Search Results - "BRATTAIN, M. G"

Dual inhibitors of PI3K/mTOR or mTOR-selective inhibitors: which way shall we go? by Sabbah, D A, Brattain, M G, Zhong, H

“…The phosphatidylinositol-3-kinase (PI3K)/AKT/mTOR signaling pathway is a central regulator in cell proliferation, growth, and angiogenesis. Inhibition of this…”
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Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis by Agarwal, E, Robb, C M, Smith, L M, Brattain, M G, Wang, J, Black, J D, Chowdhury, S

“…Survival signaling is critical for the metastatic program of cancer cells. The current study investigated the role of Akt survival proteins in colorectal…”
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Mutational inactivation of transforming growth factor β receptor type II in microsatellite stable colon cancers by GRADY, W. M, MYEROFF, L. L, KINZLER, K. W, VOGELSTEIN, B, WILLSON, J. K. V, MARKOWITZ, S, SWINLER, S. E, RAJPUT, A, THIAGALINGAM, S, LUTTERBAUGH, J. D, NEUMANN, A, BRATTAIN, M. G, JAY CHANG, KIM, S.-J

“…We previously demonstrated that mutational inactivation of transforming growth factor beta type II receptors (RIIs) is very common among the 13% of human colon…”
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Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells by Sun, L, Wu, G, Willson, J K, Zborowska, E, Yang, J, Rajkarunanayake, I, Wang, J, Gentry, L E, Wang, X F, Brattain, M G

“…The role of transforming growth factor (TGF) beta type II receptor in reversing the malignant phenotype of human breast cancer MCF-7 cells was examined. MCF-7…”
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Reversion of transcriptional repression of Sp1 by 5 aza-2' deoxycytidine restores TGF-β type II receptor expression in the pancreatic cancer cell line MIA PaCa-2 by VENKATASUBBARAO, Kolaparthi, AMMANAMANCHI, Sudhakar, BRATTAIN, Michael G, MIMARI, Damon, FREEMAN, Lames W

“…The pancreatic cancer cell line, MIA PaCa-2 is not responsive to transforming growth factor beta (TGF-beta) because of a lack of expression of the TGF-beta…”
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Induction of transforming growth factor-beta receptor type II expression in estrogen receptor-positive breast cancer cells through SP1 activation by 5-aza-2'-deoxycytidine by Ammanamanchi, S, Kim, S J, Sun, L Z, Brattain, M G

“…Previous studies suggest that estrogen receptor-positive (ER+) breast cancer cells acquire resistance to transforming growth factor-beta (TGF-beta) because of…”
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Contextual effects of transforming growth factor β on the tumorigenicity of human colon carcinoma cells by YE, S.-C, FOSTER, J. M, WENHUI LI, JIURONG LIANG, ZBOROWSKA, E, VENKATESWARLU, S, JIANGEN GONG, BRATTAIN, M. G, WILLSON, J. K. V

“…Transforming growth factor betas (TGF-betas) are a growth factor family with negative autocrine growth functions for most epithelial cells including colon…”
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Autocrine transforming growth factor-alpha is associated with progression of transformed properties in human colon cancer cells by ZIOBER, B. L, WILLSON, J. K. V, HYMPHREY, L. E, CHILDRESS-FIELDS, K, BRATTAIN, M. G

“…The GEO colon carcinoma cell line is weakly tumorigenic in athymic mice and shows differentiated properties both in tissue culture and in xenografts…”
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Defective cleavage of membrane bound TGFα leads to enhanced activation of the EGF receptor in malignant cells by HAISU YANG, DIANHUA JIANG, WENHUI LI, JIURONG LIANG, GENTRY, L. E, BRATTAIN, M. G

“…Transforming growth factor α (TGFα) is widely expressed in malignant as well as normal cells and is involved in regulating cell growth and differentiation…”
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Acetylated Sp3 Is a Transcriptional Activator by Ammanamanchi, Sudhakar, Freeman, James W., Brattain, Michael G.

“…Sp3 transcription factor can either activate or repress target gene expression. However, the molecular event that controls this dual function is unclear. We…”
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Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patient by GROSS, M. E, ZORBAS, M. A, DANELS, Y. J, GARCIA, R, GALLICK, G. E, OLIVE, M, BRATTAIN, M. G, BOMAN, B. M, YEOMAN, L. C

“…The receptor binding and cellular growth responses to exogenous epidermal growth factor (EGF) were studied using the DiFi cell line established from a familial…”
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Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines by LONG, B. H, WANG, L, LORICO, A, WANG, R. C. C, BRATTAIN, M. G, CASAZZA, A. M

“…Stable acquired resistance to etoposide (VP-16) or teniposide (VM-26) in HCT116 human colon carcinoma cells and A549 human lung adenocarcinoma cells, was…”
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Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide by Hoosein, N M, Kiener, P A, Curry, R C, Brattain, M G

“…The peptide gastrin has been shown to have growth stimulatory effects on normal as well as malignant gastrointestinal tissue. In this study, we have examined…”
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Antiproliferative effects of gastrin receptor antagonists and antibodies to gastrin on human colon carcinoma cell lines by HOOSEIN, N. M, KIENER, P. A, CURRY, R. C, ROVATI, L. C, MCGILBRA, D. K, BRATTAIN, M. G

“…The gastrointestinal hormone gastrin has been shown to stimulate the growth of normal colonic mucosa. To examine for a possible role of gastrin in the…”
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Growth stimulatory effect of pancreatic spasmolytic polypeptide on cultured colon and breast tumor cells by Hoosein, Naseema M., Thim, Lars, Jørgensen, Klavs H., Brattain, Michael G.

“…The effects of a novel polypeptide, pancreatic spasmolytic polypeptide (PSP) on a colon carcinoma cell line (HCT 116) were examined. PSP stimulated the…”
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Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells by Gong, JianGen, Ammanamanchi, Sudhakar, Ko, Tien C, Brattain, Michael G

“…We examined transforming growth factor-beta 1 (TGF-beta 1) effects on cell cycle progression of human colon carcinoma FET cells. TGF-beta 1 inhibited DNA…”
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The EGF/TGFα response element within the TGFα promoter consists of a multi-complex regulatory element by AWWAD, R, HUMPHREY, L. E, PERIYASAMY, B, SCOVELL, W. JR, WENHUI LI, COLEMAN, K, LYNCH, M, CARBONI, J, BRATTAIN, M. G, HOWELL, G. M

“…Autocrine TGFα is an important growth effector in the transformed phenotype. Growth stimulation of some colon cancer cells as well as other types of cancer…”
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Induction of carcinoembryonic antigen secretion and modulation of protein secretion/expression and fibronectin/laminin expression in human colon carcinoma cells by transforming growth factor-β by CHAKRABARTY, S, TOBON, A, VARANI, J, BRATTAIN, M. G

“…We have recently reported that TGF-beta induces a response similar to that of planar polar differentiation promoters in human colon carcinoma MOSER cells…”
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Sp3 Is a Transcriptional Repressor of Transforming Growth Factor-β Receptors by Ammanamanchi, Sudhakar, Brattain, Michael G.

“…MCF-7E breast cancer cells express transforming growth factor-β (TGF-β) receptors RI and RII in comparison to MCF-7L cells. We present data showing that Sp3…”
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Modulation of cell cycle control by vitamin D3 and its analogue, EB1089, in human breast cancer cells by WU, G, FAN, R. S, LI, W, KO, T. C, BRATTAIN, M. G

“…Examination of a panel of ER positive breast cancer cell lines showed that they were differentially growth inhibited by vitamin D3 and its analogue EB1089…”
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