Zhiming, Winneker, Richard C, Lyttle, C.Richard

“…Progestins play an important role in women’s health and are used in oral contraception, hormone therapy, and treatment of reproductive disorders. The effects…”
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Noninvasive assessment of ectopic uterine tissue development in rats using magnetic resonance imaging: Reproductive biology by LENHARD, Stephen C, HAIMBACH, Robin E, SULPIZIO, Anthony C, BROOKS, David P, BRAY, Jeffrey D, JUCKER, Beat M

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KIF2Abeta: A kinesin family member enriched in mouse male germ cells, interacts with translin associated factor-X (TRAX) by Bray, Jeffrey D, Chennathukuzhi, Vargheese M, Hecht, Norman B

“…Translin associated factor X (TRAX) is a binding partner of TB-RBP/Translin. A cDNA encoding the 260 C-terminal amino acids of KIF2Abeta was isolated from…”
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