Search Results - "BRAUN, Matthew"

Effective optical properties of non-absorbing nanoporous thin films by Braun, Matthew M., Pilon, Laurent

“…Numerous effective medium models have been proposed for the effective optical properties of nanoporous media. However, validations of these models against…”
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A Pilot Study on Professional Documentation: Do We Write From a Strengths Perspective? by Braun, Matthew J, Dunn, Winnie, Tomchek, Scott D

“…There is growing evidence supporting the use of strengths-based practices when serving families. The purpose of this study was to examine the use of…”
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The Target of Ezetimibe Is Niemann-Pick C1-Like 1 (NPC1L1) by Garcia-Calvo, Margarita, Lisnock, JeanMarie, Bull, Herbert G., Hawes, Brian E., Burnett, Duane A., Braun, Matthew P., Crona, James H., Davis, Harry R., Dean, Dennis C., Detmers, Patricia A., Graziano, Michael P., Hughes, Meredith, MacIntyre, D. Euan, Ogawa, Anthony, O'Neill, Kim A., Sai Prasad N. Iyer, Shevell, Diane E., Smith, Marsha M., Tang, Yui S., Makarewicz, Amanda M., Ujjainwalla, Feroze, Altmann, Scott W., Chapman, Kevin T., Thornberry, Nancy A., Goldstein, Joseph L.

“…Ezetimibe is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia, but its molecular target has been…”
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Evaluating interactive videoconferencing for assessing symptoms of autism by Reese, R Matthew, Jamison, Rene, Wendland, Maura, Fleming, Kandace, Braun, Matthew J, Schuttler, Jessica Oeth, Turek, Josh

“…Autism affects as many as 1 in 88 children. Best practices recommend early identification and intervention for optimal outcomes. Currently, a gap exists…”
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Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein by Chu, Xiao-Yan, Bleasby, Kelly, Yabut, Jocelyn, Cai, Xiaoxin, Chan, Grace Hoyee, Hafey, Michael J, Xu, Shiyao, Bergman, Arthur J, Braun, Matthew P, Dean, Dennis C, Evers, Raymond

“…Sitagliptin, a selective dipeptidyl peptidase 4 inhibitor recently approved for the treatment of type 2 diabetes, is excreted into the urine via active tubular…”
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Preliminary Evidence for the Integrated Systems Using Telemedicine by Reese, R Matthew, Braun, Matthew J, Hoffmeier, Sarah, Stickle, Lee, Rinner, Louann, Smith, Catherine, Ellerbeck, Kathryn, Jamison, Rene, Wendland, Maura, Jarrett, Lindsey, Hadorn, Megan

“…Autism affects as many as 1 in 68 children in the United States. Early identification and access to intervention services promote improved outcomes for…”
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Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide by Kumar, Sanjeev, Samuel, Koppara, Subramanian, Ramaswamy, Braun, Matthew P, Stearns, Ralph A, Chiu, Shuet-Hing Lee, Evans, David C, Baillie, Thomas A

“…Diclofenac is eliminated predominantly (approximately 50%) as its 4'-hydroxylated metabolite in humans, whereas the acyl glucuronide (AG) pathway appears more…”
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Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3 by Chu, Xiao-Yan, Huskey, Su-E W, Braun, Matthew P, Sarkadi, Balazs, Evans, David C, Evers, Raymond

“…Ethinylestradiol (EE) is one of the key constituents of oral contraceptives. Major metabolites of EE in humans are the glucuronide and sulfate conjugates,…”
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In Vitro Metabolic Activation of Lumiracoxib in Rat and Human Liver Preparations by Li, Ying, Slatter, J Greg, Zhang, Zhoupeng, Li, Yan, Doss, George A, Braun, Matthew P, Stearns, Ralph A, Dean, Dennis C, Baillie, Thomas A, Tang, Wei

“…Recent clinical reports have suggested that the cyclooxygenase-2 inhibitor, lumiracoxib (Prexige), may cause a rare but serious hepatotoxicity in patients. In…”
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Pharmacokinetics, Metabolism, and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Rats and Rhesus Monkeys by TAN, Eugene Y, HARTMANN, Georgy, WEI TANG, KUMAR, Sanjeev, QING CHEN, PEREIRA, Antonio, BRADLEY, Scott, DOSS, George, ZHANG, Andy Shiqiang, HO, Jonathan Z, BRAUN, Matthew P, DEAN, Dennis C

“…The pharmacokinetics and metabolism of anacetrapib (MK-0859), a novel cholesteryl ester transfer protein inhibitor, were examined in rats and rhesus monkeys…”
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Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans by KUMAR, Sanjeev, TAN, Eugene Y, KARANAM, Bindhu, DEAN, Dennis C, GENDRANO, Isaias Noel, GRAVES, Mark W, WAGNER, John A, KRISHNA, Rajesh, HARTMANN, Georgy, BIDDLE, Zachary, BERGMAN, Arthur J, DRU, James, HO, Jonathan Z, JONES, Allen N, STASKIEWICZ, Steve J, BRAUN, Matthew P

“…Anacetrapib is a novel cholesteryl ester transfer protein inhibitor being developed for the treatment of primary hypercholesterolemia and mixed dyslipidemia…”
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Double-blind crossover study to assess potential differences in cytochrome P450 3A4 activity in healthy subjects receiving ondansetron plus dexamethasone, with and without aprepitant by Stoch, S. Aubrey, Gargano, Cynthia, Valentine, Jack, Braun, Matthew P., Murphy, M. Gail, Fedgchin, Margaret, Majumdar, Anup, Pequignot, Edward, Gottesdiener, Keith M., Petty, Kevin J., Panebianco, Deborah, Dean, Dennis, Kraft, Walter K., Greenberg, Howard E.

“…Purpose Because glucocorticoids and the neurokinin-1 receptor antagonist aprepitant influence CYP3A4 activity, this study assessed whether aprepitant added to…”
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EVIDENCE FOR THE BIOACTIVATION OF ZOMEPIRAC AND TOLMETIN BY AN OXIDATIVE PATHWAY: IDENTIFICATION OF GLUTATHIONE ADDUCTS IN VITRO IN HUMAN LIVER MICROSOMES AND IN VIVO IN RATS by Chen, Qing, Doss, George A, Tung, Elaine C, Liu, Wensheng, Tang, Yui S, Braun, Matthew P, Didolkar, Varsha, Strauss, John R, Wang, Regina W, Stearns, Ralph A, Evans, David C, Baillie, Thomas A, Tang, Wei

“…Although zomepirac (ZP) and tolmetin (TM) induce anaphylactic reactions and form reactive acyl glucuronides, a direct link between the two events remains…”
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Metabolism and Renal Elimination of Gaboxadol in Humans: Role of UDP-Glucuronosyltransferases and Transporters by Chu, Xiao-Yan, Liang, Yuexia, Cai, Xiaoxin, Cuevas-Licea, Karla, Rippley, Ronda K, Kassahun, Kelem, Shou, Magang, Braun, Matthew P, Doss, George A, Anari, M. Reza, Evers, Raymond

“…Gaboxadol, a selective extrasynaptic agonist of the delta-containing γ-aminobutyric acid type A (GABAA) receptor, is excreted in humans into the urine as…”
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An efficient synthesis of carbon-14-labeled 6-[2-(dimethylamino)ethyl]-14-(1-ethylpropyl)-5,6,7,8-tetrahydroindolo [2,1-α] [2,5]benzodiazocine-11-carboxylic acid using Curtius rearrangement reaction as a key step by Zhang, Andy Shiqiang, Ho, Jonathan Z., Braun, Matthew P.

“…Here we report an efficient synthesis of 14C‐labeled…”
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Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake by Weinglass, Adam B, Köhler, Martin G, Nketiah, Emmanuel O, Liu, Jessica, Schmalhofer, William, Thomas, Anu, Williams, Brande, Beers, Lindsey, Smith, Lauren, Hafey, Mike, Bleasby, Kelly, Leone, Joseph, Tang, Yui Sing, Braun, Matthew, Ujjainwalla, Feroze, McCann, Margaret E, Kaczorowski, Gregory J, Garcia, Maria L

“…Absorption of dietary cholesterol in the proximal region of the intestine is mediated by Niemann-Pick C1-like protein (NPC1L1) and is sensitive to the…”
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Synthesis of a tritium-labeled photo-affinity probe based on an atypical leukotriene biosynthesis inhibitor by Kumar, Nag S., Braun, Matthew P., Chaudhary, Ashok G., Young, Robert N.

“…A radiolabeled photo‐affinity probe containing a diazirine group was designed and synthesized based on an atypical leukotriene (LT) biosynthesis inhibitor to…”
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Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand by Simeone, Joseph P., Braun, Matthew P., Leone, Joseph F., Lin, Peter, DeVita, Robert J., Garcia-Calvo, Margarita, Bull, Herb G., Lisnock, JeanMarie, Dean, Dennis C.

“…The discovery of a sulfur-35 labeled radioligand with high affinity for the NPC1L1 receptor across species is reported. During our effort to design a receptor…”
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Palladium-catalyzed hydroxycarbonylation as the key step in the synthesis of a carbon-14 labeled Maxi-K channel blocker by Simeone, Joseph P., Braun, Matthew P., Liu, Luping, Natarajan, Swaminathan R.

“…Carbon‐14 labeled sodium formate was utilized for the preparation of a radiolabeled tracer to support the development of a Maxi‐K channel blocker. Key to the…”
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Efficient Synthesis of 14C-Labeled 1H-Pyrazolo[3,4-d]pyrimidine and Related [4.3.0]-Bicyclic Pyrimidino Systems by Ho, Jonathan Z., Van Arsdale, Kyle R., Braun, Matthew P.

“…In support of a research program aimed at discovering purine‐related anticancer drug candidates, a method for the 14C‐labeling of pyrazolopyrimidines utilizing…”
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